Catalogo dei Corsi di studio

Curriculum vitae Prof. Rita Businaro
Education
Classical High School Diploma
Degree in Biological Sciences cum laude, Sapienza University
Degree in Medicine and Surgery cum laude Sapienza University
Specialization in General Pathology cum laude SapienzaUniversity
Post-doc course in Immunology at the Institute of Medical Research, Camden, NJ, USA

Position title
Professor and Chair of Human Anatomy.
Director of II level Master in Stress, Sport, Nutrition: New Diagnostic And Therapeutic Approaches For Wellness, Fitness, Prevention And Rehabilitation , Faculty of Pharmacy and Medicine, Sapienza University of Rome
Vice-President of AIF (Italian Fulbright Association)
Vice-president of the Bachelor s Degree in Technical medical radiology for images and radiotherapy at the School of Medicine, Sapienza University of Rome.
Head of the Neuromorphology Laboratory, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome

A. Positions and Honors
Previous positions held:
2001-2020 Associate Professor Human Anatomy Sapienza University
1985-2000 Assistant Professor Human Anatomy Sapienza University
1982-85 Associate Scientist Laboratory of Cell Biology, CNR, Rome
1980-81 Associate Scientist Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA
1978-80 Fellow, Laboratory of Cell Biology, CNR, Rome

HONORS
1985 Adelaide Ristori International Award, directed to worldwide women excelling in scientific and artistic fields
2011,2015 Invited Speaker at the international School of Neuroimmunopharmacology, University of Insubria, Varese
Member of PhD School in "EXPERIMENTAL MEDICINE", curriculum Innovative Technologies in Translational Medicine, cycle XXVII, XXVIII, XXIX
Member of the doctoral commission "EXPERIMENTAL MEDICINE", XXXVI cycle
Thesis Director for Sapienza University PhD in Italy-France Cycle XXX
Invited speaker: PhD School in Clinical and Experimental Pharmacology, University of Insubria
Supervisor of Executive Protocol of Framework Agreement with Rutgers University, New Brunswick / Piscataway, USA
Coordinator of the Erasmus program between Université d'Artois, France; University of Marburg (Germany),; University of Gothenburg (Sweden) and Sapienza University, Rome
Visiting professor at Rutgers University, New Jersey USA
Visiting professor at the Université d Artois, France
Member EAS (European Atherosclerosis Society)
Member ISNIM (International Society for NeuroimmunoModulation)
Member of the New York Academy of Sciences

REFEREE for the following journals:

Neuroscience & Biobehavioral Reviews IF 10,24
Molecular Cell Research IF 6.9
Journal of Neuroimmune Pharmacology IF 4.212
Neuroscience IF 3.6
Journal of Neural Transmission IF 2.9
Journal of Diabetes and its complications IF 1.5

REFEREE for CINECA

Associate-Editor for Journal of Alzheimer s Disease
Member of the Editorial Board www.brainimmune.com
Member of the editorial Board Journal of Pharmacovigilance

Member of the European Atherosclerois Society (EAS)
Member of the International Society of NeuroImmunoModulation (ISNIM)
Member of the New York Academy of Sciences

Main research topics
-Study of comorbidity of Alzheimer's disease and cerebrovascular disorders: a multidisciplinary approach to identify cellular proteins and the mechanisms involved in the accumulation of amyloid aggregates in the central nervous system. Role of the diet
-Nutraceuticals with anti-inflammatory activity
-Alzheimer's disease and the endocannabinoid system
-Role of the cell populations and mediators of the immune response in the etiopathogenesis of atherosclerosis
-Cross-talk Central Nervous System-Immune System

Funding
2021 International Research Contract Milmed, Sweden PI
2021 Ateneo Role of endocannabinoid modulation in autophagy and inflammatory mechanisms underlying Alzheimer s disease PI
2020 Ateneo FAAH targeting and endocannabinoids: impact on Alzheimer's disease PI
BRIC 2019 Innovative aspects in the assessment of hyperbaric risk in work contexts: multifactorial assessment of oxidative stress as an estimate of decompression stress in hyperbaric atmospheres. PI Unit 6
2019 International agreements Prot. AI2619L3JS macrophage-released microvesicles and lung fibrosis PI
2018 International research contract with Milmed, Sweden
2018 Ateneo Non-pharmacological treatment of Alzheimer disease: the diet impact PI
2017 International agreements Prot. AI2617CJBB Impact of a pro-inflammatory microenvironment on adipose tissue derived stromal cells: possible impairment of their regenerative properties
BRIC 2016 Study of a multifactorial model for the prevention of hyperbaric risk that integrates individual and occupational risk factors.
2016 International agreements Prot. AI261692TA Inflammatory mechanisms of ozone toxicity: potential activation of macrophages PI
2016 Ateneo prot. RM116154CCE6BAE7 NPY, stress hormone, modulates inflammatory processes unferlying atherosclerosis progression PI
2016 International research contract with Milmed, Sweden PI
2015 International agreements prot. AI2615BE38 Macrophage pro-inflammatory activity in tissue injury. PI
2015 PRIN Prot. 2015KMMKBN Endocannabinoid Signaling in Alzheimer's Disease: A Novel Target for Mechanistic Understanding and Potential Therapeutics PI Sapienza Unit
2015 Ateneo prot.C26A15FHES Anti-inflammatory activity of polyphenolic compounds in chronic degenerative diseases PI
2014 Ateneo Prot. C26A14M7PS Hierarchical role of cytokine classes in chronic inflammatory diseases: IL-23-Il-17 axis in PI atherosclerotic pathology

2014 Acquisition of medium and large equipment: Prot.C26G142PSY Advanced microscopy with high resolution confocal video system for the understanding of complex pathophysiological mechanisms PI
2013 Ateneo Prot C26A13CT5H Cytokines and neuromediators involved in inflammatory processes associated with degenerative and developmental pathologies PI
2013 Acquisition of medium and large equipment Prot C26G13WLNT Set up of a biological containment laboratory P2 for the genetic manipulation of prokaryotic and eukaryotic cells for biomedical and translational applications Research participant
2012 FARI prot. C26I12KKHK PI

Selected peer-reviewed publications

Author of 150 publications, H-index 24, i10-index 55, citations 2023

Grieco M, De Caris MG, Maggi E, Armeli F, Coccurello R, Bisogno T, D'Erme M, Maccarrone M, Mancini P, Businaro R. Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization. Int J Mol Sci. 2021;22:7711 IF 4.556
Armeli F., Bonucci A., Maggi E., Pinto A., Businaro R. Mediterranean diet and neurodegenerative diseases: the neglected role of nutrition in the modulation of endocannabinoid system. Biomolecules 2021; 11: 790 IF 4.57
Businaro R., Vauzour D., Sarris J., Munch G., Gyengesi E., Brogelli L., Zuzarte P. Therapeutic opportunities for food supplements in neurodegenerative diseases and depression. Front Nutrition 2021; 8:669846 IF 5.87
Fusconi M, Candelori F, Weiss L, Riccio A, Priori R, Businaro R, Mastromanno L, Musy I, de Vincentiis M, Greco A. Qualitative mucin disorders in patients with primary Sjögren's syndrome: a literature review. Med Oral Patol Oral Cir Bucal. 2021;26:e71-e77. IF 1.716
Corbo RM, Businaro R, Scarabino D. Leukocyte telomere length and plasma interleukin-1 and interleukin-18 levels in mild cognitive impairment and Alzheimer's disease: new biomarkers for diagnosis and disease progression? Neural Regen Res. 2021;16:1397-1398 IF3.171
Malaviya R, Kipen HM, Businaro R, Laskin JD, Laskin DL. Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms. Toxicol Appl Pharmacol. 2020;409:115272 IF 3.347
Fusconi M, Musy I, Valente D, Maggi E, Priori R, Pecorella I, Mastromanno L, Di Cristofano C, Greco A, Armeli F, Candelori F, de Vincentiis M, Gallo A, Businaro R. Immunohistochemical detection of IL-17 and IL-23 improves the identification of patients with a possible diagnosis of Sjogren's syndrome. Pathol Res Pract. 2020;216:153137 IF 2.05
Businaro R, Maggi E, Armeli F, Murray A, Laskin DL. Nutraceuticals as potential therapeutics for vesicant-induced pulmonary fibrosis. Ann N Y Acad Sci. 2020 IF 4.728
De Caris MG, Grieco M, Maggi E, Francioso A, Armeli F, Mosca L, Pinto A, D'Erme M, Mancini P, Businaro R. Blueberry Counteracts BV-2 Microglia Morphological and Functional Switch after LPS Challenge. Nutrients. 2020;12:1830 IF 5.43
Scarabino D, Peconi M, Broggio E, Gambina G, Maggi E, Armeli F, Mantuano E, Morello M, Corbo RM ,Businaro R. Relationship between proinflammatory cytokines (Il-1beta, Il-18) and leukocyte telomere length in mild cognitive impairment and Alzheimer's disease. Exp Gerontol. 2020;136:110945 IF 3.376
Angeloni C, Businaro R, Vauzour D. The role of diet in preventing and reducing cognitive decline [published online ahead of print, 2020 Mar 5]. Curr Opin Psychiatry. 2020;10.1097/YCO.0000000000000605 IF 4.392
Versele R, Corsi M, Fuso A, Sevin E, Businaro R, Gosselet F, Fenart L, Candela P. Ketone Bodies Promote Amyloid- 1-40Clearance in a Human in Vitro Blood-Brain Barrier Model. Int J Mol Sci. 2020;21:934 IF 4.556
Sobolev AP, Ciampa A, Ingallina C, Mannina L, Capitani D, Ernesti I, Maggi E,
Businaro R, Del Ben M, Engel P, Giusti AM, Donini LM, Pinto A. Blueberry-Based
Meals for Obese Patients with Metabolic Syndrome: A Multidisciplinary Metabolomic
Pilot Study. Metabolites. 2019;9 IF3.3
Businaro R, Scaccia E, Bordin A, Pagano F, Corsi M, Siciliano C, Capoano R, Procaccini E, Salvati B,Vietri MT, Frati G, De Falco E.Platelet lysate-derived neuropeptide Y influences migration and angiogenesis of human adipose tissue-derived stromal cells In Press IF 4.609
Pinto A, Bonucci A, Maggi E, Corsi M, Businaro R. Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Disease. Antioxidants (Basel). 2018;7(5).pii: E63. IF 4.5
Profumo E, Buttari B, Tinaburri L, D'Arcangelo D, Sorice M, Capozzi A, Garofalo T, Facchiano A, Businaro R, Kumar P, Singh B,Parmar VS, Saso L., Riganò R.Oxidative Stress Induces HSP90 Up-Regulation on the Surface of Primary Human Endothelial Cells: Role of the Antioxidant 7,8-Dihydroxy-4-Methylcoumarin to Prevent HSP90 Exposure to the Immune System. Oxidative Medicine and Cellular Longevity. 2018; 2018:2373167 IF 4.593
Capoano R, Businaro R, Tesori MC, Donello C, Lombardo F, Lo Vasco VR, Capriotti L, Corsi M, Di Raimo T, Leopizzi M, Salvati B, Ricci S. Wounds Difficult to Heal: An Effective Treatment Strategy. Curr Vasc Pharmacol.2017;15:582-588 IF 2.102
Rengo M, Bellini D, Businaro R, Caruso D, Azzara G, De Santis D, Picchia S, Biondi T, Eid M, Boschiero D, Laghi A. MDCT of the liver in obese patients:evaluation of a different method to optimize iodine dose. Abdom Radiol (NY). 2017; 42:2420-2427 IF 2.189
Businaro R, Corsi M, Asprino R, Di Lorenzo C, Laskin D, Corbo RM, Ricci S, Pinto A. Modulation Of Inflammation As A Way Of Delaying Alzheimer's Disease Progression: The Diet's Role. Curr Alzheimer Res. 2017; 15:363-380 IF 3.498
Di Raimo T, Leopizzi M, Mangino G, Rocca CD, Businaro R, Longo L, Lo Vasco VR. Different expression and subcellular localization of Phosphoinositide-specific Phospholipase C enzymes in differently polarized macrophages. J Cell Commun Signal. 2016;10:283-293 IF 3.123
Businaro R, Corsi M, Di Raimo T, Marasco S, Laskin DL, Salvati B, Capoano R, Ricci S, Siciliano C, Frati G, De Falco E. Multidisciplinary approaches to stimulate wound healing. Ann N Y Acad Sci. 2016;1378:137-142 IF 4.383
Malaviya R, Sunil VR, Venosa A, Vayas KN, Businaro R, Heck DE, Laskin JD, Laskin DL. Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants. Ann N Y Acad Sci. 2016;1374:168-75 IF 4.383
Businaro R, Corsi M, Azzara G, Di Raimo T, Laviola G, Romano E, Ricci L, Maccarrone M, Aronica E, Fuso A, Ricci S. Interleukin-18 modulation in autism spectrum disorders. J Neuroinflammation. 2016;13:2. IF 5.366
Corsi M, Di Raimo T, Di Lorenzo C, Rapp-Ricciardi M, Archer T, Ricci S, Businaro R. Cognitive disability in Alzheimer's disease and its management. Clin Ter. 2016;167:e123-e126. IF 2.925
Lo Vasco VR, Leopizzi M, Puggioni C, Della Rocca C, Businaro R. Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells. Mol Cell Biochem. 2014;394:43-52 IF 2.388
Buttari B, Profumo E, Segoni L, D'Arcangelo D, Rossi S, Facchiano F, Saso L, Businaro R, Iuliano L, Riganò R. Resveratrol counteracts inflammation in human M1 and M2 macrophages upon challenge with 7-oxo-cholesterol: potential therapeutic implications in atherosclerosis. Oxid Med Cell Longev. 2014;2014:257543 IF 3.363
Buttari B, Profumo E, Domenici G, Tagliani A, Ippoliti F, Bonini S, Businaro R, Elenkov I, Riganò R. Neuropeptide Y induces potent migration of human immature dendritic cells and promotes a Th2 polarization. FASEB J. 2014;28:3038-49. IF 5.49
Lo Vasco VR, Leopizzi M, Puggioni C, Della Rocca C, Businaro R. Fibroblast growth factor acts upon the transcription of phospholipase C genes in human umbilical vein endothelial cells. Mol Cell Biochem. 2014;388(1-2):51-9. IF 2.33
Lo Vasco VR, Leopizzi M, Puggioni C, Della Rocca C, Businaro R. Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells. Mol Cell Biochem. 2014;394:43-52 IF 3.396
Buttari B, Segoni L, Profumo E, D'Arcangelo D, Rossi S, Facchiano F, Businaro R, Iuliano L, Riganò R. 7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages. Biochem Pharmacol. 2013;86:130-7 IF 5.858
Gabriele L, Schiavoni G, Mattei F, Sanchez M, Sestili P, Butteroni C, Businaro R, Mirchandani A, Niedbala W, Liew FY, Afferni C. Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen. J Allergy Clin Immunol. 2013;132:686-695.e7
IF 14.11
Ricci S, Businaro R, Ippoliti F, Lo Vasco VR, Massoni F, Onofri E, Troili GM, Pontecorvi V, Morelli M, Rapp Ricciardi M, Archer T. Altered cytokine and BDNF levels in autism spectrum disorder. Neurotox Res. 2013;24:491-501 IF 3.54
Ippoliti F, Canitano N, Businaro R. Stress and obesity as risk factors in cardiovascular diseases: a neuroimmune perspective. J Neuroimmune Pharmacol. 2013;8:212-26 IF 4.147
Businaro R. Neuroimmunology of the atherosclerotic plaque: a morphological approach. J Neuroimmune Pharmacol. 2013;8:15-27 IF 4.147
Businaro R, Tagliani A, Buttari B, Profumo E, Ippoliti F, Di Cristofano C, Capoano R, Salvati B, Riganò R. Cellular and molecular players in the atherosclerotic plaque progression. Ann N Y Acad Sci. 2012;1262:134-41 IF 4.728
Businaro R, Ippoliti F, Ricci S, Canitano N, Fuso A. Alzheimer's disease promotion by obesity: induced mechanisms-molecular links and perspectives. Curr Gerontol Geriatr Res. 2012;2012:986823 IF 3.12
Ricci S, Fuso A, Ippoliti F, Businaro R. Stress-induced cytokines and neuronal dysfunction in Alzheimer's disease. J Alzheimers Dis. 2012;28:11-24 IF 4.472
Lo Vasco VR, Salmaso R, Zanardo V, Businaro R, Visentin S, Trevisanuto D, Cosmi E. Fetal aorta wall inflammation in ultrasound-detected aortic intima/media thickness and growth retardation. J Reprod Immunol. 2011;91):103-7. IF 4.018
Lo Vasco VR, Pacini L, Di Raimo T, D'arcangelo D, Businaro R. Expression of phosphoinositide-specific phospholipase C isoforms in human umbilical vein endothelial cells. J Clin Pathol. 2011;64:911-5 IF 2.974
Buttari B, Profumo E, Di Cristofano C, Pietraforte D, Lionetti V, Capoano R,
Salvati B, Businaro R, Di Giammarco G, Riganò R.
Haemoglobin triggers chemotaxis of human monocyte-derived dendritic cells: possible role in atherosclerotic lesion instability.
Atherosclerosis. 2011;215(2):316-22.
Businaro R, Leone S, Fabrizi C, Sorci G, Donato R, Lauro GM, Fumagalli L. S100B protects LAN-5 neuroblastoma cells against Abeta amyloid-induced neurotoxicity via RAGE engagement at low doses but increases Abeta amyloid neurotoxicity at high doses. J Neurosci Res. 2006; 83:897-906 IF 4.164
Businaro R, Fabrizi C, Caronti B, Calderaro C, Fumagalli L, Lauro GM. Myelin basic protein induces heme oxygenase-1 in human astroglial cells. Glia. 2002;37:83-8 IF 7.45
Fabrizi C, Businaro R, Lauro GM, Fumagalli L. Role of alpha2-macroglobulin in regulating amyloid beta-protein neurotoxicity: protective or detrimental factor? J Neurochem. 2001; 78:406-12 IF 5.372
Fabrizi C, Businaro R, Lauro GM, Starace G, Fumagalli L. Activated alpha2macroglobulin increases beta-amyloid (25-35)-induced toxicity in LAN5 human neuroblastoma cells. Exp Neurol. 1999;155:252-9 IF 5.33
Businaro R, Fabrizi C, Persichini T, Starace G, Ennas MG, Fumagalli L, Lauro GM. Modulation of the alpha 2 macroglobulin receptor/low density lipoprotein receptor related protein by interferon-gamma in human astroglial cells. J Neuroimmunol. 1997;72(1):75-81