Ritratto di Paola.Pietrangeli@uniroma1.it

Previo appuntamento (concordare con il docente utilizzando la mail istituzionale); Dipartimento Scienze Biochimiche “A. Rossi Fanelli”, II piano, stanza 215.

Curriculum scientifico:

1989 Laurea in Scienze Biologiche 110/110 e lode presso l Università degli Studi di Roma La Sapienza
1989-1992 Dottorato di Ricerca in Biochimica (conseguimento titolo 21/5/1993)
1993-1995 Borsa di Studio CNR Progetto Finalizzato Chimica Fine
1996-1997 Borsa di studio Post-dottorato
Dal 1998 Ricercatore (SSD BIO 10) in servizio presso il Dipartimento di Scienze Biochimiche A. Rossi Fanelli Università di Roma Sapienza

ATTIVITA DIDATTICA
Dal 2001 al 2011 supplenze relative ai seguenti insegnamenti: - Metodologie Biochimiche - Corso di laurea in CTF - Enzimologia - Corso di laurea in CTF - Biochimica Clinica e Biologia Molecolare Clinica - Corso di Laurea Triennale in Informazione Scientifica sul Farmaco - Biochimica Clinica e Biologia Molecolare Clinica - Corso di Laurea Triennale in Tossicologia dell Ambiente - Biochimica Applicata - Corso di Laurea Triennale in Tossicologia dell Ambiente - Biochimica Clinica - Corso di Laurea Triennale in Chimica e Tecnologia Farmaceutiche
Anno accademico 2011-2012 - Biochimica I Corso di Laurea Triennale in Scienze Farmaceutiche Applicate - Biochimica II - Corso di Laurea Triennale in Scienze Farmaceutiche Applicate
Dal 2012 ad oggi - Biochimica (9 CFU) per il Corso di Laurea Triennale in Scienze Farmaceutiche Applicate

ATTIVITA SCIENTIFICA
Studio della struttura e funzione delle amino ossidasi, classe di enzimi rame e FAD-dipendenti deputati alla deaminazione ossidativa delle amine biogene:
a) studi cinetici dell attività catalitica delle forme enzimatiche contenenti rame purificate da fonti animali e vegetali e correlazione con le specifiche caratteristiche strutturali;
b) ruolo delle forme enzimatiche intracellulari nella modulazione dello stato ossido riduttivo della cellula;
c) Studio del livello dell enzima del siero in varie condizioni patologiche umane;
d) Utilizzo delle amino ossidasi di origine vegetale ad attività anti-istaminasica nella modulazione dei processi infiammatori.

ELENCO PUBBLICAZIONI

1)Hemoglobin-dependent inhibitory effect of hemolyzed human erythrocytes on bovine plasma amine oxidase activity.
L. Marcocci, P. Pietrangeli, O. Befani, I. Mavelli and B. Mondovì.
It. J. Biochem. 40: 38A-40A (1991), Rome, Italy.

2)Production of hydrogen peroxide by human red blood cells exposed to anthracycline antibiotic daunomycin.
L. Marcocci, P. Pietrangeli, I. Mavelli, G. Rotilio.
It. J. Biochem. 40: 283A-285A (1991), Rome, Italy.

3)Inhibition of bovine serum amine oxidase activity by hemoglobin.
L. Marcocci, P. Pietrangeli, O. Befani, I. Mavelli, B. Mondovì.
Life Chemistry Reports, 9: 171-177 (1991), Singapore.

4)Plasma membrane as a site of redox activation of daunomycin in intact human erythrocytes: quantitative evaluation of the hydrogen peroxide produced by the membrane with respect to the cytosol.
L. Marcocci, P. Pietrangeli, I. Mavelli, G. Rotilio.
Biochem. Pharmacol. 44: 1535-1542 (1992), Oxford.

5)Modulation of the cell response to hyperthermia by membrane perturbating agents.
S. Meschini, A. Calcabrini, P. Matarrese, L. Marcocci, P. Pietrangeli, A. Candiloro, W. Malorni.
Molecular Oncology and Clinical Applications (A. Cittadini, R. Baserga, H. Pinedo, P. Corda, T. Galeotti eds.) 285-290 (1993), Swizterland.

6)Effects of incubation with liposomes at different temperatures on cultured melanoma cells (M14).
G. Arancia, A. Calcabrini, P. Matarrese, L. Marcocci, P. Pietrangeli, B. Mondovì.
Int. J. Hyperthermia 10:101-114 (1994), London.

7)Enhancement of daunomycin toxicity by the differentiation inducer hexamethylene bisacetamide in erythroleukemia cells.
P. Pietrangeli, C. Steinkühler, L. Marcocci, J.Z. Pedersen, B. Mondovì, I. Mavelli.
Biochim. Biophys. Acta, 1224:89-98 (1994), Amsterdam.

8)Hyperthermia-induced biochemical and ultrastructural modifications in cultured cells.
E. Agostinelli, G. Arancia, A. Calcabrini, P. Matarrese, B. Mondovì, P. Pietrangeli.
Experimental Oncology, 17:269-276 (1995), Kiev.

9)Extended substrate specificity of serum amine oxidase: possible involvement in protein posttranslational modification.
X.T. Wang, P. Pietrangeli, M.A. Mateescu, B. Mondovì.
Biochem. Biophys. Res. Commun., 223:91-97 (1996), New York.

10)A possible role of bovine serum amine oxidase in oxidation of some lysine terminal proteins.
P. Pietrangeli, X.T. Wang, M.A. Mateescu and B. Mondovì.
It. J. Biochem., 46:146 (1997), Milano.

11)Possible oxidation of free amino groups of macromolecules of bovine serum amine oxidase.
P. Pietrangeli, X.T. Wang, M.A. Mateescu and B. Mondovì.
It. J. Biochem., 46:113-117 (1997).

12)New aspect on the physiological role of copper-amine oxidases.
B. Mondovì, X.T. Wang, P. Pietrangeli, R. Wang, R. Nadeau, M.A. Mateescu.
Current Topics in Medicinal Chemistry, 2:31-43 (1997).

13)Polyol pathway activation and glutathione redox status in NIDDM patients.
M.C. Bravi, P. Pietrangeli, O. Laurenti, S. Basili, M. Cassone-Faldetta, C. Ferri, G. De Mattia.
Metabolism, 46:1194-1198 (1997), New York.

14)Inhibitory effect of 1,3,5-triphenyl-4,5-dihydro-(1H)-pyrazole derivatives on amine oxidases activity.
F. Manna, F. Chimenti, A. Bolasco, B. Bizzarri, O. Befani, P. Pietrangeli, B. Mondovì, P. Turini.
J. Enzyme Inhibition, 13:207-216 (1998), Amsterdam.

15)Characterization of the hemoglobin-mediated inhibition of the enzymatic activity of bovine serum amine oxidase.
P. Pietrangeli, L. Marcocci, L. Morpurgo, O. Befani, X.T. Wang, B. Mondovì.
It. J. Biochem. 47:7-12 (1998).

16)Protection against apoptosis by monoamine oxidase A inhibitors.
A. Malorni, A.M. Giammarioli, P. Matarrese, P. Pietrangeli, E. Agostinelli, A. Ciaccio, E. Grassilli, B. Mondovi'.
FEBS Letters 426:155-159 (1998), Amsterdam.

17)Modulation of bovine serum amine oxidase activity by hydrogen peroxide.
P. Pietrangeli, S. Nocera, P. Fattibene, X.T. Wang, B. Mondovi', L. Morpurgo.
Biochem. Biophys. Res. Commun. 267:174-178 (2000), San Diego.

18)In vivo cross-linking of nm23/nucleoside diphosphate kinase to the PDGF-A gene promoter.
L. Cervoni, P. Pietrangeli, S. Chichiarelli, F. Altieri, L. Egistelli, C. Turano, I. Lascu, A. Giartosio.
Molecular Biology Reports. 30:33-40 (2003), Boston.

19)Some new functions of amine oxidases
B. Mondovì, P. Pietrangeli, L. Morpurgo, E. Masini, R. Federico, M. A. Mateescu, O. Befani, E. Agostinelli
Inflammopharmacology. 11:155-163 (2003), The Netherlands

20)New perspectives on the role of amine oxidases in physiopathology.
S. Nocera, L. Marcocci, P. Pietrangeli, B. Mondovi'
Amino Acids 24:13-17 (2003), Austria

21)Is the catalytic mechanism of bacteria, plant, and mammal copper-TPQ amine oxidases identical?
P. Pietrangeli, S. Nocera, B. Mondovì, L. Morpurgo.
Biochim. Biophys. Acta. 1647:152-156 (2003), Amsterdam

22)Protective effects of a plant histaminase in myocardial ischaemia and reperfusion injury in vivo.
E. Masini, S. Pierpaoli, C. Marzocca, P.F. Mannaioni, P. Pietrangeli, M.A. Mateescu, M. Zelli, R. Federico, B. Mondovi.
Biochem. Biophys. Res. Commun. 309:432-439 (2003), (New York)

23)L-Deprenyl as an inhibitor of menadione-induced permeability transition in liver mitochondria.
U. De Marchi, P. Pietrangeli, L. Marcocci, B. Mondovi , A. Toninello.
Biochem. Pharmacol. 66: 1749-1754 (2003).

24)Inactivation of copper-containing amine oxidases by turnover products.
P. Pietrangeli, S. Nocera, R. Federico, B. Mondovi , L. Morpurgo.
Eur. J. Biochem. 271: 146-152 (2004).

25)Amine oxidases and tumors.
P. Pietrangeli, B. Mondovì.
NeuroToxicology 25: 317-324 (2004).

26)On the biochemical basis of tumor damage by hyperthermia
P. Pietrangeli, B. Mondovì.
In: Locoregional Radiofrequency-Perfusional and Whole-Body Hyperthermia in Cancer Treatment: New Clinical Aspects. Baronzio G.F. ed., pp. 1-9 (2004).

27)Biogenic amines and apoptosis.
A.Toninello, M. Salvi, P. Pietrangeli, B. Mondovì.
Amino Acids 26: 339-343 (2004), Austria.

28)Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors.
C. Lamanna, M.S. Sinicropi, P. Pietrangeli, F. Corbo, C. Franchini, B. Mondovì, M.G. Perrone, A. Scilimati
ARKIVOC (V) 118-130 (2004)

29)Amine oxidases in apoptosis and cancer.
A. Toninello, P. Pietrangeli, U. De Marchi, M. Salvi, B. Mondovì.
Biochim Biophys Acta: Review on Cancer 1765:1-13 (2006)

30)Beneficial effects of a plant histaminase in a rat model splanchnic artery occlusion and reperfusion.
E. Masini, S. Cuzzocrea, D. Bani, E. Mazzon, C. Mujà, R. Mastroianni, F. Fabrizi, P. Pietrangeli, L. Marcocci, B. Mondovì, P.F. Mannaioni, R. Federico.
Shock 27: 409-415 (2007)

31)Substrate specificity of copper-containing plant amine oxidases.
P. Pietrangeli , R. Federico, B. Mondovì , L. Morpurgo
J. Inorg. Biochem. 101: 997-1004 (2007)

32)Catalase takes part in rat liver mitochondria oxidative stress defence
M. Salvi, V. Battaglia, A.M. Brunati, N. La Rocca, E. Tibaldi, P. Pietrangeli, L Marcocci, B. Mondovì, C.A. Rossi, A. Toninello.
J Biol. Chem. 282: 24407- 24415 (2007)

33)Soluble amine oxidases from mammals.
P. Pietrangeli , L. Morpurgo, B. Mondovì , ML Di Paolo, A. Rigo
In: Copper amine oxidases: structures, catalytic mechanisms and role in pathophysiology.
G. Floris & B. Mondovì eds. 51 68 (2009)

34)Some possible pharmacological application of copper amine oxidase
P. Pietrangeli, E. Masini, L. Raimondi, R. Federico, B. Mondovì.
In: Biologically Active Amines and Related Enzymes: Biochemical, Physiological and Clinical Aspects Research Signpost/Transworld Research Network
A.Toninello ed. 177-198 (2009) ISBN:978-81-7895-433.2

35) A New Piece of the Shigella Pathogenicity Puzzle: Spermidine Accumulation by Silencing of the speG Gene
Marialuisa Barbagallo, Maria Letizia Di Martino, Lucia Marcocci, Paola Pietrangeli, Elena De Carolis, Mariassunta Casalino, Bianca Colonna, Gianni Prosseda.
PLoS One. 2011;6(11):e27226. Epub 2011 Nov 10.

36)Lathyrus cicera copper amine oxidase reactions with tryptamine.
P. Pietrangeli, A. Bellelli, P. Fattibene, B. Mondovì, L. Morpurgo
J. Inorg. Biochem. 2012 Jan 12;109:33-39.

37)Molecular and functional profiling of the polyamine content in enteroinvasive E. coli: looking into the gap between commensal E. coli and harmful Shigella.
Rosaria Campilongo; Maria Letizia Di Martino; Lucia Marcocci; Paola Pietrangeli; Adriano Leuzzi; Mariassunta Casalino; Mauro Nicoletti; Gioacchino Micheli; Bianca Colonna; Gianni Prosseda
PLoS One. 2014 Sep 5;9(9):e106589. doi: 10.1371/journal.pone.0106589. eCollection 2014.

38)Carboxymethyl-starch/alginate microspheres containing diamine oxidase for intestinal targeting.
Lindsay Blemur, Tien Canh Le, Lucia Marcocci, Paola Pietrangeli, Mircea Alexandru Mateescu.
Biotechnol Appl Biochem. 2015 Mar 16. doi: 10.1002/bab.1369. [Epub ahead of print]

39) Multifactor regulation of the MdtJI polyamine transporter in Shigella.
Adriano Leuzzi, Maria Letizia Di Martino, Rosaria Campilongo, Maurizio Falconi, Marialuisa Barbagallo, Lucia Marcocci, Paola Pietrangeli, Mariassunta Casalino, Milena Grossi, Gioacchino Micheli, Bianca Colonna, Gianni Prosseda.
PLoS One. 2015 Aug 27;10(8):e0136744. doi: 10.1371/journal.pone.0136744. eCollection 2015

40) Diamine oxidase from white pea (Lathyrus sativus) combined with catalase protects the human intestinal Caco-2 cell line from histamine damage.
Catherine Jumarie, Marilyne Seide, Lucia Marcocci, Paola Pietrangeli, Mircea Alexandru Mateescu.
Appl. Biochem. Biotechnol. 2017 Jan 20. doi: 10.1007/s12010-016-2390-3. [Epub ahead of print]

41) Zymographic approach to determine the intrinsic enzyme specific activity of diamine oxidase in presence of interfering enzymes.
Ahmadifar S, Le TC, Marcocci L, Pietrangeli P, Mateescu MA.
Anal Chim Acta. 2017 Jul 4;975:78-85. doi: 10.1016/j.aca.2017.04.006. Epub 2017 Apr

42) Zymographic Determination of Intrinsic Specific Activity of Oxidases in the Presence of Interfering Proteins.
Le TC, Mateescu MA, Ahmadifar S, Marcocci L, Pietrangeli P.
Methods Mol Biol. 2018;1853:207-221. doi: 10.1007/978-1-4939-8745-0_24.

43) Stability of Vegetal Diamine Oxidase in Simulated Intestinal Media: Protective Role of Cholic Acids.
Neree AT, Pietrangeli P, Szabo PI, Mateescu MA, Marcocci L.
J Agric Food Chem. 2018 Nov 20. doi: 10.1021/acs.jafc.8b04005. [Epub ahead of print]

44) Type E Botulinum Neurotoxin-Producing Clostridium butyricum Strains Are Aerotolerant during Vegetative Growth.
Camerini S, Marcocci L, Picarazzi L, Iorio E, Ruspantini I, Pietrangeli P, Crescenzi M, Franciosa G.
mSystems. 2019 Apr 30;4(2):e00299-18. doi: 10.1128/mSystems.00299-18. eCollection 2019 Mar-Apr.

45) Lathyrus sativus diamine oxidase counteracts histamine-induced cell proliferation, migration and pro-angiogenic mediators release in human colon adenocarcinoma cell line Caco-2.
Pietrangeli P, Seguella L, Annunziata G, Casano F, Capuano R, Pesce M, De Conno B, Gigli S, Sarnelli G, Pesce M, Mateescu MA, Esposito G, Marcocci L.
Phytother Res. 2019 Jul;33(7):1878-1887. doi: 10.1002/ptr.6378. Epub 2019 May 29.

46) Copper containing amine oxidase purified from Lathyrus sativus as a modulator of human neutrophil functions.
Pietrangeli P, Capuozzo E, Mateescu MA, Marcocci L.
Int J Mol Med. 2020 May;45(5):1583-1590. doi: 10.3892/ijmm.2020.4535. Epub 2020 Mar 11.

47) Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles.
Neree AT, Soret R, Marcocci L, Pietrangeli P, Pilon N, Mateescu MA.
Sci Rep. 2020 Dec 9;10(1):21563. doi: 10.1038/s41598-020-78134-3.

48) Lathyrus sativus diamine oxidase reduces Clostridium difficile toxin A-induced toxicity in Caco-2 cells by rescuing RhoA-GTPase and inhibiting pp38-MAPK/NF- B/HIF-1 activation.
Pietrangeli P, Corpetti C, Seguella L, Del Re A, Pesce M, Vincenzi M, Lori C, Annunziata G, Mateescu MA, Sarnelli G, Esposito G, Marcocci L.
Phytother Res. 2021 Jan;35(1):415-423. doi: 10.1002/ptr.6814. Epub 2020 Sep 10.

49) Faster and sensitive zymographic detection of oxidases generating hydrogen peroxide. The case of diamine oxidase.
Chomdom Kounga P, Neree AT, Pietrangeli P, Marcocci M, Mateescu MA.
Anal Biochem. 2022 Jul 1;648:114676. doi: 10.1016/j.ab.2022.114676. Epub 2022 Mar 29.