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Prof. Carmine Mancone is the manager of the Tumor Microenvironment Laboratory at Sapienza University of Rome. The laboratory works on understanding the molecular basis of the interaction between cancer cells and the tumor microenvironment in liver and biliary tract carcinomas. In particular, the studies focus on the identification of proteins responsible for the remodeling of the extracellular matrix, for the regulation of vascular and lymphatic angiogenesis and for the desmoplastic reaction to understand how the microenvironment influences growth, invasiveness, and metastasis of cancer cells and to identify new therapeutic targets.
The professor Mancone collaborates with the anti-mafia magazine “I Siciliani Giovani” writing articles on the Italian university system.
| Insegnamento | Codice | Anno | Corso - Frequentare | Bacheca |
|---|---|---|---|---|
| BIOLOGIA E GENETICA | 1035248 | 2023/2024 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2023/2024 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2023/2024 | ||
| BIOLOGIA E GENETICA | 1035248 | 2022/2023 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2022/2023 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2022/2023 | ||
| BIOLOGIA E GENETICA | 1035248 | 2021/2022 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2021/2022 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2021/2022 | ||
| BIOLOGIA E GENETICA | 1035248 | 2020/2021 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2020/2021 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2020/2021 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2019/2020 | ||
| BASI CELLULARI E MOLECOLARI DELLA VITA | 1035043 | 2019/2020 | ||
| BIOLOGIA E GENETICA | 1035248 | 2019/2020 | ||
| BIOLOGIA E GENETICA | 1035248 | 2018/2019 | ||
| BIOLOGIA E GENETICA | 1035248 | 2017/2018 | ||
| BIOLOGIA E GENETICA | 1035248 | 2016/2017 |
Su richiesta contattando il docente al seguente indirizzo di posta elettronica: carmine.mancone@uniroma1.it
PERSONAL DATA
SURNAME: Mancone
NAME: Carmine
PLACE AND DATE OF BIRTH: Pontecorvo (Fr, Italy), 10/02/1978
CITIZENSHIP: Italian
WORK ADDRESS: Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Torre di Ricerca, 1st Floor, Room 37
E-MAIL: carmine.mancone@uniroma1.it
WEB SITE: https://research.uniroma1.it/tumor-microenvironment-laboratory
EDUCATION
- University of Rome La Sapienza , Rome, Italy, Ph.D., Human Biology and Genetics, February 2007
- University of Rome La Sapienza , Rome, Italy, Degree (Lauream, Summa cum laude) in Biology, November 2002
ACTUAL POSITION
- Associate Professor, Sapienza University of Rome, Italy.
- Director of the Tumor Microenvironment Laboratory
RESEARCH EXPERIENCES
- 01/11/2003-31/10/2006. PhD felloship in Human Biology and Genetics, Sapienza University of Rome, laboratory of Experimental Hepatology.
- 01/11/2006-30/06/2015. Research assistant of National Institute for Infectious Disease L. Spallanzani IRCCS Rome, - Laboratory of Gene Expression and Experimental Hepatology.
01/07/2012-31/01/2019. Research worker (RTD), Sapienza University of Rome, Department of Molecular Medicine.
RESEARCH ACTIVITY
Prof. Carmine Mancone is the manager of the Tumor Microenvironment Laboratory. The laboratory works on understanding the molecular basis of the interaction between cancer cells and the tumor microenvironment in liver and biliary tract carcinomas. The research activity is mainly focused on the identification and characterization of proteins responsible for the remodeling of the extracellular matrix (ECM), for the regulation of vascular and lymphatic angiogenesis and for the desmoplastic reaction in cholangiocarcinoma to understand how the tumor microenvironment (TME) influences growth, invasiveness, and metastasis of cancer cells and to identify new therapeutic targets.
PUBLICATIONS
1. Colasanti T, Di Giamberardino A, Grimaldi A, Cardinale V, Carpino G, Mancone C. Letter to the editor: Serum thrombospondin-2 as biomarker in liver diseases, a look beyond NASH. Hepatology. 2022;75:1056-1057.
2. de Jong IEM, Overi D, Carpino G, Gouw ASH, van den Heuvel MC, van Kempen LC, Mancone C, Onori P, Cardinale V, Casadei L, Alvaro D, Porte RJ, Gaudio E. Persistent Biliary Hypoxia and Lack of Regeneration Are Key Mechanisms in the Pathogenesis of Post-transplant Non-anastomotic Strictures. Hepatology. 2022;75:814-830.
3. Carpino G, Cardinale V, Di Giamberardino A, Overi D, Donsante S, Colasanti T, Amato G, Mennini G, Franchitto M, Conti F, Rossi M, Riminucci M, Gaudio E, Alvaro D, Mancone C. Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma. J Hepatol. 2021;75:1377-1386.
4. Cervoni M, Lo Sciuto A, Bianchini C, Mancone C, Imperi F. Exogenous and Endogenous Phosphoethanolamine Transferases Differently Affect Colistin Resistance and Fitness in Pseudomonas aeruginosa. Front Microbiol. 2021;12:778968.
5. Frassinelli L, Orecchini E, Al-Wardat S, Tripodi M, Mancone C, Doria M, Galardi S, Ciafrè SA, Michienzi A. The RNA editing enzyme ADAR2 restricts L1 mobility. RNA Biol. 2021;18:75-87.
6. Ghirga F, Stefanelli R, Cavinato L, Lo Sciuto A, Corradi S, Quaglio D, Calcaterra A, Casciaro B, Loffredo MR, Cappiello F, Morelli P, Antonelli A, Rossolini GM, Mangoni M, Mancone C, Botta B, Mori M, Ascenzioni F, Imperi F. A novel colistin adjuvant identified by virtual screening for ArnT inhibitors. J Antimicrob Chemother. 2020;75:2564-2572.
7. Grimaldi A, Cammarata I, Martire C, Focaccetti C, Piconese S, Buccilli M, Mancone C, Buzzacchino F, Berrios JRG, D'Alessandris N, Tomao S, Giangaspero F, Paroli M, Caccavale R, Spinelli GP, Girelli G, Peruzzi G, Nisticò P, Spada S, Panetta M, Letizia Cecere F, Visca P, Facciolo F, Longo F, Barnaba V. Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens. Commun Biol. 2020;3:85.
8. Lo Sciuto A, Cervoni M, Stefanelli R, Mancone C, Imperi F. Effect of lipid A aminoarabinosylation on Pseudomonas aeruginosa colistin resistance and fitness. Int J Antimicrob Agents. 2020;55:105957.
9. Colasanti T, Sabatinelli D, Mancone C, Giorgi A, Pecani A, Spinelli FR, Di Giamberardino A, Navarini L, Speziali M, Vomero M, Barbati C, Perricone C, Ceccarelli F, Finucci A, Celia AI, Currado D, Afeltra A, Schininà ME, Barnaba V, Conti F, Valesini G, Alessandri C. Homocysteinylated alpha 1 antitrypsin as an antigenic target of autoantibodies in seronegative rheumatoid arthritis patients. J Autoimmun. 2020:102470.
10. Renzi P, Mazzapioda L, Nardelli F, Martini F, Geppi M, Mancone C, Navarra MA, D'Acunzo F, Gentili P. Titanium Based Tetrakis 2,3 [5,6 di(Substituted)pyrazino]porphyrazine: Synthesis and Characterization. European Journal of Inorganic Chemistry 2020;25:2417-23.
11. Carpino G, Overi D, Melandro F, Grimaldi A, Cardinale V, Di Matteo S, Mennini G, Rossi M, Alvaro D, Barnaba V, Gaudio E, Mancone C. Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure. Clin Proteomics. 2019;16:37.
12. Lo Sciuto A, Cervoni M, Stefanelli R, Spinnato MC, Di Giamberardino A, Mancone C, Imperi F. Genetic Basis and Physiological Effects of Lipid A Hydroxylation in Pseudomonas aeruginosa PAO1. Pathogens. 2019;8:291.
13. Del Ben M, Overi D, Polimeni L, Carpino G, Labbadia G, Baratta F, Pastori D, Noce V, Gaudio E, Angelico F, Mancone C. Overexpression of the Vitronectin V10 Subunit in Patients with Nonalcoholic Steatohepatitis: Implications for Noninvasive Diagnosis of NASH. Int J Mol Sci. 2018;19:603.
14. Lo Sciuto A, Martorana AM, Fernández-Piñar R, Mancone C, Polissi A, Imperi F. Pseudomonas aeruginosa LptE is crucial for LptD assembly, cell envelope integrity, antibiotic resistance and virulence. Virulence. 2018;9:1718-1733.
15. Orecchini E, Doria M, Antonioni A, Galardi S, Ciafrè SA, Frassinelli L, Mancone C, Montaldo C, Tripodi M, Michienzi A. ADAR1 restricts LINE-1 retrotransposition. Nucleic Acids Res. 2017;45:155-168.
16. Cicchillitti L, Manni I, Mancone C, Regazzo G, Spagnuolo M, Alonzi T, Carlomosti F, Dell'Anna ML, Dell'Omo G, Picardo M, Ciana P, Capogrossi MC, Tripodi M, Magenta A, Rizzo MG, Gurtner A, Piaggio G. The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation. Oncotarget. 2017;8:2628-2646.
17. Conigliaro A, Costa V, Amato R, Mancone C. Data on the effects of low iron diet on serum lipid profile in HCV transgenic mouse model. Data Brief. 2017;12:22-25.
18. Costanzo G, Giorgi A, Scipioni A, Timperio AM, Mancone C, Tripodi M, Kapralov M, Krasavin E, Kruse H, Sponer J, Sponer JE, Ranc V, Otyepka M, Pino S, Di Mauro E. Non-Enzymatic Oligomerization of 3',5' Cyclic CMP Induced by Proton- and UV-Irradiation Hints at a Non-Fastidious Origin of RNA. Chembiochem. 2017;18:1535-1543.
19. Mancone C, Grimaldi A, Refolo G, Abbate I, Rozera G, Benelli D, Fimia GM, Barnaba V, Tripodi M, Piacentini M, Ciccosanti F. Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes. Proteome Sci. 2017;15:18.
20. Baiocchini A, Montaldo C, Conigliaro A, Grimaldi A, Correani V, Mura F, Ciccosanti F, Rotiroti N, Brenna A, Montalbano M, D'Offizi G, Capobianchi MR, Alessandro R, Piacentini M, Schininà ME, Maras B, Del Nonno F, Tripodi M, Mancone C. Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution. PLoS One. 2016;11:e0151736.
21. Lo Dico A, Costa V, Martelli C, Diceglie C, Rajata F, Rizzo A, Mancone C, Tripodi M, Ottobrini L, Alessandro R, Conigliaro A. MiR675-5p Acts on HIF-1 to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma. Theranostics. 2016;6:1105-18.
22. Santangelo L, Giurato G, Cicchini C, Montaldo C, Mancone C, Tarallo R, Battistelli C, Alonzi T, Weisz A, Tripodi M. The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Cell Rep. 2016;17:799-808.
23. Cicchini C, Amicone L, Alonzi T, Marchetti A, Mancone C, Tripodi M. Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte. Liver Int. 2015;35:302-10.
24. Pinzaglia M, Montaldo C, Polinari D, Simone M, La Teana A, Tripodi M, Mancone C, Londei P, Benelli D. eIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins. BMC Cancer. 2015;15:131.
25. Conigliaro A, Costa V, Lo Dico A, Saieva L, Buccheri S, Dieli F, Manno M, Raccosta S, Mancone C, Tripodi M, De Leo G, Alessandro R. CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA. Mol Cancer. 2015;14:155.
26. Paroli M, Bellati F, Videtta M, Focaccetti C, Mancone C, Donato T, Antonilli M, Perniola G, Accapezzato D, Napoletano C, Nuti M, Bartolazzi A, Panici PB, Tripodi M, Palombo F, Barnaba V. Discovery of chemotherapy-associated ovarian cancer antigens by interrogating memory T cells. Int J Cancer. 2014;134:1823-34.
27. Montaldo C, Mancone C, Conigliaro A, Cozzolino AM, de Nonno V, Tripodi M. SILAC labeling coupled to shotgun proteomics analysis of membrane proteins of liver stem/hepatocyte allows to candidate the inhibition of TGF-beta pathway as causal to differentiation. Proteome Sci. 2014;12:15.
28. Montaldo C, Mattei S, Baiocchini A, Rotiroti N, Del Nonno F, Pucillo LP, Cozzolino AM, Battistelli C, Amicone L, Ippolito G, van Noort V, Conigliaro A, Alonzi T, Tripodi M, Mancone C. Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload. Proteomics. 2014;14:1107-15.
29. Cozzolino A.M., Alonzi T., Santangelo L., Mancone C., Conti B., Steindler C., Musone M., Cicchini C., Tripodi M., Marchetti A. TGF overrides HNF4 tumor suppressing activity through GSK3 inactivation: implication for hepatocellular carcinoma gene therapy. J Hepatol. 2013;58:65-72.
30. Mancone C., Ciccosanti F., Montaldo C., Perdomo A.B., Piacentini M., Alonzi T., Fimia G.M., Tripodi M. Applying proteomic technology to clinical virology . Clin Microbiol Infec. 2013;19:23-8.
31. Conigliaro A., Amicone L., Costa V., De Santis Puzzona M., Mancone C., Sacchetti B., Cicchini C., Garibaldi F., Brenner D.A., Kisseleva T., Bianco P. and Tripodi M. Evidence for a common progenitor of epithelial and mesenchymal components of the liver . Cell Death Differ. 2013;20:1116-23.
32. Mancone C., Montaldo C., Santangelo L., Di Giacomo C., Costa V., Amicone L., Ippolito G., Pucillo L.P., Alonzi T., Tripodi M.: Ferritin heavy chain is the host factor responsible for HCV-induced inhibition of apoB-100 production and is required for efficient viral infection. J Proteome Res. 2012;11:2786-97.
33. Mancone C., Steindler C., Santangelo L., Simonte G., , Vlassi C., Longo M.A., D Offizi G., Di Giacomo C., Pucillo L.P., Amicone L., Tripodi M and Alonzi T.: Hepatitis C Virus production requires apolipoprotein A-I and affects its association to the nascent low-density lipoproteins . Gut 2011;60:378-86.
34. Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, Tripodi M. The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4 . Hepatology. 2011;53:2063-74.
35. Mancone C., Conti B, Amicone L, Bordoni V, Cicchini C, Calvo L, Perdomo AB, Fimia GM, Tripodi M, Alonzi T.: Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes . J Hepatol. 2010;52:234-243.
36. Notari S., Mancone C., Sergi M., Bevilacqua N., Tempestilli M., Urso R., Lauria F.N, Pucillo L.P., Tripodi M. and Ascenzi P.: Determination of anti-tuberculosis drug concentration in human plasma by MALDI-TOF/TOF . IUMBlife 2010;62:387-93.
37. Benelli D., Marzi S., Mancone C., Alonzi T., La Teana A. and Londei P.: Function and ribosomal localization of aIF6, a translational regulator shared by archaea and eukarya. . Nucleic Acids Res. 2009;37:256-67.
38. Imperi F., Ciccosanti F., Basulto A., Tiburzi F., Mancone C., Alonzi T., Ascenzi P., Piacentini M., Visca P., Fimia G.M.: Periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen . Proteomics, 2009;9:1901-15.
39. Giorgi A, Di Francesco L, Principe S, Mignogna G, Sennels L, Mancone C, Alonzi T, Sbriccoli M, De Pascalis A, Rappsilber J, Cardone F, Pocchiari M, Maras B and Schininà ME.: Proteomic profiling of amyloid aggregates isolated from the brain of hamsters experimentally infected with scrapie . Proteomics, 2009;9:3802-3814.
40. Rossi M.N., Carbone M., Mostocotto C., Mancone C., Tripodi M., Maione R. and Amati P.: Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial dna integrity . J Biol Chem. 2009;284:31616-24.
41. Nolan T., Cecere G., Mancone C., Alonzi T., Tripodi M., Catalanotto C. and Cogoni C.: The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A . Nucleic Acids Research, 2008;36:532-8.
42. Alonzi T., Mancone C., Amicone L. and Tripodi M.: Elucidation of lipoproteins particles structure by proteomic analysis: present knowledge and future perspectives . Expert Rev Proteomics. 2008;5:91-104.
43. Notari S., Mancone C., Alonzi T., Tripodi M., Narciso P., and Ascenzi P.: Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF . J Chromatogr B Analyt Technol Biomed Life Sci. 2008;863:249-257.
44. Marchetti A, Colletti M, Cozzolino AM, Steindler C, Lunadei M, Mancone C, Tripodi M.: ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK3beta-mediated Snail protein stabilization . Cell Signal. 2008;20:2113-8.
45. Bonente G., Passarini G., Mancone C., Buia M.C., Tripodi M., Bassi R. and Caffarri S.: The occurrence of the PsbS gene product in Chlamydomonas reinhardtii and other photosynthetic organisms and its correlation with energy quenching . Photochemistry and Photobiology 2008;84: 1359-1370.
46. Mancone C., Amicone L., Fimia GM. Bravo E., Piacentini M., Tripodi M. and Alonzi T.: Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF . Proteomics, 2007;7: 143-154.
47. Napolitano M., Giuliani A., Alonzi T., Mancone C., D offizi G., Tripodi M. and Bravo E.. Very Low Density Lipoprotein and Low Density Lipoprotein isolated from HCV patients induce altered cellular lipid metabolism . Journal of Medical Virology 2007;79:254 258.
48. Mancone C., Notari S., Tripodi M., Narciso P., Fasano M. and Ascenzi P. Determination of anti-HIV drug concentration in human plasma by MALDI-TOF/TOF . J Chromatogr B Analyt Technol Biomed Life Sci. 2006;833:109-16.
49. Campostrini N., Marimpietri D., Totolo A., Mancone C., Fimia G.M., Ponzoni M. and Rigetti P.G.: Proteomic analysis of anti-angiogenic effects by a combined treatment with vinblastine and rapamycin in an endothelial cell line . Proteomics, 2006;6:4420 4431.
50. Schininà M.E., Mancone C., Principe S., Cardone F., Maras B. and Pocchiari M.: Prion protein allotype profiling by mass spectrometry . Pure Applied Chemestry 2003;75:317-323.