ALTIERI FABIO

Professore Ordinario 
Settore scientifico disciplinare di riferimento  (BIO/10)
Ateneo Università degli Studi di ROMA "La Sapienza" 
Struttura di afferenza Dipartimento di SCIENZE BIOCHIMICHE "ALESSANDRO ROSSI FANELLI" 
Recapiti Elenco recapiti telefonici
E-Mail fabio.altieri@uniroma1.it

Orari di ricevimento

Lun e Ven 11-13 - Mar 15-17 Altri giorni su appuntamento Dipartimento Scienze Biochimiche (Edificio CU027) piano 2, stanza 202

Curriculum

Dr. Fabio Altieri got on 1981 his Master degree in Biology with honors from the University of Rome Sapienza. On 1986 he got the Ph.D. in Biochemistry, Department of Biochemical Sciences, University of Rome Sapienza. From 1987 to 1989 he worked for two years as Researcher at the School of Basic Life Sciences, University of Missouri-Kansas City – USA. On 1991 he was appointed as Researcher, working at the Department of Biochemical Sciences, Sapienza University of Rome and in 2000 was promoted to Associate Professor in Biochemistry, Faculty of Pharmacy, Sapienza University of Rome. Since 2006 is Full Professor in Biochemistry, Faculty of Pharmacy and Medicine, Department of Biochemical Sciences, Sapienza University of Rome. He conducted his research working initially on the characterization of non-histone chromosomal proteins. After that he focused the attention on nuclear protein purification and characterization, protein-protein and protein-DNA interactions. Current research cover the analysis of protein involved in signal transduction, cancer onset and progression, and oxidative stress response, as well as the screening of bioactive compounds and their impact on protein functionality.
Keywords: oxidative stress, cellular biochemistry, signal transduction, protein-ligand interaction, bioactive compounds
ORCID: 000-0002-6546-2738
Selected publications:
Giamogante F, Marrocco I, Cervoni L, Eufemi M, Chichiarelli S, Altieri F.
Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity.
Biochimie. 2018 Feb 6. pii: S0300-9084(18)30034-8. doi: 10.1016/j.biochi.2018.01.008.
Battisti F, Napoletano C, Rahimi Koshkaki H, Belleudi F, Zizzari IG, Ruscito I, Palchetti S, Bellati F, Benedetti Panici P, Torrisi MR, Caracciolo G, Altieri F, Nuti M, Rughetti A.
Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells.
Front Immunol. 2017 Sep 25;8:1179. doi: 10.3389/fimmu.2017.01179. eCollection 2017.
Marrocco I, Altieri F, Peluso I.
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans.
Oxid Med Cell Longev. 2017;2017:6501046. doi: 10.1155/2017/6501046. Epub 2017 Jun 18. Review.
Cocchiola R, Romaniello D, Grillo C, Altieri F, Liberti M, Magliocca FM, Chichiarelli S, Marrocco I, Borgoni G, Perugia G, Eufemi M.
Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score.
Oncotarget. 2017 Jun 27;8(26):42560-42570. doi: 10.18632/oncotarget.17245.
Coccurello R, Romano A, Giacovazzo G, Tempesta B, Fiore M, Giudetti AM, Marrocco I, Altieri F, Moles A, Gaetani S.
Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat.
Eur J Nutr. 2017 Mar 17. doi: 10.1007/s00394-017-1434-y.
Giamogante F, Marrocco I, Romaniello D, Eufemi M, Chichiarelli S, Altieri F
Comparative Analysis of the Interaction between Different Flavonoids and PDIA3
Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 4518281, 12 pages, 2016.
doi:10.1155/2016/4518281
Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, Eufemi M, Chichiarelli S.
Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.
Sci Rep. 2016 Nov 29;6:37957.
doi: 10.1038/srep37957. PubMed PMID: 27897272.
Cocchiola R, Grillo C, Altieri F, Chichiarelli S, Turano C, Eufemi M.
Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
PLoS One. 2014 Nov 17;9(11):e113096.
doi: 10.1371/journal.pone.0113096. PubMed PMID:25401333; PubMed Central PMCID: PMC4234655.
Peluso I, Manafikhi H, Altieri F, Zanza C, Palmery M.
The effect of sample storage on the Peroxidation of Leukocytes Index Ratio (PLIR) measure.
Sci Rep. 2014 Oct 7;4:6539.
doi: 10.1038/srep06539. PubMed PMID: 25290094.
Bedse G, Colangeli R, Lavecchia AM, Romano A, Altieri F, Cifani C, Cassano T, Gaetani S.
Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. Eur
Neuropsychopharmacol. 2014 Sep;24(9):1511-23.
doi:10.1016/j.euroneuro.2014.07.005. PubMed PMID: 25106694.
Grillo C, Chichiarelli S, Gaucci E, Altieri F, Turano C, Cervoni L.
The binding of silibinin to ERp57.
Chem Biol Interact. 2014 Apr 25;213:37-43.
doi:10.1016/j.cbi.2014.02.005. PubMed PMID: 24530445.
Bedse G, Romano A, Cianci S, Lavecchia AM, Lorenzo P, Elphick MR, Laferla FM, Vendemiale G, Grillo C, Altieri F, Cassano T, Gaetani S.
Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease.
J Alzheimers Dis. 2014;40(3):701-12.
doi: 10.3233/JAD-131910. PubMed PMID: 24496074.
Cocchiola R, Grillo C, Altieri F, Chichiarelli S, Turano C, Eufemi M.
Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
PLoS One. 2014, 9(11):e113096. doi: 10.1371/journal.pone.0113096.
Grillo C, Chichiarelli S, Gaucci E, Altieri F, Turano C, Cervoni L.
The binding of silibinin to ERp57.
Chem Biol Interact. 2014, 213:37-43. doi: 10.1016/j.cbi.2014.02.005.
Gaucci E, Altieri F, Turano C, Chichiarelli S.
The protein ERp57 contributes to EGF receptor signaling and internalization in MDA-MB-468 breast cancer cells.
J Cell Biochem. 2013, 114(11):2461-70. doi: 10.1002/jcb.24590.
Trnková L, Ricci D, Grillo C, Colotti G, Altieri F.
Green tea catechins can bind and modify ERp57/PDIA3 activity.
Biochim Biophys Acta 2013, 1830:2671-2682.
Sciandra F, Angelucci E, Altieri F, Ricci D, Hübner W, Petrucci TC, Giardina B, Brancaccio A, Bozzi M.
Dystroglycan is associated to the disulfide isomerase ERp57.
Exp Cell Res. 2012, 318: 2460-2469.
Frasconi M, Chichiarelli S, Gaucci E, Mazzei F, Grillo C, Chinazzi A, Altieri F.
Interaction of ERp57 with calreticulin: Analysis of complex formation and effects of vancomycin.
Biophys Chem. 2012, 160(1):46-53. doi: 10.1016/j.bpc.2011.09.003.
Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G.
Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.
Mol Biol Cell. 2011, 22: 3887-3901.