TRIPODI MARCO

Professore Ordinario 
Settore scientifico disciplinare di riferimento  (BIO/13)
Ateneo Università degli Studi di ROMA "La Sapienza" 
Struttura di afferenza Dipartimento di MEDICINA MOLECOLARE 
Recapiti Elenco recapiti telefonici

Orari di ricevimento

on demand, previa appuntamento telefonico o mail.

Curriculum

Curriculum vitae
PERSONAL INFORMATION
WORK EXPERIENCE 2000–Present
Marco Tripodi
Dept. of Molecular Medicine, Sapienza University of Rome; 324, Viale Regina Elena, 00161 Rome (Italy)
+39 06 49918244
marco.tripodi@uniroma1.it
Sex Male | Date of birth 19/08/1955 | Nationality Italian
University Full Professor (SSD BIO/13)
“Sapienza” University of Rome, Italy; Dept. of Molecular Medicine, Rome (Italy) RESEARCH main efforts are directed toward:
· The characterization of the hepatic stem cell self renewal and differentiation
· The study of the epithelial-to-mesenchymal transition (EMT) in thehepatocyte
· The study hepatic cell-to-cell instructivesignaling
TEACHING:
· From 2000: “Biology and Genetic” at “Medicine and Surgery”Faculty
· From 2005: “Molecular Bases of Cellular processes”,at “Medical Biotechnologies”Faculty.
· 2006-2012: Coordinator at “Scienze Pasteuriane” DoctoralCourse
· 2012-2015: Coordinator at “Life Science ” Doctoral Course
· 2017-current : Coordinator at “Life Science ” Doctoral Course
· 2014/2020 Sapienza School for Advanced Studies (SSAS) Senior fellow
ORGANIZATIONAL COMPETENCE:
· From 2007-up to date: Member of the Scientific Committee of “Pasteur - Cenci Bolognetti” Institute.
· 2015-2018 Head of Department - Dept. of Cellular Biotechnology and Haematology , “Sapienza” University ofRome
· 2018/2020 Sapienza School for Advanced Studies (SSAS) Life Science Class coordinator
· 2000-Present: Responsible for “U.O.”, “Gene Expression and Experimental Hepatology” (“Espressione del Gene ed Epatologia Sperimentale”), “Istituto Nazionale Malattie Infettive Lazzaro Spallanzani” IRCCS, Rome.
EMBL – Postdoctoral Fellow for 24 months
European Molecular Biology Laboratory of Heidelberg, Heidelberg (Germany)
CEE Fellow European Molecular Biology Laboratory of Heidelberg
for 15 months
European Molecular Biology Laboratory of Heidelberg, Heidelberg (Germany)
Master Degree in Biological Sciences with Honour
“Sapienza” University of Rome, Italy, Rome (Italy)
EDUCATION AND TRAINING 1986–1987
1982–1983
1981
PERSONAL SKILLS
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Mother tongue(s) Foreign language(s)
English
Job-related skills
Italian
UNDERSTANDING Listening
WRITING
SPEAKING
Reading
Spoken interaction
Spoken production
C1 C2 C1 C1 C2
Levels: A1 and A2: Basic user - B1 and B2: Independent user - C1 and C2: Proficient user
Common European Framework of Reference for Languages
REVIEW ACTIVITY
For the following Journals:
“Gastroenterology” “Hepatology”, “Journal of Hepatology”, “Digestive and Liver Disease”, “Proteomic”, Cellular and Molecular Life Sciences”, “Cell Death and Differentiation”, “Cell Death and Disease”, “Cell Biology International”, “Cell Proliferation”, “Gut”, “Journal of Cellular Biochemistry,”Oncotarget”, “Molecules”,” Gene”” Stem Cell Research's”, “International Journal of Molecular Sciences”,, “Gene Therapy and Molecular Biology”,” World Journal of Gastroenterology”,” Journal of Proteome Research”, “Cell Reports”, “Cancer letters”.
For the following organization:
European Research Council; MIUR; Ministero della Sanità; University of Naples and University of Padua
PATENTS
National and International Patent:“Genetically modified non human mammiferus cells, procedure of their production and use in toxic tests”. (Patent number: T82002A00729 ). Inventors: L. Amicone , MG.Sacco , P. Vezzoni, M. Tripodi. 14/08/2002. International extension: 15/02/2006.
National Patents: “Culture for maintenance, proliferation and differentiation of mammiferus cells”.Application number RM2003A000395 12/08/2003. Inventors: V. Bordoni, T. Alonzi, M. Tripodi. Property of IMNI, “L. Spallanzani” IRCCS: International extension in course.
Feb 08th 2019
SCIENTIFIC PUBLICATIONS 2009-2018:
1. 2009 Agrati C.,Cimini E.,Sacchi A.,Bordoni V.,Gioia C.,Casetti R.,Turchi F.,Tripodi M. and Martini F. “Activated Vg9Vd2 T cells trigger granulocytes functions via MCP-2 release" The Journal of Immunology.Jan 1;182(1):522-9.
2. 2009WegertM,LaMonicaN.,TripodiM.,AdlerG.,Dikopoulos N..” ImpairedInterferonTypeI Signalling in the Liver Modulates the Hepatic Acute Phase Response in Hepatitis C Virus Transgenic Mice” Journal of Hepatology. 2009Aug;51(2):271-8.
3. 2009CollettiM,CicchiniC.,ConigliaroA.,SantangeloL.,AlonziT.,Pasquini E., TripodiM, Amicone L. “Convergence of Wnt signaling on the HNF4a-driven transcription in controlling liver zonation” Gastroenterology. 2009 Aug;137(2):660-72.
4. 2009 Rossi M.N., Carbone M., Mostocotto C., Mancone C., Tripodi M, Maione R. and Amati P.: “Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial dna integrity”. J Biol Chem Nov 13;284(46):31616-24..
5. 2010 Mancone C., Conti B., Amicone L., Bordoni V., Cicchini C., Calvo L., Basulto Perdomo A., Fimia G.M., Tripodi M. and Alonzi T.: “Proteomic analysis reveals a major role of contact inhibition in the execution of hepatocyte terminal differentiation”. J of Hepatology, 2010 Feb;52(2):234-43I
6. 2010- Notari S, Mancone C, Sergi M, Gullotta F, Bevilacqua N, Tempestilli M, Urso R, Lauria FN, Pucillo LP, Tripodi M, Ascenzi Determination of antituberculosis drug concentration in human plasma by MALDI-TOF/TOF. IUBMB Life.2010May;62(5):387-93
7. 2010 Mancone C., Steindler C., Santangelo L., Simonte G., , Vlassi C., Longo M.A., D’Offizi G., Di Giacomo C., Pucillo L.P., Amicone L., Tripodi M, and Alonzi T.: “Hepatitis C Virus production requires apolipoprotein A-I and affects its association to the nascent low-density lipoproteins”. Gut. 2011 Mar;60(3):378-86. Epub 2010 Oct12
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Curriculum vitae
8. 2011- Santangelo L., Marchetti A., Cicchini C, Conigliaro A., Conti B. , Mancone C, Alonzi T., Amicone L., Tripodi M, “Hepatocyte identity implies stable repression of the mesenchymal program: a novel role for hepatocyte nuclear factor 4a”. Hepatology Jun;53(6):2063-74
9. 2012 Garibaldi F., Cicchini C. , Conigliaro A., Santangelo L., Cozzolino AM., Grassi G., Marchetti A., Tripodi M,., Amicone L.“An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness- inhibiting microRNAs Cell Death and Differentiation.. 2012 Jun;19(6):937-46. doi:10.1038/cdd.2011.175.
10. 2012 Vescovo T., Romagnoli A., Basulto Perdomo A., Corazzari M., Ciccosanti F., Aloni T., Nardacci R., Ippolito G., Tripodi M, Garcia-Monzon C., Lo Iacono O, Piacentini M.and Fimia G.M. “Protective role of autophagy in lipid dysfunction caused by Hepatitis C Virus”. Gastroenterology.2012 Mar;142(3):644-653.e3. doi: 10.1053/j.gastro.2011.11.033. Epub 2011 Dec7.
11. 2012 Mancone C, Montaldo C, Santangelo L, Di Giacomo C, Costa V, Amicone L, Ippolito G, Pucillo LP, Alonzi T, Tripodi M, “Ferritin Heavy Chain Is the Host Factor Responsible for HCV-Induced Inhibition of apoB-100 Production and Is Required for Efficient Viral Infection”.J Proteome Res. 2012 May 4;11(5):2786-97. Epub 2012 Apr10.
12. 2012PelosiE.,CastelliG.,Martin-PaduraI.,BordoniV.,SantoroS.,CerioAM.,ConigliaroA., Marighetti P., Desantis Puzzonia M., Biffoni M., Testa U., Amicone L., Alonzi T., Bertolini F., Peschle C., Tripodi M, “Human Haemato-endothelial Precursors: Cord blood CD34+ Cells Produce Haemogenic Endothelium” PLOS ONE. 2012; PLoS One. 2012;7(12) Epub 2012 Dec4.
13. 2013CozzolinoAM,AlonziT,SantangeloL,ManconeC,ContiB,SteindlerC,MusoneM,Cicchini C, Tripodi M, and Marchetti A. “TGFbeta overrides HNF4alpha tumor suppressing activity through GSK-3beta inactivation: implication for hepatocellular carcinoma gene therapy” J. Hepatol Jan;58(1):65-72
14. 2013ManconeC,CiccosantiF,MontaldoC,PerdomoAB,PiacentiniM,AlonziT,Fimia
GM, Tripodi M, Applying proteomic technology to clinical virology” Clin Microbiol Infect. 2012 Sep24.
15. 2013MarraE,TurriniP,TripodiM,,CilibertoG,PadronJ,AurisicchioL.”Intrablastocystinjection with human CD34+/CD133+ cells increase survival of immunocompetent fumarylacetoacetate hydrolase knockout mice”. Lab Anim. 2012Oct;46(4).
16. 2013ConigliaroA,AmiconeL,CostaV,DeSantisPuzzonaM,ManconeC,SacchettiB,Cicchini C,GaribaldiF,BrennerD.A,KisselevaT,BiancoPandTripodiM,“Evidence foracommonprogenitor of epithelial and mesenchymal components of the liver” Cell Death and Differentiation 2013 Aug;20(8):1116-23.. Epub 2013 May 17.
17. 2013MarchettiA.,CicchiniC.,SantangeloL.,CozzolinoAM.,CostaV.,TripodiM.,AmiconeL. “Networks controlling HCC on set and progression:influence of microenviroment and in gene therapy”. Journal of Cancer Therapy 4,353-358.
18. 2013ParoliM,BellatiF,VidettaM,FocaccettiC,ManconeC,DonatoT,AntonilliM,PerniolaG, Accapezzato D, Napoletano C, Nuti M, Bartolazzi A, Panici PB, Tripodi M, Palombo F, Barnaba V. “Discovery of chemotherapy-associated ovarian cancer antigens by interrogating memory T cells.” Int J Cancer. 2014 Apr 15;134(8):1823-34. doi: 10.1002/ijc.28515. Epub 2013 Oct 22. Erratum in: Int J Cancer. 2014 Jul15;135(2):E1.
19. 2014MontaldoC,MatteiS.,BaiocchiniA.,RotirotiN.,DelNonnoF.,PucilloL.P.,CozzolinoA.M., Battistelli C., Amicone L., Ippolito G., van Noort V., Conigliaro A., Alonzi T., Tripodi M., Mancone C. ” Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in Hepatitis C infections with hepatic iron overload” Proteomics 2014May;14(9):1107-15.
20. 2014CicchiniC,AmiconeL,AlonziT,MarchettiA,ManconeC,TripodiM.“Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte.” Liver Int. 2015 Feb;35(2):302-10. doi: 10.1111/liv.12577. Epub 2014 May20.
21. 2014 Montaldo C., Mancone C., Conigliaro A., Cozzolino A.M., de Nonno V., Tripodi M. “SILAC labeling coupled to shotgun proteomics analysis of membrane proteins of liver stem/hepatocyte allows to candidate the inhibition of TGF-beta pathway as causal to differentiation.” Proteome Sci. 2014 Mar15;12(1):15.
22. 2014 Castelli G, D'Angiò A, Grassi G, Costa V, Pasquini L, Tiberio R, Cerio AM, Testa U, Tripodi M, Pelosi “Human cord blood-derived hemogenic endothelium generates mast cells”Blood Cells Mol Dis. 2015Feb;54(2):195-7.
23. 2015PinzagliaM,MontaldoC,PolinariD,SimoneM,LaTeanaA,TripodiM,ManconeC,Londei P, Benelli D. “eIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins” BMC Cancer. 2015
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Mar15;15:13.
24. 2015CicchiniC,deNonnoV,BattistelliC,CozzolinoAM,DeSantisPuzzoniaM,CiafrèSA, Brocker C, Gonzalez FJ, Amicone L, Tripodi M “Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. Biochim Biophys Acta. Gene Regulatory Mechanisms. 2015 May21.
25. 2015ConigliaroA,CostaV,LoDicoA,SaievaL,BuccheriS,DieliF,MannoM,RaccostaS, Mancone C, Tripodi M, De Leo G, Alessandro R. “CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA.”Mol Cancer. 2015 Aug 14;14:155.
26. 2015. Grassi G, Di Caprio G, Santangelo L, Fimia GM, Cozzolino AM, Komatsu M, Ippolito G, Tripodi M, Alonzi Autophagy regulates hepatocyte identity and epithelial-to- mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation. Cell Death Dis. 2015 Sep10;6:e1880.
27. 2015. Cozzolino A., Noce V., Battistelli C., Marchetti A., Grassi G., Cicchini C., Tripodi M. and Amicone L. "Modulating the substrate stiffness to manipulate differentiation of Resident Liver Stem Cells and to improve the differentiation state of hepatocytes". Stem Cellinternational
28. 2016.GrassiG,DiCaprioG,FimiaGM,IppolitoG,TripodiM,AlonziT.“HepatitisCvirusrelieson lipoproteins for its life cycle.” World J Gastroenterol. 2016 Feb 14;22(6):1953-65. doi: 10.3748/wjg.v22.i6.1953.Review.
29. 2016.BaiocchiniA,MontaldoC,ConigliaroA,GrimaldiA,CorreaniV,MuraF,CiccosantiF, Rotiroti N, Brenna A, Montalbano M, D'Offizi G, Capobianchi MR, Alessandro R, Piacentini M, Schininà ME, Maras B, Del Nonno F, Tripodi M, Mancone C. PLoS One. 2016 Mar 21;11(3):e0151736. doi: 10.1371/journal.pone.0151736. eCollection2016.
30. 2016.LoDicoA,CostaV,MartelliC,DiceglieC,RajataF,RizzoA,ManconeC,TripodiM, Ottobrini L, Alessandro R, Conigliaro A. “MiR675-5p Acts on HIF-1αto Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma.” Theranostics. 2016 May 8;6(8):1105-18. doi: 10.7150/thno.14700. eCollection2016
31. 2016SantangeloL,GiuratoG.,CicchiniC.,ClaudiaMontaldoC.,ManconeC.,TaralloR., Battistelli C. , Alonzi T., Weisz A. and Tripodi M., "The RNA binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNAssorting" Cell Rep. 2016 Oct 11;17(3):799-808. doi:10.1016/j.celrep.2016.09.03
32. 2016DeSantisPuzzoniaM,CozzolinoAM,GrassiG,BiscegliaF,StrippoliR,GuarguagliniG, Citarella F, Sacchetti B, Tripodi M, Marchetti A, Amicone L., “TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure”. PLoS One. 2016 Nov 28;11(11):e0167158. doi: 10.1371/journal.pone.0167158. eCollection 2016.
33. 2017CicchillittiL,ManniI,ManconeC,RegazzoG,SpagnuoloM,AlonziT,CarlomostiF, Dell'Anna ML, Dell'Omo G, Picardo M, Ciana P, Capogrossi MC, Tripodi M, Magenta A, Rizzo MG, Gurtner A, Piaggio G., “The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation”. Oncotarget. 2017 Jan 10;8(2):2628-2646. doi: 10.18632/oncotarget.12914
34. 2017OrecchiniE,DoriaM,AntonioniA,GalardiS,CiafrèSA,FrassinelliL,ManconeC,Montaldo C, Tripodi M, Michienzi A. ADAR1 restricts LINE-1 retrotransposition. Nucleic Acids Res. 2017 Jan 9;45(1):155-168. doi: 10.1093/nar/gkw834. Epub 2016 Sep21.
35. 2017BattistelliC,CicchiniC,SantangeloL,TramontanoA,GrassiL,GonzalezFJ,deNonnoV, Grassi G, Amicone L,Tripodi M. ”The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to- mesenchymal transition.” Oncogene. 2017 Feb 16;36(7):942-955. doi: 10.1038/onc.2016.260. Epub 2016 Jul 25.
36. 2017CostaV,LoDicoA,RizzoA,RajataF,TripodiM,AlessandroR,ConigliaroA.“MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells”. Oncotarget. 2017 Apr 11;8(15):24292-24302. doi: 10.18632/oncotarget.14464.
37. 2017CostanzoG,GiorgiA,ScipioniA,TimperioAM,ManconeC,TripodiM,KapralovM, Krasavin E, Kruse H, Šponer J, Šponer JE, Ranc V, Otyepka M, Pino S, Di Mauro E. “Nonenzymatic Oligomerization of 3',5'-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA”. Chembiochem. 2017 Aug 4;18(15):1535-1543. doi: 10.1002/cbic.201700122. Epub 2017 Jun 30.
38. 2017ManconeC,GrimaldiA,RefoloG,AbbateI,RozeraG,BenelliD,FimiaGM,BarnabaV, Tripodi M, Piacentini M, Ciccosanti F. “Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes”. Proteome Sci. 2017 Aug 4;15:18. doi: 10.1186/s12953-017-
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Curriculum vitae
0126-0. eCollection2017.
39. 2017BattistelliC,TripodiM,CicchiniC.“TargetingofpolycombstoDNAin EMT”.Oncotarget. 2017 Aug 12;8(35):57936-57937. doi: 10.18632/oncotarget.20211. eCollection 2017 Aug29.
40. 2017ConigliaroA,TripodiM,ParolaM.SENP1activitysustainscancerstemcellinhypoxic HCC. Gut. 2017 Dec;66(12):2051-2052. doi: 10.1136/gutjnl-2017-313946. Epub 2017 Apr13
41. 2018RefoloG,CiccosantiF,DiRienzoM,PerdomoAB,RomaniM,AlonziT,TripodiM,Ippolito G, Piacentini M, Fimia GM.Negative regulation of MAVS-mediated antiviral signaling by the mitochondrial protein LRPPRC during HCV infectionHepatology. 2018 Aug 2. doi: 10.1002/hep.30149. [Epub ahead of print]
42. 2018SantangeloL,BordoniV,MontaldoC,CiminiE,ZingoniA,BattistelliC,
D'Offizi G, Capobianchi MR, Santoni A, Tripodi M, Agrati C. Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties.Liver Int. 2018 Oct;38(10):1741-1750. doi: 10.1111/liv.13700. Epub 2018 Feb24.
43. 2018ManconeC,GrimaldiA,RefoloG,AbbateI,RozeraG,BenelliD,FimiaGM,BarnabaV, Tripodi M, Piacentini M, Ciccosanti F.Iron overload down-regulates the expression of the HIV- 1 Rev cofactor eIF5A in infected Tlymphocytes. Proteome Sci. 2017 Aug 4;15:18. doi: 10.1186/s12953-017- 0126-0. eCollection 2017.
44. 2018 Battistelli C, Sabarese G, Santangelo L, Montaldo C, Gonzalez FJ, Tripodi M, Cicchini C.The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation.Cell Death Differ. 2018 Aug 28. doi: 10.1038/s41418-018-0170-z. [Epub ahead of print]PMID:30154449
45. 2018RossiL,BattistelliC,deTurrisV,NoceV,ZwergelC,ValenteS,MoioliA,ManzioneA, Palladino M, Bordoni V, Domenici A, Menè P, Mai A, Tripodi M, Strippoli R. HDAC1 inhibition by MS- 275 in mesothelial cells limits cellular invasion and promotes MMT reversal. Sci Rep. 2018 May 31;8(1):8492. doi:10.1038/s41598-018-26319-2.
46. 2018HoborF,DallmannA,BallNJ,CicchiniC,BattistelliC,OgrodowiczRW,ChristodoulouE, Martin SR, Castello A, Tripodi M, Taylor IA, Ramos A. “A cryptic RNA- binding domain mediates Syncrip recognition and exosomal partitioning ofmiRNAtargets.” Nat Commun. Feb 26;9(1):831. doi: 10.1038/s41467-018-03182-3.
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