Catalogo dei Corsi di studio

CLAUDIA GIAMPIETRI
Curriculum Vitae
Place: Rome
Date: March, 2021

Part I General Information

Full Name Claudia Giampietri
Citizenship Italian
E-mail claudia.giampietri@uniroma1.it
Spoken Languages Italian, English

Part II Education

Type Year Institution Notes (Degree,..Experience, )
University 1991 Cambridge University First Certificate in English (A)
University graduation 1996 Sapienza University Degree in Scienze Biologiche
Post-graduate studies 1996-99 IDI-IRCCS, Rome Fellowships in vascular biology
Visiting scientist 1999 Thomas Jefferson University Prof E. Alnemri Laboratory
Middle school Professorship 2001 MIUR Science teacher in middle schools
PhD 2003 Sapienza University, Rome Scienze e Tecnologie Cellulari
Assegni di ricerca 2004-09; 2012-14 Sapienza University, Rome Supervisor Prof. E. Ziparo
Post-doc fellowship 2009-11 Sapienza University, Rome Supervisor Prof. E. Ziparo
High school Professorship 2013 MIUR Science teacher in high schools
National Scientific Qualification 2014 MIUR Human Anatomy Associate Professor

Part III Appointments

IIIA Academic Appointments

Start End Institution Position
2016 2019 Sapienza University, Rome RTD-B Bio/16
2017 on Sapienza University, Rome Member of Academic Board, PhD program in Morphogenesis Tissue Engineering
2019 on Sapienza University, Rome Human Anatomy Associate Professor
2019 on Sapienza University, Rome RAM (academic manager of international mobility in the pharmaceutical area)

IIIB Other Appointments

Start End Institution Position
2001 2013 MIUR Science teacher in middle schools
2013 2016 MIUR Science teacher in high schools

Part IV Teaching experience

2009 2017 Sapienza University, Rome Teaching of Histology at C.d.L Logopedia A in Professioni Sanitarie della Riabilitazione della Facoltà di Medicina e Odontoiatria; Histology at C.d.L. in Tecniche Audiometriche della Facoltà di Medicina e Odontoiatria
2015 on Sapienza University, Rome Teaching of Human Anatomy at Corso di Laurea delle Professioni Sanitarie in Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare - Facoltà di Medicina e Odontoiatria
2017 on Sapienza University, Rome Teaching of Human Anatomy at Corso di Laurea in Dietistica- Facoltà di Farmacia e Medicina, Medicina e Odontoiatria
2017 on Sapienza University, Rome Teaching of Human Anatomy at Corso di Laurea in Scienze Farmaceutiche Applicate, Facoltà di Farmacia e Medicina
2017 on Sapienza University, Rome Teaching of Human Anatomy at Corso di Laurea in Tecniche della prevenzione nell'ambiente e nei luoghi di lavoro (abilitante alla professione sanitaria di Tecnico della prevenzione nell'ambiente e nei luoghi di lavoro) - Facoltà di Medicina e Odontoiatria-polo di Rieti
2015 on Sapienza University, Rome Supplementary teaching activity of Human Anatomy:
- Corso di laurea in Medicina e Chirurgia C - Facoltà di Medicina e Odontoiatria;
- Corso di laurea in Medicina e Chirurgia A - Facoltà di Medicina e Odontoiatria
- Corso di laurea in Tecniche di Laboratorio Biomedico A - Facoltà di Medicina e Odontoiatria;
-Corso di laurea in Biotecnologie - Facoltà di Farmacia e Medicina;
-Corso di laurea in Scienze della moda e del costume;
-Corso di laurea in Ingegneria Clinica;
-Corso di laurea di laurea Infermieristica A - Facoltà di Medicina e Odontoiatria, Università Sapienza, Roma
2009 on Sapienza University, Rome Member of exam commissions in the following Corsi di laurea: Logopedia A and Tecniche Audiometriche (Histology exams); Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare, Dietistica, Scienze Farmaceutiche Applicate, Infermieristica A, Tecniche della prevenzione nell'ambiente e nei luoghi di lavoro, Tecniche di Laboratorio Biomedico, Biotecnologie, Ingegneria Clinica (Human Anatomy exams)

Part V - Society and association
memberberships, Awards and Honors

Year Title
1999-on Member of Italian National Board of Biologists
1998 Nato short fellowship for international conference attendance

Part VI - Funding Information [grants as PI-principal investigator]

Year Title Founding body Grant value
2017 FFABR grant (PI) MIUR 3000 euros
2018 c-Flip role in cell death, survival and autophagy crosstalk grant (PI) Italian-India cooperation grant, Sapienza 7500 euros

Part VII Research Activities

Keywords Brief Description

apoptosis The scientific activity of Dr. Giampietri focuses on molecular mechanisms controlling cell death, proliferation and autophagy in normal and pathological conditions both in humans and in experimental models. More in detail these issues have been addressed in:
a) male and female gonads (particularly fetal and post-natal germ cells);
b) heart;
c) skeletal muscle stem cell compartment;
d) endothelial cells from large vessels;
e) fibroblasts;
f) human cancer cell lines (from melanoma, prostate cancer, hepatocarcinoma).
Dr. Giampietri has contributed to clarify different roles of the well-known anti-apoptotic cellular-Flice Like Inhibitory Protein (c-FLIP) in several in vitro and in vivo models. Dr Giampietri has been involved in the production of a c-FLIP transgenic mouse model and she has identified novel un-expected functions of c-FLIP in autophagy modulation, endoplasmic reticulum stress response and lipid accumulation. Dr Giampietri studies have been carried out through cellular and molecular biology techniques as well as confocal immunofluorescence and immunohistochemistry.

cell death
c-FLIP
proliferation
apoptosis inhibitors
autophagy
cancer

Part VIII Summary of Scientific Achievements

Research Articles
Impact
Factor
1) E1A stimulates FGF-2 release promoting differentiation of primary endothelial cells
C Giampietri, M Levrero, A Felici, A D Alessio, MC Capogrossi, C Gaetano.
Cell Death and Differentiation (2000) 7, 292-301.

2) Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its alpha receptor
F De Marchis, D Ribatti, C Giampietri, A Lentini, D Faraone, M Scoccianti, MC Capogrossi, A Facchiano.
Blood (2002) 99, 2045-2053.

3)"RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells"
MS Aguzzi, C Giampietri, F De Marchis, F Padula, R Gaeta, G Ragone, MC Capogrossi, A Facchiano.
Blood (2004) 103(11), 4180-4187.

4) "The Fas system in the seminiferous epithelium and its possible extra-testicular role"
A Riccioli, L Salvati, A D'Alessio, D Starace, C Giampietri, P De Cesaris, A Filippini, E Ziparo.
Andrologia (2003) 35(1), 64-70. Review.

5)"Characterization of signaling pathways leading to Fas expression induced by TNF- : pivotal role of NF B"
D Starace, A Riccioli, A D'Alessio, C Giampietri, S Petrungaro, R Galli, A Filippini, E Ziparo, P De Cesaris.
FASEB Journal (2005) 19(3),473-5.

6) Flip is expressed in mouse germ cells and protects from apoptosis
C Giampietri, S Petrungaro, P Coluccia, A D Alessio, D Starace, A Riccioli, SM Srinivasula, E Alnemri, F Palombi, A Filippini, E Ziparo, P De Cesaris.
Cell Death and Differentiation (2003) 10(2),175-84.

7)"Germ cell apoptosis control during spermatogenesis"
C Giampietri, S Petrungaro, P Coluccia, A D'Alessio, D Starace, A Riccioli, F Padula, F Palombi, E Ziparo, A Filippini, P De Cesaris.
Contraception (2006) 72, 298-302.

8)"c-Flip expression and function in fetal mouse gonocytes".
C Giampietri, S Petrungaro, F G Klinger, P Coluccia, A Paone, E Vivarelli, A Filippini, P De Cesaris, M De Felici, E Ziparo.
FASEB Journal (2006) 20(1):124-6.

9)"c-FlipL is expressed in undifferentiated mouse male germ cells".
C Giampietri, S Petrungaro, P Coluccia, F Antonangeli, A Paone, F Padula, P De Cesaris, E Ziparo, A Filippini.
FEBS letters (2006) 580(26), 6109-14.

10)"c-Flip over-expression reduces cardiac hypertrophy in response to pressure overload"
C Giampietri, S Petrungaro, M Musumeci, P Coluccia, F Antonangeli, P De Cesaris, A Filippini, G Marano, E Ziparo.
Journal of Hypertension (2008) 26(5), 1008-16.

11) Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-FLIP(L)
F Antonangeli, S Petrungaro S, P Coluccia, Filippini A, E Ziparo, C Giampietri.
Fertility and Sterility (2010) 93(5),1407-14.

12)"Expression profile of a 400 bp Stra8 promoter region during spermatogenesis
F Antonangeli, C Giampietri, S Petrungaro, A Filippini, E Ziparo.
Microscopy Research and Technique (2009) 72(11), 816-22.

13)"Thrombin-mediated impairment of fibroblast growth factor-2 activity
P Totta, R De Cristofaro, C Giampietri, MS Aguzzi, D Faraone, MC Capogrossi, A Facchiano.
FEBS J. (2009) 276 (12), 3277-89.

14) Intracellular targets of RGDS peptide in melanoma cells
MS Aguzzi, P Fortugno, C Giampietri, G Ragone, M C Capogrossi, A Facchiano.
Mol Cancer. (2010) 22, 9-84.

15) c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging
C Giampietri, S Petrungaro, P Coluccia, F Antonangeli, K Giannakakis, T Faraggiana, A Filippini,G Cossu, E Ziparo.
Cell Death & Disease 2010 Apr 29;1:e38. doi: 10.1038/cddis.2010.17.

16) Plasma membrane micro domains regulate TACE-dependent TNFR1 shedding in human endothelial cells.
A D'Alessio, B Esposito, C Giampietri , E Ziparo, JS Pober, A Filippini.
J Cell Mol Med. 2011 Jun 7.

17) RAM, an RGDS analog, exerts potent anti-melanoma effects in vitro and in vivo.
MS Aguzzi, D D'Arcangelo, C Giampietri , MC Capogrossi, A Facchiano.
PLoS One. 2011;6(10): e25352.

18) Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis.
C Giampietri, S Petrungaro, F Padula, A D'Alessio, ES Marini, A Facchiano, A Filippini, E Ziparo.
Apoptosis. 2012 Nov;17(11):1210-22.

19) Therapeutic implications of autophagy modulation in prostate cancer.
C Giampietri, S Petrungaro, A Facchiano, A Filippini, E Ziparo.
J Endocrinol Invest. 2012 Nov;35(10):945.

20) BAMM: a preliminary bibliometric analysis on melanoma manuscripts.
D D'Arcangelo*, C Giampietri *, F Facchiano, A Facchiano.
* equally contributing Authors
Pigment Cell Melanoma Res. 2013 May;26(3):415-7.

21) Sex-related differences in death control of somatic cells.
C Giampietri, S Petrungaro, A Filippini, E Ziparo.
J Cell Mol Med. 2013 Apr;17(4):550-1.

22) Autophagy in prostate cancer and androgen suppression therapy.
E Ziparo, S Petrungaro, ES Marini, D Starace, S Conti, A Facchiano, A Filippini, C Giampietri.
Int J Mol Sci. 2013 Jun 6;14(6):12090-106.

23) Identification of serum regression signs in infantile hemangioma .
D D'Arcangelo, EM Nicodemi, S Rossi, C Giampietri, F Facchiano, A Facchiano.
PLoS One. 2014 Mar 5;9(3):e88545.

24) Necroptosis: molecular signalling and translational implications .
C Giampietri, D Starace, S Petrungaro, A Filippini, E Ziparo.
Int J Cell Biol. 2014;2014:490275.

25) Cell death .
C Giampietri , A Paone, A D'Alessio.
Int J Cell Biol. 2014;2014:864062

26) The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria .
ES Marini, C Giampietri, S Petrungaro, A Filippini, L Scorrano, E Ziparo.
Cell Death & Differentiation 2015 July 22(7): 1131-43

27) c-Flip KO fibroblasts display lipid accumulation associated with endoplasmic reticulum Stress
C Giampietri, S Petrungaro, S Conti, A Facchiano, A Filippini, E Ziparo.
Biochim Biophys Acta-Mol and Cell Biology of Lipids 2015Jul;1851(7):929-36.

28) Cancer microenvironment and endoplasmic reticulum stress response
C Giampietri, S Petrungaro, S Conti, A Facchiano, A Filippini, E Ziparo.
Mediators of Inflammation 2015 Epub 2015 Sept 27

29) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy
D Klionsky, , C Giampietri, et al.
Autophagy 2016 12(1)1-122

30) A novel role of c-FLIP protein in regulation of ER stress response
S Conti, S Petrungaro, ES Marini, S Masciarelli, L Tomaipitinca, A Filippini, C Giampietri, E Ziparo.
Cell Signal 2016 Sept 28 (9):1262-9

31) Lipid storage and autophagy in melanoma cancer stem cells
C Giampietri, S Petrungaro, M Cordella, C Tabolacci, L Tomaipitinca, A Facchiano, A Eramo, A Filippini, F Facchiano, E Ziparo.
Int J. Mol Sci 2017 Jun 15;18(6).

32) Multifaced roles of GSK-3 in cancer and autophagy-related diseases
R Mancinelli, G Carpino, S Petrungaro, CL Mammola, L Tomaipitinca, A Filippini, A Facchiano, E Ziparo, C Giampietri
Oxidative Medicine and Cellular Longevity 2017 December 2nd.

33) WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers
D D Arcangelo, C Giampietri, M Muscio, F Scatozza, F Facchiano, A Facchiano
Oxidative Medicine and Cellular Longevity 2018 December 2nd.

34) Ion Channel Expression in Human Melanoma Samples: In Silico Identification and experimental Validation of Molecular Targets
D D'Arcangelo, F Scatozza , C Giampietri, P Marchetti, F Facchiano, A Facchiano
Cancers. 2019 Mar 29;11(4).

35) Role of autophagy in liver epithelial cells and its impact on systemic homeostasis
L Tomaipitinca, S Mandatori, R Mancinelli, F Giulitti, S Petrungaro, V Moresi, A Facchiano, E Ziparo, E Gaudio, C Giampietri
Nutrients. 2019 Apr 11;11(4).

36) Melanogenesis and autophagy in melanoma
F Scatozza, D D'Arcangelo, C Giampietri, F Facchiano, A Facchiano
Melanoma Research. 2019 May 14.

37) Expression of Genes Related to Lipid Handling and the Obesity Paradox in Melanoma: Database Analysis.
Giampietri C, Tomaipitinca L, Scatozza F, Facchiano A.
JMIR Cancer. 2020 May 19;6(1):e16974. doi: 10.2196/16974

38) Altered Tregs Differentiation and Impaired Autophagy Correlate to Atherosclerotic Disease.
Mandatori S, Pacella I, Marzolla V, Mammi C, Starace D, Padula F, Vitiello L, Armani A, Savoia C, Taurino M, De Zio D, Giampietri C, Piconese S, Cecconi F, Caprio M, Filippini A. Front Immunol. 2020 Mar 13;11:350. doi: 10.3389/fimmu.2020.00350. eCollection 2020

39) The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function.
Montaseri A, Giampietri C, Rossi M, Riccioli A, Del Fattore A, Filippini A. Biomolecules. 2020 Sep 30;10(10):1398. doi: 10.3390/biom10101398

40) Nicotinamide inhibits melanoma in vitro and in vivo.
Scatozza F, Moschella F, D'Arcangelo D, Rossi S, Tabolacci C, Giampietri C, Proietti E, Facchiano F, Facchiano A. J Exp Clin Cancer Res. 2020 Oct 7;39(1):211. doi: 10.1186/s13046-020-01719-3.

41) Anti-tumor effect of oleic acid in hepatocellular carcinoma cell lines via autophagy reduction.
Frontiers in Cell and Developmental Biology
Federico Giulitti, Simonetta Petrungaro, Sara Mandatori, Luana Tomaipitinca, Valerio de Franchis, Antonella D'Amore, Antonio Filippini, Eugenio Gaudio, Elio Ziparo, Claudia Giampietri
Front Cell Dev Biol. 2021 Feb 5;9:629182. doi: 10.3389/fcell.2021.629182. eCollection 2021.

42) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)
D Klionsky, , C Giampietri, et al.
Autophagy. 2021 Feb 8:1-382. doi: 10.1080/15548627.2020.1797280

Total scientific production

Product type Number Data Base Start End
Papers [international] 42 Scopus 2000 2021

Total Impact factor (ISI WOS) 210.534
Medium Impact Factor 5.398
Total Citations (Scopus) 3653
Hirsch (H) index (Scopus) 17