VILLANI CLAUDIO

Professore Ordinario 
Settore scientifico disciplinare di riferimento  (CHIM/06)
Ateneo Università degli Studi di ROMA "La Sapienza" 
Struttura di afferenza Dipartimento di CHIMICA E TECNOLOGIE DEL FARMACO 
Recapiti Elenco recapiti telefonici

Orari di ricevimento

Lunedì h 9-11. Dipartimento di Chimica e Tecnologie del Farmaco, Edificio “V.
Caglioti” CU032, piano 3°, stanza 4.

Curriculum

Claudio Villani
Full Professor of Organic Chemistry, University of Roma “La Sapienza”
Department of Chemistry and Technology of Drugs, P.le A. Moro 5 – 00185 Roma, Italy
E-mail: claudio.villani@uniroma1.it
Orcid ID: 0000-0002-3253-3608; Researcher ID: D-9285-2011; Scopus Author ID: 7102147503
Education
1984 – Master Degree (Laurea) in Pharmaceutical Chemistry and Technology, University of Roma “La Sapienza”, Italy.
1988 – PhD Pharmaceutical Sciences, University of Roma “La Sapienza”, Italy
Fellowships
1984-1985 – Farmindustria, Organic Chemistry Institute, University of Roma “La Sapienza”, Italy.
Professional appointments
1988-1998 – Research Associate, University of Rome
1993-1994 – Research Associate, School of Chemical Science, UIUC, USA
1998-2002 – Associate Professor of Organic Chemistry, University of Chieti-Pescara
2000-2006 – Associate Professor of Organic Chemistry, University of Rome “La Sapienza”
2006 – Full Professor of Organic Chemistry, University of Rome “La Sapienza”

Research interests
Claudio Villani is full professor of Organic Chemistry at University of Roma “La Sapienza”, Chemistry and Technology of Drugs Department. His main interests are in the field of organic stereochemistry, with emphasis on the application of chromatography and spectroscopy (NMR, CD, MS) to problems in static and dynamic stereochemistry. He has been involved in the design, synthesis, characterization and commercialization of chiral stationary phases for HPLC applications.
Scientific achievements
Claudio Villani obtained his Laurea degree in Pharmaceutical Chemistry and Technology in 1984 in the group of Francesco Gasparrini, working on the synthesis of silica based chiral stationary phases (CSPs) for HPLC applications. In the following years, he continued to work on the same topic, developing a series of CSPs incorporating small synthetic chiral molecules (Chromatographia 1987, JCA 1988), synthetic macrocycles (JOC 1995, 1997), macrocyclic antibiotics (Anal Chem 2000, JCA 1999), polyamides (JCA 2005). Part of the activity was done at the School of Chemical Science-University of Urbana Champaign working with prof. W.H. Pirkle during the years 1993-94. Chiral-racemic or non-chiral HPLC silica based hybrid materials incorporating fullerenes (JACS 1997) or carbon nanotubes (Carbon 2006) were prepared and used to study the interaction of the carbon fragments with several guest probes. Recent activity in the field has seen the first introduction of small particles for ultra-high performance applications (JCA 2010, Anal chem 2012, TrAC 2014). Insights of the molecular recognition mechanisms that govern enantioselectivity in LC systems have been derived from free solution studies and molecular modelling (J. Comp. Chem. 2000, 2007, EurJOC 2011). Parallel studies in the gas phase were subsequently performed using small macrocyclic amide receptors that showed unprecedented enantioslectivity towards small aminoacidic guests. Investigations in this area were conducted on electrospray generated proton bound host-guest dimers and trimers and observing their gas phase behavior upon collision induced dissociation or gas-phase guest exchange reactions (JACS 2005, 2008; Chem Commun 2009, Chem Eur J 2011). Claudio Villani gave a substantial contribution to the stereodynamic investigation of chiral species, including drugs or drug like molecules (JACS 1992, 2000; JOC 1995; Tet Asym 1997, Chem Commun 2012; JCA 2014), featuring labile stereogenic elements. A combination of techniques are used to extract kinetic data, including on-column dynamic HPLC, dynamic NMR, off-column thermal isomerization, stopped-flow CD. These studies have direct relevance both in setting and consolidating experimental approaches, and in providing dynamic structural details of chiral species.
Bibliometric indicators
Number of papers on peer-reviewed journals: 159; book-chapters: 8.
Source: Google Scholar, number of citations 4550; h-index=41; i10-index=112; h-index (since 2014)=21; i10-index (since 2014)=44.
Source: WoS h-index=37, 3850 citations);
Source: Scopus h-index=38 , 4060 citations)
Supervision of graduate students and postdoctoral fellows
1998-2017 – 3 postdocs, 6 PhD students, 20 Master students – University of Chieti-Pescara and Roma “La Sapienza”
Organisation of scientific meetings
Since 2010 Claudio Villani is a member of the permanent scientific committee of the International Meeting on Chiral Discrimination ISCD- Chirality series. As such, he was involved in the organization of the following symposia: 2011 Liverpool, 2012 Fort Worth TX, 2013 Shanghai, 2014 Prague, 2015 Boston, 2016 Heidelberg, 2017 Tokyo.
Summer School "A. Corbella" Seminars in Organic Synthesis, organizing committee, Gargnano, Italy. 2009-11
ChirItaly co-chair 2014 Pisa, 2015 Roma, 2016 Catania
Institutional responsibilities
2010- Faculty of Pharmacy and Medicine, Vice Dean
2016- Biotechnology degree - President
2016-2018 member of the national committee for National Scientific Qualification
2018- PhD Couse “Pharmaceutical Sciences”, Coordinator
Collaborative projects
Ministry of University and Research, PRIN 2004, 2005. 2009 local PI, 2012 local PI.
Commissions of trust
Since 2006 editorial board member of the journal: Chirality
2014- projects evaluator for Ministry of University and Research, PRIN, SIR
2015 projects evaluator for Austrian Science Fund (FWF) , Austria
2016 projects evaluator for Austrian Science Fund (FWF) , Austria
2015 projects evaluator for Czech Academy of Sciences (CAS)
2013-15 project evaluator– Italian- French University Galileo and Vinci projects
2010-2017 scientific advisor for Merck-Serono, Merck, Supelco Sigma-Aldrich
Regular reviewer activity for scientific chemistry journals published by Wiley, Elsevier, American Chemical Society.
Memberships of scientific societies
Italian Chemical Society; American Chemical Society
Major collaborations
M. Speranza (gas phase enantioselectivity, U. of Roma “La Sapienza”), S. Abbate (configurational assignements by ECD, VCD, CPL studies, U. of Brescia), W. Chalifoux (helilcenes, twisted polycyclic aromatics, U. of Nevada, Reno), M. Prato (fullerene and carbon nanotubes, U. of Trieste), J. Vos (chiral Ru complexes, photochemistry, U. of Dublin), W. Browne (chiral Ru complexes, photochemistry, U. Of Groningen), P. Stephens (absolute configuration by VCD, U. South California), J. Lacour (helicenes, U. of Geneva).

Patents
- F. Gasparrini, D. Misiti, C. Villani "Fasi stazionarie chirali a largo spettro contenenti N,N'-(pentafluorobenzoyl)-trans-1,2-diamminocicloesano come selector per la risoluzione diretta di racemati mediante HPLC, procedimento per la loro preparazione ed uso" Italian patent, C.N.R., filed on 29/8/1989, N° 21583A
- F. Gasparrini, D. Misiti, C. Villani "Fasi stazionarie chirali a largo spettro contenenti N,N'-(3,5-dinitrobenzoyl)-trans-1,2-diamminocicloesano come selector per la risoluzione diretta di racemati mediante HPLC, procedimento per la loro preparazione ed uso" Italian patent, C.N.R., filed on il 29/8/1989, N° 21584A
- F. Gasparrini, D. Misiti, C. Villani “Nuovi macrocicli tetrammidici, procedimento per la loro preparazione e loro uso come recettori in fasi stazionarie chirali” Italian patent Università La Sapienza, filed on 21/4/2001, N° RM2000A000221
- F. Gasparrini, D. Misiti, C. Villani “Fasi Stazionarie Chirali Polimeriche Tipo Brush” Brevetto Italiano Università La Sapienza, presentato il 20/03/2002, N° RM2002A000155 - PCT Int. Appl. (2003), WO 2003079002 A2 20030925 - Assigned to Astec Inc., Whippany, NJ, USA
- A. Nunziata, G. Lionetti, E. Pierri, B. Botta, G. Cancelliere, I. D'acquarica, G. Delle Monache, F. Gasparrini, L. Nevola, D. Subissati, C. Villani. (2006). Use of resorcinarenes in smoke filtration. PCT Int. Appl. (2006), WO 2006136950 A1 20061228
- G. Angelini, O. Ursini, F. Gasparrini, C. Villani “Colonne cromatografiche ad elevate prestazioni contenenti supporti monolitici polimerici organici o compositi e relativo metodo di preparazione” Italian patent, filed on 28/12/2006, N° RM2006 A000723
- Chiara Di Meo, Claudio Villani, Pietro Matricardi “Nuova Piattaforma Polimerica per la Preparazione di Nanoidrogel” Italian patent, C.N.R., filed on 15/1/2013, RM2013A000631
- P Matricardi, C Di Meo, C Villani NOVEL POLYMER PLATFORM TO PREPARE NANOHYDROGEL- US Patent 20,160,289,394, 2016 –
Technological Transfer: partecipation to spin-off MoLiRom srl (Roma).
Invited presentations to peer-reviewed internationally established conferences and/or international advanced schools
3rd International Symposium on Chiral Discrimination, Tubingen 1992
XIX Summer School "A. Corbella", Gargnano 1994
5th International Symposium on Chiral Discrimination, Stoccolma, 1994
18th International Symposium on Capillary Chromatography, Riva del Garda, 1996
8th International Symposium on Chiral Discrimination, Edinburgh, 1996
10th International Symposium on Chiral Discrimination, Vienna, 1998
3rd Spanish-Italian Symposium on Organic Chemistry, Malaga 2000 (invited lecture)
Molecular Chirality Symposium 2003, Shizuoka, Japan 2003 (invited lecture)
4th Franco-Italian Meeting on Organic Chemistry, Annecy, France 2004 (invited lecture)
16th International Symposium on Chirality, New York, USA 2004 (invited lecture)
18th International Symposium on Chirality, Busan, Korea, 2006
Enantiosep - Ferrara, Italy 2007
11th International Conference on Circular Dichroism - Groningen, The Netherlands, 2007
20th International Symposium on Chirality, Geneva, Switzerland, 6-9 Luglio 2008
Molecular Chirality Symposium 2010 , Sapporo, Japan, 2010
18th International Symposium on Electro- and Liquid Phase-separation Techniques,Tbilisi 2011
24th International Symposium on Chirality, Fort Worth, TX, USA, 2012
Molecules at the mirror: Chirality in Chemistry and biophysics. Accademia dei Lincei, Roma 2012
14th International Conference on Chiroptical Spectroscopy – Nashville, Tennessee 2013
26th International Symposium on Pharmaceutical and Biomedical Analysis, Tbilisi, Georgia 2015
28th International Symposium on Chirality, Heidelberg, Germany 24-27 Luglio 2016
37th National meeting, Organic Chemistry Division of Italian Chemical Society, Venezia 2016 (keynote)
Institutional teaching activity at University of Chieti–Pescara and University of Roma “La Sapienza” Organic Chemistry for students of Pharmacy; Organic Chemistry for students of Biotechnology; Physical Methods in Organic Chemistry for students of Pharmaceutical Chemistry and Technology; Organic Stereochemistry for Pharmaceutical Chemistry and Technology.