Catalogo dei Corsi di studio

Contact information
Department of Biochemical Sciences
P.le Aldo Moro 5 00185 Roma
E-mail elena.forte@uniroma1.it

Present position
Associate professor, Sapienza University of Rome, Department of Biochemical Sciences

Research interests
Structure-function, molecular evolution and control of enzymes involved in the oxygen, nitric oxide and sulphide metabolism. The research focuses primarily on the role of these gaseous molecules, and associated reactive species, in mitochondrial physiology or pathology and in the microbial response to oxidative and nitrosative stress.

Education
PhD in Biochemistry, Sapienza University of Rome
Specialization in Biotechnology, Sapienza University of Rome
Laurea with honours in Biology, Sapienza University of Rome

Previous position and visiting
2006-2015 Researcher, Sapienza University of Rome, Department of Biochemical Sciences
2001-2005 Research Fellowship Department of Biochemistry, University of Rome La Sapienza
2003 visiting scientist, University of Cambridge, UK, Department of Biochemistry
2000 Fellowship Department of Chemistry, University of Rome La Sapienza
1999 Fellowship Department of Biochemistry, University of Rome La Sapienza .
1997-1998 Pasteur Institute-Cenci-Bolognetti Foundation Research Fellowship.
1996 IFO fellowship, Istituto Superiore di Sanità, Department of Cellular Biology
1994-1995 CNR Research fellowship, Institute of Biomedical Technologies
1992-1993 Department of Experimental Medicine, University of Rome Tor Vergata

Teaching
-Chemistry and Introduction to Biochemistry, degree course in Medicine and Surgery, Faculty of Medicine and Psycology Sapienza University of Rome
-Biochemistry, Sapienza University of Rome degree courses in
Nursing, Physiotherapy Occupational therap,y Techniques in Orthopaedic,Podiatry, Psychiatric rehabilitation technique

-Board member of the PhD program in Biochemistry Sapienza University of Rome
Member of Italian Group of Bioenergetics and of the Executive Committee the Italian Society of Biochemistry and Molecular Biology
Member of the editorial board of : -Journal of Chemistry, - Antioxidants
Referee for BBA, Nitric Oxide, Parasite, Archives of Biochemistry and Biophysics, Comparative Biochemistry and Physiology

Recent publications

1. Forte E, Borisov VB, Vicente JB, Giuffrè A. Cytochrome bd and gaseous ligands in bacterial physiology Advances in Microbial Physiology 2017;71:171-234
2. Parente MR, Forte E, Falabella M, Boneca IG, Teixeira M, Giuffrè A, Saraiva LM. Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum. Sci Rep. 2017 30;7(1):9909
3. Forte E, Borisov VB, Falabella M, Colaço HG, Tinajero-Trejo M, Poole RK, Vicente JB, Sarti P, Giuffrè A. The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth Sci Rep (2016) 31;6:23788.
4. Forte E, Giuffrè A. How bacteria breathe in hydrogen sulfide-rich environments Biochemist (2016) 38:8-11
5. Vicente JB, Malagrinò F, Arese M, Forte E, Sarti P, Giuffrè A. Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine ß-synthase Biochim Biophys Acta (2016) 1857: 1127-1138
6. Martire S, Fuso A, Mosca L, Forte E, Correani V, Fontana M, Scarpa S, Maras B,D Erme M. Bioenergetic impairment in animal and cellular models of Alzheimer's disease: PARP-1 inhibition rescues metabolic dysfunctions Journal of Alzheimer's Disease (2016) 54(1): 307-324
7. Falabella M*, Forte E*, Magnifico MC, Santini P, Arese M, Giuffrè A, Radi K, Chessa L, Coarelli G, Buscarinu MC, Mechelli R, Salvetti M, Sarti P. Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber's Hereditary Optic Neuropathy Cells Oxid Med Cell Longev. (2016); 2016:3187560
8. Mastronicola D, Falabella M, Forte E, Testa F, Sarti P, Giuffrè A. Antioxidant defence systems in the protozoan pathogen Giardia intestinalis. Mol Biochem Parasitol. (2016) 1-2:56-66
9. Borisov, V.B. , Forte E , Siletsky, S.A, Arese, M., Davletshin, A.I., Sarti, P., Giuffrè, A. Cytochrome bd Protects Bacteria against Oxidative and Nitrosative Stress: A Potential Target for Next-Generation Antimicrobial Agents.Biochemistry (Moscow) (2015), 5: 565-575
10. Angiulli G, Lantella A, Forte E, Angelucci F, Colotti G, Ilari A, Malatesta F. Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase.Biochim Biophys Acta.( 2015) 9:1891-7.
11. Borisov VB*, Forte E*, Siletsky SA, Sarti P, Giuffrè A. Cytochrome bd from Escherichia coli catalyzes peroxynitrite decomposition Biochim Biophys Acta. (2015) Feb;1847(2):182-8