Catalogo dei Corsi di studio

ADELE ROMANO

Current Position (since July 2022): Associate Professor of Pharmacology, Sapienza University of Rome

March 2023 National Scientific Qualification as Full Professor in Pharmacology (Abilitazione Scientifica Nazionale per Professore di I fascia SSD BIO/14 SSC 05/G1)

WORK ADDRESS:
Dept. of Physiology and Pharmacology V. Erspamer , Sapienza University of Rome, Italy
Piazzale Aldo Moro, 5 00185 Rome, Italy
Tel: +39 06 4991 2505
Fax: +39 06 4991 2480
Email address: adele.romano@uniroma1.it

EDUCATION
-2007: Master in Pharmacy 110/110, School of Pharmacy, University of Naples, Federico II , Italy
-2007: Board Certified Pharmacist University of Naples, Federico II , Italy
-2011: PhD in Toxicology, Sapienza University of Rome, Italy
-2007-2010: Pre-doctorate training (3-year-training on neuropsychopharmacology using different animal models of eating disorders, obesity and Alzheimer s disease). Dept. of Physiology and Pharmacology V. Erspamer , Sapienza University of Rome Italy, School of Pharmacy and Medicine.
-2009: Pre-doctorate training. Short-term training as visiting student at the Toxicology Unit of the University of Leicester, UK

OTHER QUALIFICATIONS
2005 Certificate in English knowledge, University of Cambridge, UK
2011 Felasa Licence cat B for experimental procedures on laboratory animals, EBRI Foundation

2012 Licence for Surgery course on laboratory rats, Institute of Food Nutrition and Health, Physiology and Behaviour Laboratory, ETH Zurich, Switzerland
2022 Certificate of expert in innovative didactic activity (Percorso Formativo biennale QuID per docent Sapienza)

ACADEMIC HISTORY
Feb 2011-July 2012 Post-Doc at the Department of Biomedical Sciences and Public Health University Politecnica delle Marche, Ancona Italy. School of Medicine and Surgery
Feb 2012-July 2012 Guest Researcher at the Institute of Veterinary Physiology University of Zurich, Switzerland
Dec 2012- June 2019: 7-year Post-Doc (Assegnista di Ricerca) at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
March 2017: National Scientific Qualification as Associate Professor in Pharmacology (Abilitazione Scientifica Nazionale per Professore II fascia SSD BIO/14 SSC 05/G1)
July 2019-May 2022: Assistant Professor of Pharmacology (Ricercatore a tempo determinato tipologia B) at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
July 2022-present: Associate Professor of Pharmacology at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy

AWARDS AND HONORS
2010 Travel award of the Italian Society of Pharmacology, to attend the 16th World Congress of Basic and Clinical Pharmacology, Copenhagen
2010 Travel award of GDRE-691, to participate to the Summer School of GDRE-691: Early Programming of Adult Modern Diseases , Lille France
2012 Travel award of the European Behavioural Pharmacology Society (EBPS), to attend (as invited speaker) the Workshop on Eating Behaviour and Obesity , September, 2012 Lecce, Italy
2012 6- months scholarship (1000 Euro) of the Italian Society of Pharmacology for selected young researchers to attend international laboratories
2013 Travel award (1.000 $) of the Society for the Study of Ingestive Behavior (SSIB), to attend (as invited speaker) the 21st Annual Meeting of the Society for the Study of Ingestive Behavior. New Orleans, LA
2013 Best poster Award (500 Euro) of the Italian Society of Pharmacology during the national meeting of the Italian Society of Pharmacology, Torino, Italy
2015 Travel award (500 Euro) of the Italian Society for Neuroscience (SINS) to attend (as invited speaker) the 16th Congress for the SINS, Cagliari, Italy
2017 Travel award (500 Euro) of the Italian Society for Neuroscience (SINS) to attend (as invited speaker) the 17th Congress for the SINS, Ischia, Italy
2017 Farmaindustria Award (5.000 Euro) of the Italian Society of Pharmacology (SIF) for young researchers for their scientific achievements
2017 Best poster Award (500 Euro) of the Italian Society of Pharmacology during the national meeting of the Italian Society of Pharmacology, Rimini, Italy
2017 Alberigo Benedicenti Award (2.000 Euro) of the University of Florence, Italy to Young Pharmacology Experts ( Cultori della materia ), who have demonstrated the best scientific activity in the field of pharmacology and toxicology studies during the years 2014-2016.
2018 Winner of a Teaching assignments for staff Mobility within the framework of the Erasmus Swiss-European Mobility Programme 2017/2018 (amount credited 1.350 CHF).
2018 Certificate of merit for being classified among the 10 best project proposals received (out of 400 proposals) for the L'Oréal Italy-UNESCO For Women in Science 2017/2018 Edition.

RESEARCH GRANTS OBTAINED AS PRINCIPAL INVESTIGATOR
2014: Intramural research grant, Sapienza University of Rome 3.000
Title of the research: The role of the area postrema in the anorectic effects of oleoylethanolamide: behavioral and neuronal phenotyping.
2015: Intramural research grant, Sapienza University of Rome 2.000
Title of the research: Effetti dell oleoiletanolamide in un modello di binge eating: studio del sistema ossitocinergico centrale.
2016: Intramural research grant, Sapienza University of Rome 2.000
Title of the research: Effetto del trattamento cronico con oleoiletanolammide sul comportamento alimentare e sul microbiota intestinale in un modello animale di obesita indotta dalla dieta
2017: Intramural research grant, Sapienza University of Rome 2.250
Title of the research: Effects of Oleoylethanolamide on mesolimbic dopaminergic transmission in an animal model of binge eating
2018: Intramural research grant, Sapienza University of Rome 2.000
Title of the research: Effetti dell'oleoiletanolamide sull'attivazione di aree centrali e sul sitema di neurotrasmissione monoaminergico in un modello sperimentale di "Binge Eating Disorder"
2021: Progetti di Rilevante Interesse Nazionale (PRIN) Italian National Research Grant
175.157
Title of the research: Regulation of autophagy by N-acylethanolamines as a promising approach for the treatment of inflammatory-based diseases: from neurodegeneration to metabolic disorders.
2022: Banca d Italia 30.000
Title of the research: Regulation of autophagy by N-acylethanolamines as a promising approach for the treatment of inflammatory-based diseases: from neurodegeneration to metabolic disorders
2022: Intramural research grant, Sapienza University of Rome, 3.000
Title of the research: Antinflammatory and neuroprotective effects of oleoylethanolamide in a rat model of diet-induced obesity.
2022: Progetti di Rilevante Interesse Nazionale (PRIN) Italian National Research Grant 127.185
Title of the research: Modulation of the endocannabinoid system as a possible pharmacological approach for the treatment of pathological consequences of social isolation: beyond cannabinoid receptors
2022: Progetti di Rilevante Interesse Nazionale (PRIN) PNRR Italian National Research Grant 60.069
Title of the research: Deciphering the role of the cytokine eNAMPT in controlling neuroinflammation in Parkinson Diseases
2023: Intramural research grant, Sapienza University of Rome, 24.000.
Title of the research: Targeting autophagy in hypothalamic neuropeptidergic neurons as a possible pharmacological approach to regulate food intake and energy balance

RESEARCH GRANTS OBTAINED AS INVESTIGATOR
2007-2010: Ricerca e Sviluppo del Farmaco (CHEM-PROFARMA-NET). MIUR FIRB, Piattaforme Reti 2005 228.154
Title of the research: Sintesi, caratterizzazione biologica e farmacologica di nuove molecole organiche, biorganiche e naturali ad attività antidegenerativa (neuro o cardiovascolare), immunomodulatrice, antivirale ed anti-infettiva.
2009: Intramural research grant, Sapienza University of Rome 20.000
Title of the research: Effetti dell'ischemia cerebrale sul sistema endocannabinoide: studio delle alterazioni comportamentali e biochimiche
2012-2015: MIUR: Futuro in Ricerca 2012 228.798
Title of the research: Studio dei meccanismi epigenetici coinvolti nei disordini alimentari e nell'obesità per la scoperta di nuovi target farmacologici.
2013: Intramural research grant, Sapienza University of Rome 25.946
Title of the research: Cognitive decline and neuropsychiatric symptoms in Alzheimer s disease: can endocannabinoids help?
2016: Intramural research grant, Sapienza University of Rome 31600
Title of the research: Cognitive decline, depression and enhanced pain sensitivity as obesity-related comorbidities: possible protective effects of acylethanolamides
2021: Intramural research grant, Sapienza University of Rome 63787
Title of the research: TO BRAIN OR NOT TO BRAIN: evaluating the possible direct effects of oleoylethanolamide in the central nervous system.
2022: Grandi attrezzature scientifiche, Sapienza University of Rome 669800
Title of the research: High-throughput multiscale imaging of fixed and live biological samples

SCIENTIFIC PRODUCTION
AR is author of 57 papers published in peer reviewed journals included in the most important databases (SCOPUS, WOS, PUBMED), which include papers published in high impact journals (Neuropsychopharmacology, PNAS, Neuroscience Biobehavioural Reviews, Pharmacological Research) with a total number of 2131 citations and 30 H index (database: SCOPUS). AR is author, also, of more than 50 abstracts presented (also upon invitation) in prestigious national and international scientific meetings. AR is also author of a book chapter on the pharmacology of obesity.

OTHER SCIENTIFIC ACTIVITIES:
-2021: Chair of the Scientific Organizing Committee of a Symposium within the meeting of the Italian Society of Pharmacology: New possible pharmacological targets for the treatment of eating disorders .
-2021: Organizer of the Symposia proposal under 40 within the meeting of the Italian Society for Neuroscience. Symposium title: The inflamed brain in neurological diseases: moving from hypothesis to treatment . Organizers symposium: Adele Romano and Irene Paterniti.
-2021: Chair of the Scientific Organizing Committee of a Symposium within the meeting of the Italian Society for Neuroscience The inflamed brain in neurological diseases: moving from hypothesis to treatment .
-2015-present: referee of numerous scientific journals, including high impact journals.
-2020-present: member of the Review Editorial Board of the Journal Frontiers in Pharmacology (Experimental Pharmacology and Drug Discovery).
-2020-present: member of the scientific group Obesity, Metabolic Syndrome and Eating disorders of the Italian Society of Pharmacology
-2021: Guest Editor for the special issue of the International Journal of Molecular Sciences titled Therapeutic Potential of Targeting the Oxytocinergic System .
-2023: Guest Editor for the special issue on Physiology and Behavior journal titled Endocannabinoid and paracannabinoid signaling in motivation, reward, and addiction: physiological and pharmacological implications . The special issue is ongoing.
- Responsible of a cooperation agreement between the Department of Physiology and Pharmacology V. Erspamer (Sapienza University of Rome) and the SIMPE (Italian Society of Pediatric doctors, Campania section) with the project titled: Studio delle proprietà farmacologiche, del meccanismo d azione, nonché della tossicità di prodotti naturali e/o composti di sintesi a uso terapeutico in età pediatrica .

TEACHING ACTIVITY
-Research supervisor for undergraduate students of Pharmaceutical Biotechnology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Italy 2013-2015
- Member of the exam committee (cultore della materia), of the course of Pharmacology, Pharmacotherapy and Pharmaceutical Biotechnologies, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2013-present
- Lecture on laboratory techniques for undergraduate students of the Master Course in Medicinal Chemistry Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2012 and 2014
- Lecture in Pharmacology for undergraduate students of the Master Course in Pharmaceutical Biotechnologies Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2013 and 2014
- Lecture in Physiology of eating behaviour (2 hours) for undergraduate students of the Master Course in Pharmacy, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2014 and 2015
- Lectures (8 hours) in Pharmacology for undergraduate students of the Master Course in Pharmaceutical Biotechnologies, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2015
- Lectures (8 hours) in Pharmacology for undergraduate students of the Master Course in Pharmaceutical Biotechnologies, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2016
- Lectures (23 hours) on Pharmacology for undergraduate students of the Master Course in Medicinal Chemistry, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2017
- Course on in vivo laboratory techniques for PhD students of the PhD Program of Pharmacology and Toxicology, Sapienza University of Rome, Italy 2017 (1CFU/ 4 hours).
- Course on pharmacology (Title: regulation of eating behaviour and pharmacological targets for the treatment of eating disorders) for PhD students of the course of Pharmacology and Toxicology, Sapienza University of Rome, Italy 2018 (1CFU/ 4 hours).
- Lectures (12 hours) on Pharmacology for undergraduate students of the Master Course in Pharmacy, Sapienza University of Rome, Italy 2018
- Course owner of the lectures on Pharmacology (8 hours), Title: Searching for novel pharmacological targets for the treatment of obesity for PhD student of the PhD Program in Pharmacology and Veterinary Physiology of the University of Zurich, Institute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Switzerland, 2018.
- Course owner of in vivo techniques for the evaluation of xenobiotic activity for PhD students of the course of Pharmacology and Toxicology, Sapienza University of Rome, Italy 2019-2022 (1CFU/ 4 hours).
-Course owner of the Course of General Pharmacology and Pharmacotherapy for undergraduate students of the Master Course in Applied Pharmaceutical Sciences Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy Jenuary 2019- December 2022. (12 CFU/96 hours)
- Course owner of the Course of Pharmacologic sciences for undergraduate students of the Master Course in Scientific Biomedical Communication , Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy October 2020-September 2022. (6CFU/48 hours)
- Course owner of the Course of Pharmacology for undergraduate students of the Master Course in Orthoptic and ophtalmologic assistance , Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy October 2021- September 2022 (2CFU/ 8 hours).
- Course owner of the Course of Toxicology for undergraduate students of the Master Course in Pharmacy , Faculty of Pharmacy and Medicine Sapienza University of Rome, October 2022- present (12 CFU/96 hours)
- Course owner of the Course of Pharmacovigilance and Toxicology for undergraduate students of the Master Course in Applied Pharmaceutical Sciences Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy October 2022- present (9CFU/72 hours)
-Curse owner of the Course of Pharmacology at the graduate school in ophthalmology, Faculty of Medicine and Surgery, Sapienza University of Rome, Italy, November 2021-present (2CFU/20 hours).

MENTORSHIP ACTIVITY
-Mentor of 3 PhD students of the PhD course in Pharmacology and Roxicology (Nisha Zahid, Martina Santoro e Christian Sepe) at Sapienza University of Rome (November 2021-present, November 2022-present, November 2023-present respectively).
-Mentor of 15 master theses in Applied Pharmaceutical Sciences, Scientific Biomedical Communication and Pharmacy at Sapienza University of Rome (2020-present)
-Research supervisor (co-relatore) of master students theses (more than 12) in Pharmaceutical Biotechnology, Medicinal Chemistry, Pharmacy at Sapienza University of Rome (2013-present).
-Responsible of a 1-year post-Doc position (Assegno di Ricerca) for the research: Evaluation of PPAR-agonists pharmacological treatment on autophagy response in a preclinical model of diet-induced obesity . (Vahideh Abedi 06/02/2023-present)
- Research supervisor and PI of a research project for mobility abroad of Ph.D students of Sapienza (progetti congiunti). Title of the project Unrevealing the role of the neuropeptide oxytocin in anorexia nervosa: from preclinical to clinical . The project is ongoing and the Ph. D student Barbara Eramo is at the laboratory of Dr. Ida Nilsson at Karolinska Institutet (Stockholm- Schweiz).
- Responsible of a 1-year post-Doc position (Assegno di Ricerca) for the research: Regulation of autophagy by N-acylethanolamines as a promising approach for the treatment of inflammatory-based diseases: from neurodegeneration to metabolic disorders . (procedure in progress)

OTHER ACADEMIC ACTIVITIES
-2017-present: Member of the Board of Professors (Colleggio dei Docenti) of the Ph.D program in Pharmacology and Toxicology, Sapienza University of Rome
- November 2020-Dicemer 2023: Nominated secretary of the Consiglio del Corso di Studi of the course of Applied Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, Sapienza University of Rome.
-January 2022-present: nominated member of the Quality Committee of the course of Applied Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, Sapienza University of Rome.

LIST OF PUBBLICATIONS
1. Gaetani S, Dipasquale P, Romano A, Righetti L, Cassano T, Piomelli D. and Cuomo V. The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. International Review of Neurobiology 2009, 85:57-72.
2. Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, and Piomelli D. The fat-induced satiety factor OEA suppresses feeding through central release of oxytocin. Journal of Neuroscience 2010, 30:8096-101.
3. Cassano T, Gaetani S, Macheda T, Laconca L, Romano A, Morgese MG, Cimmino CS, Chiarotti F, Bambico FR, Gobbi G, Cuomo V, and Piomelli D. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology 2011, 214:465-76.
4. Dipasquale P*, Romano A*, Cianci S, Rigetti L, Gaetani S. Oleoylethanolamide: a new player in energy metabolism control. Role in Food intake. Drug Discovery Today: Disease Mechanisms. 2010, 7: e169 e174. *Equal contribution.
5. Cassano T*, Romano A*, Macheda T, Colangeli R, Petrella A, LaFerla FM, Cuomo V, Gaetani S. Olfactory memory is impaired in a triple transgenic model of Alzheimer disease. Behavioural Brain Research 2011, 224:408-12. *Equal contribution.
6. Cassano T, Serviddio G, Gaetani S, Romano A, Dipasquale P, Cianci S, Bellanti F, Laconca L, Romano AD, Padalino I, LaFerla FM, Nicoletti F, Cuomo V, Vendemiale G. Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiology of Aging 2012, 33:1121 e1-12.
7. Romano A, Cassano T, Tempesta B, Cianci S, Dipasquale P, Coccurello R, Cuomo V, Gaetani S. The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. Peptides 2013, 49:21-6.
8. Romano A, Potes C, Tempesta B, Cassano T, Cuomo V, Lutz T, and Gaetani S. Hindbrain noradrenergic input to the hypothalamic PVN mediates the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide. American Journal of Physiology, Endocrinology and Metabolism 2013, 305(10):E1266-73.
9. Aureli C, Cassano T, Masci A, Francioso A, Martire S, Cocciolo A, Chichiarelli S, Romano A, Gaetani S, Mancini P, Fontana M, d'Erme M, Mosca L. 5-S-Cysteinyldopamine neurotoxicity: influence on the expression of alpha-Synuclein and of ERp57 in cellular and animal models of Parkison s disease. Journal of Neuroscience Research 2014, 92(3):347-58.
10. Bedse G*, Romano A*, Cianci S, Lavecchia AM, Pace L, Elphick MR, LaFerla FM, Vendemiale G, Grillo C, Altieri F, Cassano T and Gaetani S. Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer s disease. Journal of Alzheimer s disease 2014, 40 (3):701-12. *Equal contribution
11. Romano A, Coccurello R, Giacovazzo G, Bedse G, Moles A, Gaetani S. Oleoylethanolamide: a novel potential pharmacological alternative to cannabinoid antagonists for the control of appetite. BioMed Research International, 2014, 2014:203425.
12. Romano A*, Karimian Azari E, Tempesta B, Mansouri A, Micioni Di Bonaventura MV, Ramachandran D, Lutz TA, Bedse G, Langhans W, Gaetani S*. High dietary fat intake influences the activation of specific hindbrain and hypothalamic nuclei by the satiety factor oleoylethanolamide. Physiology and Behaviour, 2014, 136:55-62. * Co-corresponding authors
13. Karimian Azari E, Ramachandran D, Weibel S, Arnold M, Romano A, Gaetani S, Langhans W, Mansouri A. Vagal afferents are not necessary for the satiety effect of the gut lipid messenger oleoylethanolamide (OEA). The American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 2014, 307(2): R167-78.
14. Provensi G, Munari L, Umehara H, Coccurello R, Giacovazzo G, Galeotti N, Nosi D, Gaetani S, Romano A, Moles A, Blandina P and Passani MB. Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake. Proceedings of the National Academy of Sciences, 2014, 111(31): 11527-32.
15. Romano A, Pace L, Tempesta B, Lavecchia AM, Macheda T, Bedse G, Petrella A, Vendemiale G, Gaetani S, Cassano T. Depressive-like behaviour is paired to monoaminergic alteration in a murine model of Alzheimer's disease. International journal of Neuropsycopharmacology 2014, 18(4).
16. Bedse G, Colangeli R, Lavecchia AM, Romano A, Altieri F, Cifani C, Cassano T, Gaetani S. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. European Neurophsycopharmacology, 2014, 24:1511-23.
17. Micioni Di Bonaventura MV, Ciccocioppo R, Romano A, Bossert J, Rice K, Ubaldi M, St. Laurent R, Gaetani S, Massi M, Shaham Y, Cifani C. Role of bed nucleus of the stria terminalis corticotrophin-releasing factor receptors in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction. Journal of Neuroscience, 2014, 34 :11316-24.
18. D'Addario C, Micioni di Bonaventura MV, Pucci M, Romano A, Gaetani S, Ciccocioppo R, Cifani C, Maccarrone M. Endocannabinoid signaling and food addiction. Neuroscience & Biobehavioral Reviews, 2014, 47:203-24.
19. Bedse G, Romano A, Lavecchia AM, Cassano T and Gaetani S. The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer disease. Journal of Alzheimer s disease, 2015, 43(4):1115-36.
20. Bedse G, Romano A, Tempesta B, Lavecchia MA, Pace L, Bellomo A, Duranti A, Micioni di Bonaventura MV, Cifani C, Cassano T, Gaetani S. Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress. Journal of Neuroscience Research, 2015, 93:777-87.
21. Cifani C, Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Di Francesco A, Maccarrone M, D'Addario C. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction? Frontiers in Neuroscience, 2015, 9:187.
22. Romano A, Tempesta B, Provensi G, Passani MB, Gaetani S. Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? Frontiers in Pharmacology, 2015, 6: 137.
23. Giudetti A, Romano A, Lavecchia M, Gaetani S.The role of brain cholesterol and its oxidized products in Alzheimer's disease. Current Alzheimer Research, 2016, 13:198-205.
24. Pucci M, Micioni Di Bonaventura MV, Giusepponi ME, Romano A, Filaferro M, Maccarrone M, Ciccocioppo R, Cifani C, D Addario C. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. Addiction Biology, 2016, 21:1168-1185.
25. Romano A, Tempesta B, Micioni Di Bonaventura MV, Gaetani S. From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders. Frontiers in Neuroscience, 2016, 9:497.
26. Gaetani S, Romano A, Provensi G, Ricca V, Lutz T, Passani MB. Eating disorders: from bench to bedside and back. Journal of Neurochemistry. 2016, 139(5):691-699.
27. Romano A, Koczwara JB, Gallelli CA, Vergara D, Bonaventura MV, Gaetani S, Giudetti AM. Fats for thoughts: An update on brain fatty acid metabolism. The International Journal of Biochemistry & Cell Biology. 2017, 84:40-45.
28. Romano A, Serviddio G, Calcagnini S, Villani R, Giudetti AM, Cassano T, Gaetani S. Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal. Free Radical Biology & Medicine 2017, 111:281-293.
29. Micioni Di Bonaventura MV, Lutz TA, Romano A, Pucci M, Geary N, Asarian L, Cifani C. Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative nonreward stress in female rats. International Journal of eating disorders, 2017, 50(6):624-635.
30. Cassano T, Calcagnini S, Pace L, De Marco F, Romano A, Gaetani S. Cannabinoid receptor 2 signaling in neurodegenerative disorders: from pathogenesis to a promising therapeutic target. Frontiers in Neuroscience, 2017, 11:30.
31. Bellanti F, Iannelli G, Blonda M, Tamborra R, Villani R, Romano A, Mazzoccoli G, Vinciguerra M, Vendemiale G, Cassano T, Serviddio G. Alterations of clock gene RNA expression in brain regions of the triple transgenic model of Alzheimer Disease. Journal of Alzheimer s disease, 2017, 017;59(2):615-631.
32. Romano A, Gallelli CA, Koczwara JB, Braegger FE, Micioni Di Bonaventura MV, Cifani C, Lutz TA, Vitalone A, Falchi M, Cassano T, Gaetani S. Role of the area postrema in the hypophagic effects of oleoylethanolamide. Pharmacological Research, 2017, 122:20-34.
33. Roberto Coccurello*, Romano A*, Giacovazzo G, Tempesta B, Fiore M, Giudetti AM, Marrocco I, Altieri F, Moles A, Gaetani S. Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat. European Journal of Nutrition, 2018, 57(4):1485- 1498. *equal contribution
34. Bronzuoli MR, Facchinetti R, Steardo L Jr, Romano A, Stecca C, Passarella S, Steardo L, Cassano T, Scuderi C. Palmitoylethanolamide dampens reactive astrogliosis and improves neuronal trophic support in a triple transgenic model of Alzheimer s disease: in vitro and in vivo evidence. Oxidative Medicine and Cellular Longevity, 2018, 4720532.
35. Giudetti AM, Testini M, Vergara D, Priore P, Damiano F, Gallelli CA, Romano A, Villani R, Cassano T, Siculella L, Gnoni GV, Moles A, Coccurello R, Gaetani S. Chronic psychosocial defeat differently affects lipid metabolism in liver and white adipose tissue and induces hepatic oxidative stress in mice fed a high-fat diet. The FASEB Journal 2018, in press. doi: 10.1096/fj.201801130R.
36. Gallelli CA, Calcagnini S, Romano A, Koczwara JB, de Ceglia ML, Dante D, Villani R, Giudetti AM, Cassano T, Gaetani S. Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues. Antioxidants (Basel), 2018, 7 (7). doi: 10.3390/antiox7070093.
37. Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C, Cifani C. Regulation of adenosine A(2A) receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. Journal of Psychopharmacology. 2019 Jun 4:269881119845798. doi: 10.1177/0269881119845798.
38. Cassano T, Magini A, Giovagnoli S, Polchi A, Calcagnini S, Pace L, Lavecchia MA, Scuderi C, Bronzuoli MR, Ruggeri L, Gentileschi MP, Romano A, Gaetani S, De Marco F, Emiliani C, Dolcetta D. Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease. Experimental Neurology 2019 Jan; 311:88-105. doi: 10.1016/j.expneurol.2018.09.011.
39. Cassano T, Calcagnini S, Carbone A, Bukke VN, Orkisz S, Villani R, Romano A, Avolio C, Gaetani S. Pharmacological Treatment of Depression in Alzheimer's Disease: A Challenging Task. Frontiers in Pharmacology. 2019 Sep 27;10:1067. doi: 10.3389/fphar.2019.01067. eCollection 2019.
40. Cifani C, Avagliano C, Micioni Di Bonaventura E, Giusepponi ME, De Caro C, Cristiano C, La Rana G, Botticelli L, Romano A, Calignano A, Gaetani S, Micioni Di Bonaventura MV, Russo R. Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase. Frontiers in Pharmacology. 2020 Mar 16;11:266. doi: 10.3389/fphar.2020.00266. eCollection 2020.
41. Romano A, Friuli M, Cifani C, Gaetani S. Oxytocin in the neural control of eating: At the crossroad between homeostatic and non-homeostatic signals. Neuropharmacology. 2020 Apr 4;171:108082. doi: 10.1016/j.neuropharm.2020.108082.
42. Romano A*, Micioni Di Bonaventura MV*, Gallelli CA, Koczwara JB, Smeets D, Giusepponi ME, De Ceglia M, Friuli M, Micioni Di Bonaventura E, Scuderi C, Vitalone A, Tramutola A, Altieri F, Lutz TA, Giudetti AM, Cassano T, Cifani C, Gaetani S. Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder. Neuropsychopharmacology. 2020 Apr 30. doi: 10.1038/s41386-020-0686-z. *Equal contribution
43. Anna Maria Giudetti, Maria Vittoria Micioni, Di Bonaventura, Alessandra Ferramosca, Serena Longo, Emanuela Micioni Di Bonaventura, Marzia Friuli, Adele Romano, Silvana Gaetani, Carlo Cifani. Brief daily access to cafeteria-style diet impairs hepatic metabolism even in the absence of excessive body weight gain in rats. The FASEB Journal. 2020 Jul;34(7):9358-9371. doi:10.1096/fj.201902757R.
44. Luca Botticelli, Emanuela Micioni Di Bonaventura, Fabio Del Bello, Gianfabio Giorgioni, Alessandro Piergentili, Adele Romano, Wilma Quaglia, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura. Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors. Nutrients. 2020 Jul 30;12(8):2288. doi: 10.3390/nu12082288.
45. Romano A, Friuli M, Del Coco L, Longo S, Vergara D, Del Boccio P, Valentinuzzi S, Cicalini I, Fanizzi FP, Gaetani S, Giudetti AM. Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPAR /SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis. Nutrients. 2021 Jan 27;13(2):394. doi: 10.3390/nu13020394.
46. Rani B, Santangelo A, Romano A, Koczwara JB, Friuli M, Provensi G, Blandina P, Casarrubea M, Gaetani S, Passani MB, Costa A. Brain histamine and oleoylethanolamide restore behavioral deficits induced by chronic social defeat stress in mice. Neurobiology of Stress. 2021 Mar 17;14:100317. doi: 10.1016/j.ynstr.2021.100317.
47. Conte E, Romano A, De Bellis M, de Ceglia M, Rosaria Carratù M, Gaetani S, Maqoud F, Tricarico D, Camerino C. Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice. Journal of Endocrinology. 2021 May;249(2):135-148. doi: 10.1530/JOE-20-0346.
48. Giudetti AM, Vergara D, Longo S, Friuli M, Eramo B, Tacconi S, Fidaleo M, Dini L, Romano A*, Gaetani S*. Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats. Antioxidants (Basel). 2021 Aug 14;10(8):1289. doi: 10.3390/antiox10081289. *Equal contribution
49. Baldi E, Costa A, Rani B, Passani MB, Blandina P, Romano A, Provensi G. Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders? International Journal of Molecular Sciences. 2021 Sep 16;22(18):10000. doi: 10.3390/ijms221810000.
50. Friuli M, Eramo B, Valenza M, Scuderi C, Provensi G, Romano A*. Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases. International Journal of Molecular Sciences. 2021 Sep 23;22(19):10250. doi: 10.3390/ijms221910250. *Corresponding author
51. Di Giacomo S, Percaccio E, Gullì M, Romano A, Vitalone A, Mazzanti G, Gaetani S, Di Sotto A. Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review. Nutrients. 2022 Sep 8;14(18):3709. doi: 10.3390/nu14183709.
52. Micioni Di Bonaventura E, Botticelli L, Del Bello F, Giorgioni G, Piergentili A, Quaglia W, Romano A, Gaetani S, Micioni Di Bonaventura MV, Cifani C. Investigating the role of the central melanocortin system in stress and stress-related disorders. Pharmacol Res. 2022 Nov;185:106521. doi: 10.1016/j.phrs.2022.106521.
53. Romano A, Provensi G. Therapeutic Potential of Targeting the Oxytocinergic System. Int J Mol Sci. 2022 Oct 31;23(21):13295. doi: 10.3390/ijms232113295.
54. de Ceglia M, Micioni Di Bonaventura MV, Romano A, Friuli M, Micioni Di Bonaventura E, Gavito AL, Botticelli L, Gaetani S, de Fonseca FR, Cifani C. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. Int J Eat Disord. 2023 Feb 25. doi: 10.1002/eat.23917
55. Cassano T, Giamogante F, Calcagnini S, Romano A, Lavecchia AM, Inglese F, Paglia G, Bukke VN, Romano AD, Friuli M, Altieri F, Gaetani S. PDIA3 Expression Is Altered in the Limbic Brain Regions of Triple-Transgenic Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2023 Feb 3;24(3):3005. doi: 10.3390/ijms24033005.
56. Romano A*, Friuli M, Eramo B, Gallelli CA, Koczwara JB, Azari EK, Paquot A, Arnold M, Langhans W, Muccioli GG, Lutz TA and Gaetani S (2023) To brain or not to brain : evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system. Front. Endocrinol. 14:1158287. doi: 10.3389/fendo.2023.1158287. *Corresponding author.
57. Tacconi S, Longo S, Guerra F, Moliterni C, Friuli M, Romano A, Gaetani S, Paradiso V.M., Difonzo G, Caponio F, Lofrumento D, Vergara D, Bucci C, Dini L, Giudetti A.M. (2023). An aqueous olive leaf extract (OLE) ameliorates parameters of oxidative stress associated with lipid accumulation and induces lipophagy in human hepatic cells. Food & Function. DOI: 10.1039/d3fo00817g
CONTRIBUTION TO TEXT BOOKS

Romano A., Gallelli C.A., Gaetani S (2019). Terapia farmacologica dell obesità. In: Manuale di Farmacoterapia. Edited by: Edizioni Idelson Gnocchi 1908. ISBN 978-88-79476874.
INVITED LECTURES AT INTERNATIONAL AND NATIONAL CONFERENCES

1. EBPS Workshop on Eating Behaviour and Obesity , Lecce, September 2012. The satiety signal Oleoylethanolamide stimulates Oxytocin release from hypothalamic neurons. A. Romano, T. Cassano, P. Dipasquale, T. Lutz, S. Gaetani.

2. XXI Annual Meeting of the Society for the Study of Ingestive Behavior, New Orleans LA, July 2013. Hindbrain noradrenergic input to paraventricular hypothalamus mediate the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide. A. Romano, C. Potes, B. Tempesta, V. Cuomo, T. Lutz and S. Gaetani.

3. XVI Annual Meeting of the Italian Society of Neuroscience (SINS), Cagliari, Italy October 2015. Role of oleoylethanolamide in the gut-to-brain axis : possible implications for the treatment of obesity and eating disorders . Adele Romano.

4. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. High dietary fat intake influences the central effects of the satiety factor oleoylethanolamide: possible implications for obesity management A. Romano, S. Gaetani.

5. 8th Swiss Winter Conference on Ingestive Behavior, Saint Morritz February, March 2017. Role of oleoylethanolamide in the gut-to-brain axis : possible implications for the treatment of obesity and eating disorders Adele Romano, Cristina Anna Gallelli, Justina Barbara Koczwara, Maria Vittoria Micioni di Bonaventura, Mariaelena Giusepponi, Carlo Cifani, Thomas Lutz and Silvana Gaetani

6. XVII Annual Meeting of the Italian Society of Neuroscience (SINS), Ischia, Italy October 2017. Role of the satiety signal oleoylethanolamide in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction Adele Romano, Maria Vittoria Micioni di Bonaventura, Cristina Anna Gallelli, Justina Barbara Koczwara, Mariaelena Giusepponi, Carlo Cifani and Silvana Gaetani

7. 9th Swiss Winter Conference on Ingestive Behavior, Saint Morritz February, February 2018.
Effects of the satiety signal oleoylethanolamide on binge-like food consumption in female rats Adele Romano, Maria Vittoria Micioni di Bonaventura, Cristina Anna Gallelli, Justina Barbara Koczwara, Mariaelena Giusepponi, Tommaso Cassano, Carlo Cifani and Silvana Gaetani.

8. National congress of the Italian Society of Pharmacology, Firenze, November 2019 Satiety factor oleoylethanolamide prevents binge-like palatable food consumption induced by stress in female rats with a history of food restriction A. Romano, M. V. Micioni Di Bonaventura, C. A. Gallelli, J. B. Koczwara, M. E. Giusepponi, T. Cassano, C. Cifani, S. Gaetani.

9. National congress of the Italian Society of Pharmacology, Digital Edition, March 2021 Effects of oleoylethanolamide in a rat model of diet-induced obesity: from the modulation of microbiota to neuroprotective properties. A. Romano

10. International conference on neurology and psychiatric disorders, theme: "Amelioration in innovations with the advancement in neurology and psychiatric disorders" June 2022 digital congress. Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder. A. Romano, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Silvana Gaetani.

11. National congress of the Italian Society of Pharmacology, Rome November 2022. The oxytocinergic system as a possible target for the treatment of obesity and aberrant eating patterns . Adele Romano.

12. 13th Swiss Winter Conference on Ingestive Behavior, Saint Morritz February, February 2023.
To brain or not to brain : evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system.

ORAL AND POSTER PRESENTATIONS AT NATIONAL AND INTERNATIONAL CONFERENCES

1. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Washington, DC, November 2008 The effects of oleoylethanolamide on feeding behaviour involve hypothalamic oxytocin neurons S Gaetani, J Fu, P Dipasquale, L Righetti, A Romano, V Cuomo, D Piomelli.
2. Biennal Meeting EUROPEAN BEHAVIOURAL PHARMACOLOGY SOCIETY (EBPS) Rome, September 2009 The effects of oleoylethanolamide on feeding behaviour involve hypothalamic oxytocin neurons S Gaetani, J Fu, T Cassano, P Dipasquale, A Romano, L Righetti, S Cianci, L Laconca, E Giannini, S Scaccianoce, J Mairesse, V Cuomo, D Piomelli.
3. Biennal Meeting EUROPEAN BEHAVIOURAL PHARMACOLOGY SOCIETY (EBPS) Rome, September 2009 Social memory impairment in a triple-transgenic mouse model of Alzheimer s disease is accompanied by monoaminergic alterations A Romano, T Cassano, S Gaetani, L Laconca, T Macheda, L Righetti, S Cianci, M G Morgese, T Mastrantonio, S Oddo, F M Laferla, V Cuomo.
4. Biennal Meeting EUROPEAN BEHAVIOURAL PHARMACOLOGY SOCIETY (EBPS) Rome, September 2009 Acute administration of oleoylethanolamide affects behavioral satiety sequence in mice: a comparative study with rimonabant effects L Righetti, A Romano, R Coccurello, P Dipasquale, S Bellantuono, F R D Amato, V Cuomo, A Moles, S Gaetani.
5. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Chicago, October 2009 Social memory impairment in a triple-transgenic mouse model of Alzheimer s disease is accompanied by monoaminergic alterations A Romano, T Cassano, S Gaetani, L Laconca, T Macheda, L Righetti, S Cianci, M G Morgese, T Mastrantonio, S Oddo, F M Laferla, V Cuomo.
6. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Chicago, October 2009 Acute administration of oleoylethanolamide affects behavioral satiety sequence in mice: A comparative study with rimonabant effects L Righetti, A Romano, R Coccurello, P Dipasquale, S Bellantuono, F R D Amato, V Cuomo, A Moles, S Gaetani.
7. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Chicago, October 2009 Chronic psychosocial stress enhances intake of high fat diet and reverse the high fat diet induced increased expression of POMC in the hypothalamus of C57/BL6 mice A Moles, S Bellantuono, L Righetti, R Coccurello, A Romano, P Dipasquale, S Remiddi, S Cianci, F R D'Amato, S Gaetani.
8. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Chicago, October 2009 The satiety factor oleoylethanolamide enhances central and peripheral oxytocinergic tone P Dipasquale, S Gaetani, J Fu, T Cassano, A Romano, L Righetti, S Cianci, L Laconca, S Scaccianoce, J Mairesse, V Cuomo, D Piomelli.
9. National congress of the Italian Society of Pharmacology, Rimini, October 2009 Social memory impairment in a triple-transgenic mouse model of Alzheimer s disease is accompanied by monoaminergic alterations A Romano, T Cassano, S Gaetani, L Laconca, T Macheda, L Righetti, S Cianci, M G Morgese, T Mastrantonio, S Oddo, F M Laferla, V Cuomo.
10. National congress of the Italian Society of Pharmacology, Rimini, October 2009 Acute administration of oleoylethanolamide affects behavioral satiety sequence in mice: a comparative study with rimonabant effects L Righetti, A Romano, R Coccurello, P Dipasquale, S Bellantuono, F R D Amato, V Cuomo, A Moles, S Gaetani.
11. National congress of the Italian Society of Pharmacology, Rimini, October 2009 The effects of oleoylethanolamide on feeding behaviour involve hypothalamic oxytocin neurons P Dipasquale, S Gaetani, J Fu, T Cassano, A Romano, L Righetti, S Cianci, L Laconca, E Giannini, S Scaccianoce, D Piomelli, V Cuomo.
12. 16th World Congress of Basic and Clinical Pharmacology Copenaghen, July 2010 The fatinduced satiety factor OEA suppresses feeding through central release of oxytocin A Romano, S Gaetani, J Fu, T Cassano, P Dipasquale, L Righetti, S Cianci, L Laconca, E Giannini, S Scaccianoce, D Piomelli, V Cuomo.
13. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), San Diego, November 2010 Glutamate and mitochondrial deficits accompany olfactory memory loss in triple-transgenic mice, a model of Alzheimer s disease T Cassano, S Gaetani, G Serviddio, T Macheda, L Laconca, P Dipasquale, S Cianci, A Romano, I Padalino, S Oddo, F Laferla, G Vendemiale, F Nicoletti, V Cuomo.
14. National Congress of the Italian Society of Pharmacology, Bologna, Settembre 2011 Glutamatergic alterations and mitocondrial impairment in a murine model of Alzheimer s disease A Romano, T Cassano, P Dipasquale, S Cianci, A Petrella, S Cimino, S Gaetani, V Cuomo.
15. 20th Annual Meeting of the Society for the Study of Ingestive Behavior, Zurich, July 2012 Oleoylethanolamide is a gut-derived satiety factor controlling feeding behaviour through the activation of hypothalamic oxytocinergic neurons. A Romano, S Gaetani, V Cuomo.
16. 16th Seminario Nazionale assegnisti e dottorandi organized by the Italian Society of Pharmacology, Rimini 16-19 September 2012. Olfactory memory results impaired in a triple transgenic model of Alzheimer disease . B Tempesta, A Romano, M Lavecchia, T Cassano, S Gaetani, V Cuomo.
17. National Congress of the Italian Society of Pharmacology Torino, October 2013 Hindbrain noradrenergic input to paraventricular hypothalamus mediates the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide A. Romano, C. Potes, B. Tempesta, T. Lutz, S. Gaetani, V. Cuomo.
18. National Congress of the Italian Society of Pharmacology Torino, October 2013 Mice exposed to chronic psychosocial stress overeat palatable energy dense food and show altered expression of selected neuropeptides in key brain areas B Tempesta, A Romano, R Coccurello, S Cianci, S Bellantuono, A Moles, S Gaetani, V Cuomo.
19. National Congress of the Italian Society of Pharmacology Torino, October 2013 Distribution patterns of CB1 mRNA and protein in a triple transgenic mouse model of Alzheimer s disease: a longitudinal study M Lavecchia, G Bedse, A Romano, M Elphick, S Gaetani, T Cassano and V Cuomo.
20. Neuroscience meeting (SOCIETY FOR Washington (USA), November 2014 High dietary fat intake influences the activation of specific hindbrain and hypothalamic nuclei by the satiety factor oleoylethanolamide B. Tempesta, A. Romano, E. Karimian, Azari, A. Mansouri, MV Micioni Di Bonaventura, T. Lutz, G. Bedse, W. Langhans, S. Gaetani.
21. 18th National congress of the Italian Society of Neuropsychopharmacology, June 2014 Epigenetic regulation of A2A gene transcription in a model of binge eating in the amygdala complex of female rats C Cifani, MV Micioni Di Bonaventura, M Pucci, ME Giusepponi, C Lambertucci, R Volpini, A Romano, S Gaetani, M Massi, M Maccarrone, C D Addario.
22. 9th FENS Forum July 2014 Role of CRF receptors in compulsive food consumption in a model of binge eating in female rats . MV Micioni Di Bonaventura, M Ubaldi, JB Bossert, RM St. Laurent, ME Giusepponi, A Romano, S Gaetani, R Ciccocioppo, Y Shaham, C Cifani.
23. 17th Seminar of PhD Students and Research Fellows of the Italian Society of Pharmacology September, 2014 Effect of adenosine A2A receptor ligands on binge eating episodes in female rats MV Micioni Di Bonaventura, M Pucci, ME Giusepponi, A Romano, C Lambertucci, R Volpini, M Maccarrone, C D Addario, C Cifani.
24. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption ME Giusepponi, MV.Micioni Di Bonaventura, M Pucci, A Romano, M Maccarrone, R Ciccocioppo, C D'Addario, C.Cifani.
25. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. Vagal afferents are not strictly necessary for the anorectic effect of the endogenous lipid oleoylethanolamide CA Gallelli*, A Romano*, JB Koczwara, EK Azari, W Langhans, S Gaetani *equal contribution.
26. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. Novel insights on the central mechanisms mediating the hypophagic effects of oleoylethanolamide JB Koczwara*, A Romano*, CA Gallelli, FE Braegger, TA Lutz, S Gaetani *equal contribution.
27. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. Estradioldependent decreases in emotional binge-like eating are associated with decreased brain pERK expression in ovariectomized rats MV Micioni Di Bonaventura, TA Lutz, A Romano, L Asarian, C Cifani.
28. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction? C Cifani, MV Micioni Di Bonaventura, ME Giusepponi, M Pucci, A Romano, A Di Francesco, M Maccarrone, C D'Addario.
29. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. Effect of oleoylethanolamide in an animal model of binge eating and in a model of reinstatement of high- fat food seeking ME Giusepponi, MV Micioni Di Bonaventura, A Romano, S Gaetani, C Cifani.
30. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. Comorbid depression in Alzheimer's disease (AD): novel observations from a longitudinal study in the tripletransgenic mouse model AM Lavecchia, A Romano, L Pace, T Cassano, S Gaetani
31. 24th Annual Meeting of the Society for the Study of Ingestive Behavior, Porto, Portugal 2016. New advances on the brain mechanisms underlying 232 the hypophagic effect of oleoylethanolamide: role of the area postrema. A. Romano, C.A. Gallelli, J.B. Koczwara, F.E. Braegger, T.A. Lutz, S. Gaetani.
32. 24th Annual Meeting of the Society for the Study of Ingestive Behavior, Porto, Portugal 2016. Estradiol-dependent decreases in emotional binge-like eating are associated with decreased brain pERK expression in ovariectomized rats. MV. Micioni di Bonaventura, TA Lutz, A Romano, L. Asarian, C Cifani.
33. National Congress for PhD students in Neuroscience organized from the Italian Society of Neuroscience, Napoli, February 2017. Oleoylethanolamide: a fatty gut lipid to combat obesity and eating disorders JB Koczwara, CA Gallelli, A Romano, MV Micioni di Bonaventura, ME Giusepponi, T Cassano, C Cifani, S Gaetani.
34. Biennal Meeting of the European Behavioural Pharmacology Society (EBPS), Heraklion, Crete, Greece August- September 2017. Effects of subdiaphragmatic deafferentation on oleoylethanolamide-induced Fos expression in brain areas involved in the control of feeding behaviour . JB Koczwara, A Romano, CA Gallelli, EK Azari, W Langhans, S Gaetani.
35. Biennal Meeting EUROPEAN BEHAVIOURAL PHARMACOLOGY SOCIETY (EBPS), Heraklion, Crete, Greece August-September 2017. Effects of oleoylethanolamide on mesolimbic dopaminergic transmission in an animal model of binge eating . CA Gallelli, A Romano, JB Koczwara, MV Micioni Di Bonaventura, ME Giusepponi, T Cassano, C Cifani, S Gaetani.
36. Biennal Meeting of the European Behavioural Pharmacology Society, Heraklion, Crete, Greece August-September 2017. Role of the area postrema in the hypophagic effects of oleoylethanolamide A Romano, CA Gallelli, JB Koczwara, MV Micioni di Bonaventura, C Cifani, FE Braegger, T Lutz, S Gaetani.
37. Biennal Meeting of the European Behavioural Pharmacology Society, Heraklion, Crete, Greece August-September 2017. Everolimus rescues the early learning and memory deficits and ameliorates the AD-like pathology in the 3×tg-AD mice . Calcagnini S., Romano A., Gaetani S., Dolcetta D. and Cassano T.
38. XVII Annual Meeting of the Italian Society of Neuroscience (SINS), Lacco Ameno Ischia, Italy October 2017. Everolimus rescues the early learning and memory deficits and ameliorates the ADlike pathology in the 3×tg-AD mice . Calcagnini S., Romano A., Gaetani S., Dolcetta D. and Cassano T.
39. XVII Annual Meeting of the Italian Society of Neuroscience (SINS), Lacco Ameno Ischia, Italy October 2017. Effects of Oleoylethanolamide on mesolimbic dopaminergic transmission in an animal model of binge eating . CA Gallelli, A Romano, JB Koczwara, MV Micioni Di Bonaventura, ME Giusepponi, T Cassano, C Cifani, S Gaetani.
40. XVII Annual Meeting of the Italian Society of Neuroscience (SINS), Lacco Ameno Ischia, Italy October 2017. Effects of subdiaphragmatic deafferentation on oleoylethanolamide-induced Fos expression in brain areas involved in the control of feeding behaviour . JB Koczwara, A Romano, CA Gallelli, EK Azari, W Langhans, S Gaetani.
41. National congress of the Italian Society of Pharmacology, Rimini, October 2017. Effects of subdiaphragmatic deafferentation on oleoylethanolamide-induced Fos expression in brain areas involved in the control of feeding behaviour . JB Koczwara, A Romano, CA Gallelli, EK Azari, W Langhans, S Gaetani.
42. National congress of the Italian Society of Pharmacology, Rimini, October 2017. Role of the area postrema in the hypophagic effects of oleoylethanolamide . CA Gallelli, A Romano, JB Koczwara, MV Micioni di Bonaventura, C Cifani, FE Braegger, T Lutz, S Gaetani.
43. National congress of the Italian Society of Pharmacology, Rimini, October 2017. Chronic Oleoylethanolamide Treatment in Diet-Induced Obese Rats: Effect on Food Intake, Body Weight and Gut Microbiota . A Romano, ML Rastelli, JB Koczwara, CA Gallelli, PD Cani, S Gaetani.
44. National Congress for PhD students in Neuroscience organized from the Italian Society of Neuroscience, Napoli, February 2018. Effects of the satiety signal oleoylethanolamide on binge-like food consumption in female rats CA Gallelli, A Romano, MV Micioni Di Bonaventura, JB Koczwara, ME Giusepponi, T Cassano, C Cifani, S Gaetani.
45. National Congress for PhD students in Neuroscience organized from the Italian Society of Neuroscience, Napoli, February 2018. Anti-obesity effects of oleoylethanolamide in a rodent model of diet-induced obesity ML de Ceglia, A Romano, M Rastelli, A Everard, JB Koczwara, CA Gallelli, PD Cani, S Gaetani.
46. 28th Annual Symposium of the International Cannabinoid Research Society (ICRS), Leiden, The Netherlands, July 2018. The selective inhibition of FAAH ameliorates cognitive decline, depressivelike symptoms and neuropathological alterations in a murine model of Alzheimer s disease Calcagnini S, Bedse G, Lavecchia AM, Caruso A, Scaccianoce S, de Ceglia M, Gallelli CA, Romano A, Cassano T and Gaetani S.
47. 21st Seminar of the Italian Society of Pharmacology, Bresso, September 2018. Effects of subdiaphragmatic deafferentation on oleoylethanolamide induced fos expression in the brain M. de Ceglia, J.B. Koczwara, C.A. Gallelli, E.K. Azari, M. Arnold, A. Romano and S. Gaetani.
48. National Congress for PhD students in Neuroscience organized from the Italian Society of Neuroscience, Napoli, March 2019 Effects of oleoylethanolamide on the brain circumventricular organs: novel insights on OEA anti-obesity effects M.Friuli, M. de Ceglia, C.A. Gallelli, J.B. Koczwara, A. Romano, Giulio G. Muccioli and S. Gaetani.
49. National Congress for PhD students in Neuroscience organized from the Italian Society of Neuroscience, Napoli, March 2019 Depression and anxiety as obesity-related comorbidities: possible protective effects of acylethanolamides M. de Ceglia, A. Romano, M. V. Micioni Di Bonaventura, M. E. Giusepponi, C. A. Gallelli, J. B. Koczwara, E. Micioni Di Bonaventura, T. Cassano, C. Cifani, S. Gaetani.
50. 46th Congress of the European Calcified Tissue Society (ECTS), Budapest, May 2019 Oxytocinincrease in bone, soleus muscle and hypothalamic paraventricular nuclei regulates the response to cold stress in mice exerting phenotype-dependent protective effects towards slow-twitch muscle C. Camerino, E. Conte, A. Romano, M. de Ceglia, M. R. Carratù, S. Gaetani, D. Tricarico.
51. 7th Conference of the Mediterranean Neuroscience Society (MNS), Marrakech, June 2019 The selective inhibition of FAAH ameliorates cognitive decline, depressive-like symptoms and neuropathological alterations in a murine model of Alzheimer s disease T. Cassano, S. Calcagnini, G. Bedse, M. Lavecchia, A. Caruso, S. Scaccianoce, M. de Ceglia, C. A. Gallelli, M. Friuli, A. Romano, S. Gaetani.
52. 39° National congress of the Italian Society of Pharmacology, Firenze, November 2019 Effects of oleoylethanolamide on the brain circumventricular organs: novel insights on OEA anti-obesity effects A. Romano, M.Friuli, M. de Ceglia, C.A. Gallelli, J.B. Koczwara, M.V. Micioni Di Bonaventura, C. Cifani, Giulio G. Muccioli and S. Gaetani.
53. 39° National congress of the Italian Society of Pharmacology, Firenze, November 2019 Chronic inhibition of fatty acid amide hydrolase. the Alzheimer-like phenotype in 3×Tg-AD mice T. Cassano, S. Calcagnini, G. Bedse, M. Lavecchia, A. Caruso, S. Scaccianoce, M. de Ceglia, C. A. Gallelli, M. Friuli, A. Romano, Silvana Gaetani.
54. 39° National congress of the Italian Society of Pharmacology, Firenze, November 2019 Depression and anxiety as obesity-related comorbidities: possible protective effects of acylethanolamides . M. Friuli, A. Romano, M.V. Micioni Di Bonaventura, M. E. Giusepponi, M. de Ceglia, C. A. Gallelli, J. B. Koczwara, E. Micioni Di Bonaventura, T. Cassano, C. Cifani and S. Gaetani.
55. 39° National congress of the Italian Society of Pharmacology, Firenze, November 2019 Oxytocinincrease in bone, soleus muscle and hypothalamic paraventricular nuclei regulates the response to cold stress in mice exerting phenotype-dependent protective effects towards slow-twitch muscle C. Camerino, E. Conte, A. Romano, M. de Ceglia, M. R. Carratù, S. Gaetani, D. Tricarico.
56. 39° National congress of the Italian Society of Pharmacology, Firenze, November 2019 Long exposure to high palatable food on pain sensitivity: role of cannabinergic system C. Avagliano, M.V. Micioni Di Bonaventura, M. E. Giusepponi, C. De Caro, C. Cristiano, G. La Rana, A. Romano, A. Calignano, S. Gaetani, R. Russo, C. Cifani.
57. XX Annual meeting of the Sociedad Española de Investigación sobre Cannabinoides (SEIC), Barcelona, November 2019 Depression and anxiety as obesity-related comorbidities: possible protective effects of acylethanolamides M. de Ceglia, A. Romano, M. Friuli, M. V. Micioni Di Bonaventura, M. E. Giusepponi, C. A. Gallelli, J. B. Koczwara, A. L. Gavito, E. Micioni Di Bonaventura, T. Cassano, F. Rodriguez de Fonseca, C. Cifani and S. Gaetani
58. 40° National congress of the Italian Society of Pharmacology Digital Edition 2021 Pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) reduces depressive-like and anxiety-like behaviours induced by the abstinence from a high-caloric-highpalatable diet causing obesity . Marialuisa de Ceglia, Adele Romano, Marzia Friuli, Maria Vittoria Micioni Di Bonaventura, Maria Elena Giusepponi, Cristina Anna Gallelli, Justyna Barbara Koczwara, Ana Luisa Gavito, Emanuela Micioni Di Bonaventura, Tommaso Cassano, Fernando Rodriguez de Fonseca, Carlo Cifani and Silvana Gaetani.
59. 40° National congress of the Italian Society of Pharmacology Digital Edition 2021 Involvement of the central oxytocinergic system in aberrant food intake: possible effects of acylethanolamides . M. Friuli, A. Romano, M.V. Micioni Di Bonaventura, M.E. Giusepponi, M. de Ceglia, C.A. Gallelli, J.B. Koczwara, E. Micioni Di Bonaventura, T. Cassano, C. Cifani and S. Gaetani.
60. 19th National Congress of the Italian Society for Neuroscience Digital Edition Effects of oleoylethanolamide in a pre-clinical rodent model of diet-induced obesity: from the modulation of eating and metabolism to neuroprotective properties . B. Eramo, A. Romano, M. Friuli, M. de Ceglia, C.A. Gallelli, J.B. Koczwara, M.V. Micioni di Bonaventura, C. Cifani and S. Gaetani.
61. 19th National Congress of the Italian Society for Neuroscience Digital Edition Deranged central oxytocinergic signaling in pre-clinical models of hedonic feeding . Marzia Friuli, Barbara Eramo, Maria Vittoria Micioni Di Bonaventura, Emanuela Micioni Di Bonaventura, Carlo Cifani, Silvana Gaetani and Adele Romano.
62. 8th International Conference of the Mediterranean Neuroscience Society (MNS), Dubrovnik, Croatia, May 2022-Poster Presentation Deranged central oxytocinergic signaling in pre-clinical models of obesity and hedonic feeding B. Eramo, M. Friuli, M. V. Micioni Di Bonaventura, E. Micioni Di Bonaventura, C. Cifani, S. Gaetani and A. Romano.
63. 41° National congress of the Italian Society of Pharmacology, Rome, November 2022-Poster Presentation Oleoylethanolamide affects the acylethanolamides profiles in selected brain areas after acute systemic administration . Eramo B., Friuli M., Zahid N., Gallelli C.A., Muccioli G.G., Romano A. and Gaetani S.
64. 41° National congress of the Italian Society of Pharmacology, Rome, November 2022 Oleoylethanolamide reduces hepatic oxidative stress and endoplasmic reticulum stress in high-fat diet-fed rats . Marzia Friuli, Adele Romano, Barbara Eramo, Zahid Nisha, Justyna Barbara Koczwara, Anna Maria Giudetti, and Silvana Gaetani.
65. 41° National congress of the Italian Society of Pharmacology, Rome, November 2022 "Anti-inflammatory and neuroprotective effects of oleoylethanolamide in a rat model of diet-induced obesity" N. Zahid, M. Friuli, B. Eramo, S. Gaetani and A. Romano
66. XXV Conference of Young SIF Pharmacologists, Urbino, September 2023 "Unrevealing the role of the neuropeptide oxytocin in anorexia nervosa: a preclinical investigation". Barbara Eramo, Adele Romano, Silvana Gaetani and Ida Nilsson.
67. 20th National Congress of the Italian Society for Neuroscience, Torino, September 2023 Unrevealing the role of the neuropeptide oxytocin in anorexia nervosa: a preclinical investigation". Barbara Eramo, Adele Romano, Silvana Gaetani and Ida Nilsson.
68. WCP 2023 World congress of basic and clinical pharmacology, Glasgow July 2023. To brain or not to brain : evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system Romano A., Friuli M., Eramo B., Gallelli C.A., Koczwara J.K., Paquot A., Muccioli G., Lutz T.A., Gaetani S.

Press/Media release on the scientific achievement
Press release by Sapienza University of Rome, A New Ally for Binge Eating Disorder
(https://www.uniroma1.it/en/notizia/new-ally-binge-eating-disorder); Secolo d Italia Ecco il farmaco anti-abbuffata, blocca la fame compulsiva, combatte l obesità: un orgoglio tutto italiano (https://www.secoloditalia.it/2020/05/ecco-il-farmaco-anti-abbuffata-bloc...); Sir Agenzia d informazione Salute: Università Sapienza Roma e Camerino, scoperta molecola che contrasta il disturbo da alimentazione incontrollata (https://www.agensir.it/quotidiano/2020/5/12/salute-universita-sapienza-r...); Mela Rossa Binge eating disorder: una molecola potrebbe tenere sotto controllo questo disturbo alimentare (https://www.melarossa.it/salute/patologie/binge-eating-disorder-identifi...); Nutri e Previeni Disturbi alimentari: per prevenire il binge eating forse una molecola (http://www.nutrieprevieni.it/disturbi-alimentari-per-prevenire-il-binge-...); Il fatto alimentare Disturbi alimentari: una possibile nuova arma contro il binge eating. Lo studio dei ricercatori italiani (https://ilfattoalimentare.it/binge-eating-possibile-farmaco.html); Quotidiano Sanità Una molecola contro le abbuffate. L hanno scoperta i team di ricerca della Sapienza e Camerino (http://www.quotidianosanita.it/scienza-e-farmaci/articolo.php?articolo_i...); Repubblica Il cibo è piacere, non ossessione: una molecola ci salverà dalle abbuffate (https://rep.repubblica.it/pwa/weekend/2020/05/21/news/il_mangiare_e_un_p... la_ci_salvera_dalle_abbuffate-257134407/); Leggo Abbuffate da stress, individuata la molecola in grado di bloccarle: lo studio dei ricercatori della Sapienza e di Camerino (https://www.leggo.it/sanita/abbuffate_da_stress_molecola_bloccarle_studi...); Il Mattino Abbuffate da stress, individuata la molecola in grado di bloccarle: lo studio dei ricercatori della Sapienza e di Camerino (https://www.ilmattino.it/primopiano/sanita/abbuffate_da_stress_molecola_... _camerino-5229973.html); Quotidiano di Puglia Abbuffate, adesso basta Una molecola ci salverà (https://www.quotidianodipuglia.it/attualita/abbuffate_adesso_basta_una_m...); Fidest Contrastare il disturbo dell alimentazione incontrollata (https://fidest.wordpress.com/2020/05/16/contrastareil-disturbo-dellalime...); ohga! "Alimentazione compulsiva e incontrollabile: un molecola può aiutare a contrastarla" (https://www.ohga.it/alimentazione-compulsiva-e-incontrollabile-un-moleco...)