Catalogo dei Corsi di studio

Short Biosketch

Surname: Di Napoli
Name: Arianna
Position: Associate Professor of Pathology
Date of birth: 26/09/1973
Place of birth: Rome, Italy
Citizenship: Italian

Education and Training

From 2020 Qualification as Full Professor in Pathology 06/A4 (ANVUR)
From 2020 Associate Professor of Pathology, Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy
2008-2012 PhD in Immunology, School of Biology and Molecular Medicine, Sapienza University of Rome, Italy
2007-2008 Research Fellow in Molecular Pathology, at the Molecular Laboratory of the Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
2002-2007 Residency in Pathology, II School of Medicine, Sapienza University of Rome, Italy (70/70 cum laude)
1995-2001 School of Medicine, Sapienza University of Rome, Italy (110/110 cum laude)

Research and Professional Experience

Arianna Di Napoli is Associate Professor of Pathology at the Sapienza University of Rome. She is a pathologist and molecular biologist trained at the University of Rome Sapienza (Italy) and at the Harvard Medical School of Boston (USA). Her research is focused on the molecular alterations of lymphomas and solid neoplasms involved in tumor initiation and progression. She is currently investigating the genetic and epigenetic factors that contribute to the development of a newly recognized lymphoma entity associated with the presence of breast implants (i.e. breast implant-associated anaplastic large cell lymphoma; BI-ALCL) authoring 15 related scientific articles. During her research activity, Arianna Di Napoli has gained documented experience in the field of haematopathology and neoplastic pathology of the thyroid, kidney and lung. She has also acquired practical and theoretical knowledge of advanced molecular biology techniques such as next generation sequencing, SNP array, gene expression profiling, Sanger sequencing and, clonality analyses.
She is author of 80 publications, all published in International Journals. She has attended as invited speaker at several international conferences.

Teaching experience

2020-today Doctorate in Philosophy in Translational Medicine and Oncology, Sapienza University of Rome, Italy;
2011-today School of Medicine and Psychology, Sapienza University of Rome, Italy, courses of Fundamental of Surgical Pathology , Pathology of the Mediastinum , Haematopathology ;
2012-2018 Nursing School, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani , Sapienza University of Rome, Italy, Surgical pathology in the integrated course Infermieristica dei processi diagnostico, terapeutici e riabilitativi
2012-today Nursing School, Ospedale Sandro Pertini , RMB, Sapienza University of Rome, Italy, as Coordinator of the integrated course Infermieristica dei processi diagnostico, terapeutici e riabilitativi
2012-2019 Nursing School, Azienda Ospedaliera San Camillo/Forlanini , Sapienza University of Rome, Italy, Surgical pathology in the integrated course Infermieristica dei processi diagnostico, terapeutici e riabilitativi
2011-today Medical Lab Technologist School, Sapienza University of Rome, Italy, Histopathology and correlated techniques
2017-today Graduated School of Pathology, Sapienza University of Rome, Italy, Haematopathology, Pathology of the Mediastinum and of the Lung

Awards
2008 Awarded with a scholarship of the Achille Lattuca Foundation. Roma (Italy)

Membership on Journal Editorial Board and on Professional Medical Societies
Member of the Editorial Board as Academic Editor of Plos One journal
Member of the European Academy of Tumor Immunology (EATI)
Member of the European Bone Marrow Working Group of the European Association of Haematopathology (EAHP)
Member of the Italian Society of Pathology and Cytopathology (SIAPEC)
Member of the Pathology Board of the Italian Lymphoma Foundation (FIL)
Member of the Italian Haemathopathology Group (GIE)
Member of the Lazio Haemathopathology Group (GEL)
Member of the Experts Group on breast implant associated anaplastic large cell lymphoma (BI-ALCL) for the Italian Ministry of Health
Responsible author of the chapter Pediatric nodal marginal zone lymphoma in the WHO Classification of Pediatric Tumors, IARC, Lion, France
Co-author of the chapters Breast implant associated anaplastic large cell lymphoma and Nodal marginal zone lymphoma in the WHO Classification of Tumours of Haematopoietica and Lymphoid tissues, IARC, Lyon, France

Publications
Arianna Di Napoli is author of 83 publications, all published in International Journals with an h-index = 23 (Scopus).
1. Scarpino S, D'Alena FC, Di Napoli A, Ballarini F, Prat M, Ruco LP. Papillary carcinoma of the thyroid: evidence for a role for hepatocyte growth factor (HGF) in promoting tumour angiogenesis. J Pathol. 2003 Feb;199(2):243-50.
2. Ruco LP, Di Napoli A, Pilozzi E, Talerico C, Uccella I, Giancola ML, Alba L, Antinori A. Peripheral T cell lymphoma with cytotoxic phenotype: an emerging disease in HIV-infected patients? AIDS Res Hum Retroviruses. 2004 Feb;20(2):129-33.
3. Scarpino S, Cancellario d'Alena F, Di Napoli A, Pasquini A, Marzullo A, Ruco LP. Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid. J Pathol. 2004 Mar;202(3):352-8.
4. Scarpino S, Di Napoli A, Rapazzotti-Onelli M, Pilozzi E, Ruco L. Papillary carcinoma of the thyroid: methylation is not involved in the regulation of MET expression. Br J Cancer. 2004 Aug 16;91(4):703-6.
5. Gasbarri A, Sciacchitano S, Marasco A, Papotti M, Di Napoli A, Marzullo A, Yushkov P, Ruco L, Bartolazzi A. Detection and molecular characterisation of thyroid cancer precursor lesions in a specific subset of Hashimoto's thyroiditis. Br J Cancer. 2004 Sep 13;91(6):1096-104.
6. Pranteda G, Grimaldi M, Palese E, Di Napoli A, Bottoni U. Tufted hair folliculitis: complete enduring response after treatment with rifampicin. J Dermatolog Treat. 2004 Dec;15(6):396-8.
7. Scarpino S, Di Napoli A, Taraboletti G, Cancrini A, Ruco LP. Hepatocyte growth factor (HGF) downregulates thrombospondin 1 (TSP-1) in thyroid papillary carcinoma cells. J Pathol. 2005 Jan;205(1):50-6.
8. Grimaldi M, Pranteda G, Talerico C., Pranteda G., Di Napoli A. Acquired unilateral naevoid telangiectasia in a healthy boy. Acta Dermato-Venereologica, 2006;86:469-470.
9. Scarpino S, Di Napoli A, Stoppacciaro A, Antonelli M, Pilozzi E, Chiarle R, Palestro G, Marino M, Facciolo F, Rendina EA, Webster KE, Kinkel SA, Scott HS, Ruco L. Expression of autoimmune regulator gene (AIRE) and T regulatory cells in human thymomas. Clin Exp Immunol. 2007 Sep;149(3):504-12.
10. Scarpino S*, Di Napoli A*, Melotti F, Talerico C, Cancrini A, Ruco L. Papillary carcinoma of the thyroid: low expression of NCAM (CD56) is associated with downregulation of VEGF-D production by tumour cells. J Pathol. 2007 Aug;212(4):411-419. *These authors contributed equally to this work.
11. Di Napoli A, Signoretti S. Tissue Biomarkers in Renal Cell Carcinoma: Issues and Solutions. Cancer. 2009 May 15;115(10 Suppl):2290-7.
12. Beroukhim R, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, Linhart D, Worrell RA, Moch H, Rubin MA, Sellers WR, Meyerson M, Linehan WM, Kaelin WG Jr, Signoretti S. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res. 2009 Jun 1;69(11):4674-81.
13. Sabbisetti V, Di Napoli A, Seeley A, Amato AM, O'Regan E, Ghebremichael M, Loda M, Signoretti S. p63 promotes cell survival through fatty acid synthase. PLoS One. 2009 Jun 11;4(6):e5877.
14. Mancini R, Giarnieri E, De Vitis C, Malanga D, Roscilli G, Noto A, Marra E, Laudanna C, Zoppoli P, De Luca P, Affuso A, Ruco L, Di Napoli A, Mesiti G, Aurisicchio L, Ricci A, Mariotta S, Pisani L, Andreetti C, Viglietto G, Rendina EA, Giovagnoli MR, Ciliberto G. Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment. PLoS One. 2011;6(7):e21320.
15. Di Napoli A, Giubettini M, Duranti E, Ferrari A, Guglielmi C, Uccini S, Ruco L. Iatrogenic EBV-positive lymphoproliferative disorder with features of EBV+ mucocutaneous ulcer: evidence for concomitant TCR /IGH rearrangements in the Hodgkin-like neoplastic cells.Virchows Arch. 2011 May;458(5):631-6.
16. Pilozzi E, Cacchi C, Di Napoli A, Pini B, Duranti E, D'Andrilli A, Ruco L. Primary malignant tumour of the lung with neuroendocrine and melanoma differentiation. Virchows Arch. 2011 Aug;459(2):239-43.
17. Grisanzio C, Seeley A, Chang M, Collins M, Di Napoli A, Cheng SC, Percy A, Beroukhim R, Signoretti S. Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumours in patients. J Pathol. 2011 Oct;225(2):212-21.
18. Roscilli G, Marra E, Mori F, Di Napoli A, Mancini R, Serlupi-Crescenzi O, Virmani A, Aurisicchio L, Ciliberto G. Carnitines slow down tumor development of colon cancer in the DMH-chemical carcinogenesis mouse model. J Cell Biochem. 2013 Jul;114(7):1665-73.
19. Scarpino S, Duranti E, Giglio S, Di Napoli A, Galafate D, Del Bufalo D, Desideri M, Socciarelli F, Stoppacciaro A and Ruco L. Papillary carcinoma of the thyroid: high exprtession of Cox-2 and low expression of KAI/CD82 are associated with increased tumor invasiveness. Thyroid. 2013. Sep;23(9):1127-37.
20. Pelliccia S, Di Napoli A, Naso V, Alma E, Rebecchini C, Cox MC. Very long lasting remission of refractory T-Large Granular Lymphocytes Leukemia and myeloma by lenalidomide treatment. European Journal of Haematology. 2013 Aug;91(2):183-6.
21. Di Napoli A, Al-Jadiri MF, Talerico C, Duranti E, Pilozzi E, Trivedi P, Anastasiadu E, Alsaadawi AR, Al-Darraji AF., Al-Hadad SA., Testi AM, Uccini S, Ruco L. Immunophenotipic and molecular aspects of EBV+ classic Hodgkin lymphoma of Iraqi children. Pediatric Blood & Cancer. 2013 Dec;60(12):2068-72.
22. Noto A, Raffa S, De Vitis C, Roscilli G, Malpicci D, Coluccia P, Di Napoli A, Ricci A, Giovagnoli MR, Aurisicchio L, Torrisi MR, Ciliberto G, Mancini R. Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells. Cell Death Dis. 2013 Dec 5;4:e947.
23. Pranteda G, Carlesimo M, Bottoni U, Di Napoli A, Muscianese M, Pimpinelli F, Cordiali P, Laganà B, Pranteda G, Di Carlo A. Pemphigus vulgaris in a patient with arthritis and uveitis: successful treatment with immunosuppressive therapy and acyclovir. Dermatol Ther. 2014 Feb 18.
24. Roscilli G, Cappelletti M, De Vitis C, Ciliberto G, Di Napoli A, Ruco L, Mancini R, Aurisicchio L. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. J Transl Med. 2014 Feb 24;12:54. doi: 10.1186/1479-5876-12-54.
25. Cox MC*, Di Napoli A*, Scarpino S, Salerno G, Tatarelli C, Talerico C, Lombardi M, Monarca B, Amadori S, Ruco L. Clinicopathologic Characterization of Diffuse-Large-B-Cell Lymphoma with an Associated Serum Monoclonal IgM Component. PLoS One. 2014 Apr 4;9(4):e93903. *These authors contributed equally to this work.
26. Cox MC, Di Napoli A, Scarpino S, Ruco L. The immunoglobulin isotype matters in diffuse-large-B-cell lymphoma with serum paraproteinaemia. Ann Hematol. 2014 Sep 6.
27. Scarpino S, Pulcini F, Di Napoli A, Giubettini M, Ruco L. EGFR mutation testing in pulmonary adenocarcinoma: Evaluation of tumor cell number and tumor percent in paraffin sections of 120 small biopsies. Lung Cancer. 2015 Jan;87(1):8-13. doi: 10.1016/j.lungcan.2014.10.012. Epub 2014 Nov 3.
28. Cox MC, Battella S, La Scaleia R, Pelliccia S, Di Napoli A, Porzia A, Cecere F, Alma E, Zingoni A, Mainiero F, Ruco L, Monarca B, Santoni A, Palmieri G. Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients. OncoImmunology. 01/2015.
29. Cherubini E, Di Napoli A, Noto A, Osman GA, Esposito MC, Mariotta S, Sellitri R, Ruco L, Cardillo G, Ciliberto G, Mancini R, Ricci A. Genetic and Functional Analysis of Polymorphisms in the Human Dopamine Receptor and Transporter Genes in Small Cell Lung Cancer. J Cell Physiol. 2015 Jun 16.
30. Fattore L, Malpicci D, Marra E, Belleudi F, Noto A, De Vitis C, Pisanu ME, Coluccia P, Camerlingo R, Roscilli G, Ribas A, Di Napoli A, Torrisi MR, Aurisicchio L, Ascierto PA, Mancini R, Ciliberto G. Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma. Oncotarget. 2015 Sep 22;6(28):24823-41.
31. Di Napoli A, Mallel G, Bartolazzi A, Cavalieri E, Becelli R, Cippitelli C, Ruco L. Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. Int J Surg Pathol. 2015 Aug;23(5):419-23.
32. Santanelli di Pompeo F, Laporta R, Sorotos M, Di Napoli A, Giovagnoli MR, Cox MC, Campanale A, Longo B. Breast Implant-Associated Anaplastic Large Cell Lymphoma: Proposal for a Monitoring Protocol. Plast Reconstr Surg. 2015 Aug;136(2):144e-51e.
33. Cencini E, Fabbri A, Rigacci L, Lazzi S, Gini G, Cox MC, Mancuso S, Abruzzese E, Kovalchuk S, Goteri G, Di Napoli A, Bono R, Fratoni S, Di Lollo S, Bosi A, Leoncini L, Bocchia M. Evaluation of the prognostic role of tumour-associated macrophages in newly diagnosed classical Hodgkin lymphoma and correlation with early FDG-PET assessment. Hematol Oncol. 2017 Mar;35(1):69-78.
34. Clemens MW, Medeiros LJ, Butler CE, Hunt KK, Fanale MA, Horwitz S, Weisenburger DD, Liu J, Morgan EA, Kanagal-Shamanna R, Parkash V, Ning J, Sohani AR, Ferry JA, Mehta-Shah N, Dogan A, Liu H, Thormann N, Di Napoli A, Lade S, Piccolini J, Reyes R, Williams T, McCarthy CM, Hanson SE, Nastoupil LJ, Gaur R, Oki Y, Young KH, Miranda RN. Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma. J Clin Oncol. 2016 Jan 10;34(2):160-8.
35. Scarpino S, Rampioni Vinciguerra GL, Di Napoli A, Fochetti F, Uccini S, Iacono D, Marchetti P, Ruco L. High prevalence of ALK+/ROS1+ cases in pulmonary adenocarcinoma of adoloscents and young adults. Lung Cancer. 2016 Jul;97:95-8.
36. Di Napoli A, Jain P, Duranti E, Margolskee E, Arancio W, Facchetti F, Alobeid B, Santanelli di Pompeo F, Mansukhani M, Bhagat G. Targeted next generation sequencing of Breast Implant Associated Anaplastic Large Cell Lymphoma reveals mutations in JAK/STAT signaling pathway genes, TP53 and DNMT3A. Br J Haematol. 2016 Nov 10. doi: 10.1111/bjh.14431.
37. Noto A, De Vitis C, Pisanu ME, Roscilli G, Ricci G, Catizone A, Sorrentino G, Chianese G, Taglialatela-Scafati O, Trisciuoglio D, Del Bufalo D, Di Martile M, Di Napoli A, Ruco L, Costantini S, Jakopin Z, Budillon A, Melino G, Del Sal G, Gennaro Ciliberto G, Mancini R. Stearoyl-CoA-Desaturase (SCD1) regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ . Oncogene 2017. In Press.
38. Gorini F, Azzimonti L, Delfanti G, Scarfò L, Scielzo C, Bertilaccio MT, Ranghetti P, Gulino A, Doglioni C, Di Napoli A, Capri M, Franceschi C, Caligaris-Cappio F, Ghia P, Bellone M, Dellabona P, Casorati G, de Lalla C. Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis. Blood. 2017 May 2. pii: blood-2016-11-751065. doi: 10.1182/blood-2016-11-751065.
39. Battella S, Cox MC, La Scaleia R, Di Napoli A, Di Landro F, Porzia A, Franchitti L, Mainiero F, Ruco L, Monarca B, Santoni A, Palmieri G.Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy. Cancer Immunol Immunother. 2017 May 29. doi: 10.1007/s00262-017-2026-7.
40. Di Napoli A, Pepe G, Giarnieri E, Cippitelli C, Bonifacino A, Mattei M, Martelli M, Falasca C, Cox MC, Santino I, Giovagnoli MR. Cytological diagnostic features of late breast implant seromas: From reactive to anaplastic large cell lymphoma. PLoS One. 2017 Jul 17;12(7):e0181097.
41. Cox MC, Di Napoli A, Fabbri A, Cencini E, Ruco L. The significance of serum immunoglobulin paraprotein in diffuse large B-cell lymphoma. Br J Haematol. 2017 Aug 17. doi: 10.1111/bjh.14873. [Epub ahead of print].
42. Ferretti E, Hohaus S, Di Napoli A, Belmonte B, Cuccaro A, Cupelli E, Galli E, Rufini V, Tripodi G, Fraternali-Orcioni G, Pistoia V, Corcione A. Interleukin-31 and thymic stromal lymphopoietin expression in plasma and lymph node from Hodgkin lymphoma patients. Oncotarget Volume 8, Issue 49, 17 October 2017, 85263-85275.
43. Ferrufino-Schmidt MC, Medeiros LJ, Liu H, Clemens MW, Hunt KK, Laurent C, Lofts J, Amin MB, Ming Chai S, Morine A, Di Napoli A, Dogan A, Parkash V, Bhagat G, Tritz D, Quesada AE, Pina-Oviedo S, Hu Q, Garcia-Gomez FJ, Jose Borrero J, Horna P, Thakral B, Narbaitz M, Hughes RC 3rd, Yang LJ, Fromm JR, Wu D, Zhang D, Sohani AR, Hunt J, Vadlamani IU, Morgan EA, Ferry JA, Sziget R, C Tardio J, Granados R, Dertinger S, Offner FA, Pircher A, Hosry J, Young KH, Miranda RN. Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma. Am J Surg Pathol. 2018 Mar;42(3):293-305.
44. Vacca D, Cancila V, Gulino A, Lo Bosco G, Belmonte B, Di Napoli A, Florena AM, Tripodo C, Arancio W. Real-time detection of BRAF V600E mutation from archival hairy cell leukemia FFPE tissue by nanopore sequencing. Mol Biol Rep. 2018 Feb;45(1):1-7.
45. Nava MB, Adams WP Jr, Botti G, Campanale A, Catanuto G, Clemens MW, Del Vecchio DA, De Vita R, Di Napoli A, Hall-Findlay E, Hammond D, Heden P, Mallucci P, Martin Del Yerro JL, Muti E, Rancati A, Randquist C, Salgarello M, Stan C, Rocco N. MBN 2016 Aesthetic Breast Meeting BIA-ALCL Consensus Conference Report. Plast Reconstr Surg. 2018 Jan;141(1):40-48.
46. Cocco E, Leo M, Canzonetta C, Di Vito S, Mai A, Rotili D, Di Napoli A, Vecchione A, De Nunzio C, Filetici P, Stoppacciaro A. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44.
47. Pepe G*, Di Napoli A*, Cippitelli C, Scarpino S, Pilozzi E, Ruco L. Reduced lymphotoxin-beta production by tumour cells is associated with loss of follicular dendritic cell phenotype and diffuse growth in follicular lymphoma. J Pathol Clin Res. 2018 Apr;4(2):124-134. *These authors contributed equally to this work.
48. Del Porto F, Tatarelli C, Di Napoli A, Proietta M. Systemic lupus erythematosus and myelofibrosis: A case report and revision of literature. Leuk Res Rep. 2018 Apr 10;9:58-64.
49. Nava M. B., Di Napoli A, Clemens M, Catanuto G, Rocco N. Genetic markers and molecular tests for BIA-ALCL screening: are we really ready for this? Plast Reconstr Surg. 2018. Dec; 142 (6): 969e 971e.
50. Di Napoli A, De Cecco L, Piccaluga PP, et al. Transcriptional analysis distinguishes breast implant-associated anaplastic large cell lymphoma from other peripheral T-cell lymphomas. Mod Pathol. 2019 Feb;32(2):216-230. doi: 10.1038/s41379-018-0130-7. Epub 2018 Sep 11.
51. Rau JV, Marini F, Fosca M, Cippitelli C, Rochhia M, Di Napoli A. Raman spectroscopy discriminates malignant follicular lymphoma from benign follicular hyperplasia and from tumour metastasis. Talanta 194 (2019) 763 770.
52. Di Napoli A. Achieving Reliable Diagnosis in Late Breast Implant Seromas: From reactive to anaplastic large cell lymphoma. Plast Reconstr Surg. 2019 Mar;143 (3S A Review of Breast Implant-Associated Anaplastic Large Cell Lymphoma):15S-22S.
53. Cox MC1, Pelliccia S, Marcheselli L, Battistini R,mArcari A, Borza Anticoli P, Patti C, Casaroli I, di Landro F, Di Napoli A, Fabbri F, Caridi M, Tafuri A, Bocci G, Musuraca G. The metronomic all-oral DEVEC is an effective schedule in elderlypatients with diffuse large b-cell lymphoma. Invest New Drugs. 2019 Jun;37(3):548-558.
54. Tabanelli V, Corsini C, Fiori S, Agostinelli C, Calleri A, Orecchioni S, Melle F, Motta G, Rotili A, Di Napoli A*, Pileri SA*. Recurrent PDL1 expression and PDL1 (CD274) copy number alterations in breast implant-associated anaplastic large-cell lymphomas. Hum Pathol.2019 Aug;90:60-69. *These authors contributed equally to this work.
55. Cox MC, Castiello L, Mattei M, Santodonato L, D'Agostino G, Muraro E, Martorelli D, Lapenta C, Di Napoli A, Di Landro F, Cangemi M, Pavan A, Castaldo P, Hohaus S, Donati S, Montefiore E, Berdini C, Carlei D, Monque DM, Ruco L, Prosperi D, Tafuri A, Spadaro F, Sestili P, Spada M, Dolcetti R, Santini SM, Rozera C, Aricò E, Capone I, Belardelli F. Clinical and antitumor immune responses In Relapsed/Refractory Follicular Lymphoma patients after intranodal injections of IFN -Dendritic Cells and Rituximab. Clin Cancer Res. 2019 Jun 6. pii: clincanres.0709.2019. doi: 10.1158/1078-0432.CCR-19-0709.
56. Uccini S, Al-Jadiry MF, Pepe G, Pasquini A, Alsaadawi AR, Al-Hadad SA, Di Napoli A, Tripodo C, Ruco L. Follicular dendritic cells display microvesicle-associated LMP1 in reactive germinal centers of EBV+ classic Hodgkin lymphoma. Virchows Arch. 2019 Jun 15. doi: 10.1007/s00428-019-02605-w.
57. Annibali O, Hohaus S, Marchesi F, Cantonetti M, Di Rocco A, Tomarchio V, Di Napoli A, Pelliccia S, Battistini R, Anticoli Borza P, Abruzzese E, Cenfra N, Andriani A, Tesei C, Alma E, Palombi F, Pupo L, Petrucci L, Becilli M, Maiolo E, Bellesi S, Cuccaro A, D'Alò F, Cox MC. The neutrophil/lymphocyte ratio 3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network 'Rete Ematologica del Lazio per i Linfomi' (RELLI). Leuk Lymphoma. 2019 Jul 1:1-9. doi: 10.1080/10428194.2019.1633628.
58. Filetti M, Giusti R, Di Napoli A, Iacono D, Marchetti P. Unexpected serious aplastic anemia from PD-1 inhibitors: beyond what we know. Tumori. 2019 Jun 21:300891619856197. doi: 10.1177/0300891619856197.
59. Di Napoli A, Remotti D, Agostinelli C, Ambrosio MR, Ascani S, Carbone A, Facchetti F, Lazzi S, Leoncini L, Lucioni M, Novero D, Pileri S, Ponzoni M, Sabattini E, Tripodo C, Zamò A, Paulli M, Ruco L A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit : A position paper from the Italian Group of Haematopathology (G.I.E.). Virchows Arch. 2019 Aug 6. doi: 10.1007/s00428-019-02637-2.
60. Lyapichev KA, Piña-Oviedo S, Medeiros LJ, Evans MG, Liu H, Miranda AR, Hunt KK, Clemens MW, Stewart JM, Amin MB, Quesada AE, Chai SM, Di Napoli A, Yoga A, Dave SK, Wistuba II, Wu Y, Bueso-Ramos CE, Schlette EJ, Ferrufino-Schmidt MC, Loghavi S, Khoury JD, Young KH, Miranda RN. A proposal for pathologic processing of breast implant capsules in patients with suspected breast implant anaplastic large cell lymphoma. Mod Pathol. 2019 Aug 5. doi: 10.1038/s41379-019-0337-2.
61. Tisi MC, Ferrero S, Dogliotti I, Tecchio C, Carli G, Novo M, Stefani PM, Rattotti S, Balzarotti M, Marino D, Pelosini M, Romano A, Flenghi L, Zilioli VR, Calimeri T, Di Napoli A, Zanni M, Finolezzi E, Mosna F, Gini G, Mansueto G, Di Rocco A, Tomei G, Sgherza N, Olivieri J, Nassi L, Piazza F, Fama A, Greco A, Giannoccaro M, Mazzone AM, Visco C, Loseto G, Zaja F. MYC Rearranged Aggressive B-Cell Lymphomas: A Report on 100 Patients of the Fondazione Italiana Linfomi (FIL). Hemasphere. 2019 Oct 22;3(6):e305.
62. Kadin ME, Adams WP Jr, Inghirami G, Di Napoli A. Does Breast Implant Associated ALCL begin as a Lymphoproliferative Disorder? Plast Reconstr Surg. 2020 Jan;145(1):30e-38e. doi: 10.1097/PRS.0000000000006390.
63. Mazzotta M, Filetti M, Rossi A, Roberto M, Occhipinti M, Pernazza A, Di Napoli A, Scarpino S, Vecchione A, Giusti R, Marchetti P. Is there a place for crizotinib in c-MET alterations? A case of efficacy in ALK positive NSCLC patient with secondary c-MET amplification. Ann Oncol. 2020 Mar;31(3):440-441. doi: 10.1016/j.annonc.2019.11.016. Epub 2019 Dec 9.
64. Flores KR, Viccaro F, Aquilini M, Scarpino S, Ronchetti F, Mancini R, Di Napoli A, Scozzi D, Ricci A. Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients. PLoS One. 2020 Jan 17;15(1):e0227834. doi: 10.1371/journal.pone.0227834. eCollection 2020.
65. Minaf YA, Del Padre M, Cristofoletti C, Caprini E, Perez M, Aranburu A, Colantuono S, Gragnani L, Zignego AL, Pulsoni A, Di Napoli A, Casato M, Fiorilli M, Visentini M. A stereotyped light chain may shape virus-specific B-cell receptors in HCV-dependent lymphoproliferative disorders. Genes Immun. 2020 Feb 18. doi: 10.1038/s41435-020-0093-9. [Epub ahead of print].
66. Granai M, Amato T, Di Napoli A, Santi R3, Vergoni F, Di Stefano G, Mancini V, Kovalchuk S, Cencini E, Carta AG, Aversa S, Ziepert M, Cevenini G, Lazzi S, Leoncini L, Bellan C. IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications. Virchows Arch. 2019 Dec 4. doi: 10.1007/s00428-019-02712-8.
67. Mazzotta M, Filetti M, Occhipinti M, Marinelli D, Scalera S, Terrenato I, Sperati F, Pallocca M, Rizzo F, Gelibter A, Botticelli A, Scafetta G, Di Napoli A, Krasniqi E, Pizzuti L, Barba M, Carpano S, Vici P, Fanciulli M, De Nicola F, Ciuffreda L, Goeman F, De Maria R, Vecchione A, Giusti R, Ciliberto G, Marchetti P, Maugeri-SaccaÃÄ M. Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes. J Immunother Cancer. 2020 Aug;8(2):e000946. doi: 10.1136/jitc-2020-000946.
68. Mangogna A, Cox MC, Ruco L, Lopez G, Belmonte B, Di Napoli A. Rituximab plus chemotherapy provides no clinical benefit in a peripheral T-cell lymphoma not otherwise specified with aberrant expression of CD20 and CD79a: A case report and review of the literature. Diagnostics (Basel). 2020 May 26;10(6):341.
69. Di Napoli A, Greco D, Scafetta G, Ascenzi F, Gulino A, Aurisicchio L, Santanelli Di Pompeo F, Bonifacino A, Giarnieri E, Morgan J, Mancini R, Kadin ME. IL-10, IL-13, Eotaxin and IL-10/IL-6 ratio distinguish breast implant associated anaplastic large cell lymphoma from all types of benign late seromas. Cancer Immunol Immunother. 2020. In Press.
70. Sangaletti S, Iannelli F, Zanardi F, Cancila V, Portararo P, Botti L, Vacca D, Chiodoni C, Di Napoli A, Valenti C, Rizzello C, Vegliante MC, Pisati F, Gulino A, Ponzoni M, Colombo MP, Tripodo C. Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces. E Biomedicine. 2020; 61.
71. Cox MC, Banchi M, Pelliccia S, Di Napoli A, Marcheselli L, Patti C, Anticoli Borza P, Battistini R, Di Gregorio F, Orlandi P, Bocci G. All-oral metronomic DEVEC schedule in elderly patients with peripheral T cell lymphoma. Cancer Chemotherapy and Pharmacology, 2020, 86(6), pp. 841-846.
72. Tripodo, C., Zanardi, F., Iannelli, F., Mazzara, S., Vegliante, M., Morello, G., Di Napoli, A., Mangogna, A., Facchetti, F., Sangaletti, S., Chiodoni, C., VanShoiack, A., Jeyasekharan, A.D., Casola, S., Colombo, M.P., Ponzoni, M., Pileri, S.A. A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas. iScience. 2020 Sep 16;23(10):101562. doi: 10.1016/j.isci.2020.101562. eCollection 2020 Oct 23.
73. DeCoster RC, Clemens MW, Di Napoli A, Lynch EB, Bonaroti AR, Rinker BD, Butterfield TA, Vasconez HC. Cellular and Molecular Mechanisms of Breast Implant-Associated Anaplastic Large Cell Lymphoma. Plast Reconstr Surg. 2021 Jan 1;147(1):30e-41e. doi: 10.1097/PRS.0000000000007423. PMID: 33370049.
74. Vaisitti T, Arruga F, Vitale N, Lee TT, Ko M, Chadburn A, Braggio E, Di Napoli A, Iannello A, Allan J, Miller LL, Lannutti BJ, Furman RR, Jessen K, Deaglio S. ROR1 targeting with the antibody drug-conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. Blood. 2021 Jan 14:blood.2020008404. doi: 10.1182/blood.2020008404. Epub ahead of print. PMID: 33512452.
75. Bettelli S, Marcheselli R, Pozzi S, Marcheselli L, Papotti R, Forti E, Cox MCC, Di Napoli A, Tadmor T, Mansueto GR, Musto P, Flenghi L, Quintini M, Galimberti S, Lalinga V, Donati V, Maiorana A, Polliack A, Sacchi S. Cell of origin (COO), BCL2/MYC status and IPI define a group of patients with Diffuse Large B-cell Lymphoma (DLBCL) with poor prognosis in a real-world clinical setting. Leuk Res. 2021 Feb 27;104:106552.

76. Iannello A, Vitale N, Coma S, Arruga F, Chadburn A, Di Napoli A, Laudanna C, Allan JN, Furman RR, Pachter JA, Deaglio S, Vaisitti T. Synergistic efficacy of the dual PI3K- / inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models. Blood. 2021 Jun 17;137(24):3378-3389. doi: 10.1182/blood.2020010187. PMID: 33786583.

77. Campanale A, Di Napoli A, Ventimiglia M, Pileri S, Minella D, Curigliano G, Martelli M, De Vita R, Di Giulio P, Montorsi M, Veronesi P, Giordano S, Iachino A, Lispi L. Chest wall infiltration is a critical prognostic factor in breast implant-associated anaplastic large-cell lymphoma affected patients. Eur J Cancer. 2021 Mar 22;148:277-286. Doi: 10.1016/j.ejca.2021.01.041. Online ahead of print

78. Sciacchitano S, De Vitis C, D'Ascanio M, Giovagnoli S, De Dominicis C, Laghi A, Anibaldi P, Petrucca A, Salerno G, Santino I, Amodeo R, Simmaco M, Napoli C, Tafuri A, Di Napoli A, Sacconi A, Salvati V, Ciliberto G, Fanciulli M, Piaggio G, de Latouliere L, Ricci A, Mancini R. Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies. J Transl Med. 2021 Apr 1;19(1):139. doi: 10.1186/s12967-021-02805-6.

79. Bardelli F, Brun F, De Panfilis S, Cloetens P, Capella S, Belluso E, Bellis D, Di Napoli A, Cedola A. Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free x-ray imaging and spectroscopic techniques. Toxicol Lett. 2021 May 20;348:18-27. doi: 10.1016/j.toxlet.2021.05.002. Epub ahead of print. PMID: 34023437.

80. Mariani S, Pelliccia S, Bianchi MP, Piedimonte M, Bongiovanni M, Testa M, Di Napoli A, Tafuri A. Arrhythmias and Cardiogenic Shock: A Rare Disease Presentation of Diffuse Large B-Cell Lymphoma with Cardiac Involvement. Hemato 2021, 2(2), 353-357; https://doi.org/10.3390/hemato2020021

81. Rossella Elia, Michele Maruccia, Aurelia De Pascale, Arianna Di Napoli, Giuseppe Ingravallo, Giuseppe Giudice. The management of breast implant-associated anaplastic large cell lymphoma in the setting of pregnancy: seeking for clinical practice guidelines. Arch Plast Surg. 2021;48(4):373-377. Published online July 15, 2021 DOI: https://doi.org/10.5999/aps.2021.00185.

82. Sacconi A, De Vitis C, de Latouliere L, di Martino S, De Nicola F, Goeman F, Mottini C, Paolini F, D'Ascanio M, Ricci A, Tafuri A, Marchetti P, Di Napoli A, De Biase L, Negro A, Napoli C, Anibaldi P, Salvati V, Duffy D, Terrier B, Fanciulli M, Capalbo C, Sciacchitano S, Blandino G, Piaggio G, Mancini R, Ciliberto G. Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients. Cell Death Dis. 2021 Oct 29;12(11):1019. doi: 10.1038/s41419-021-04299-y. PMID: 34716309.

83. Di Napoli A, Firmani G, Sorotos M, Lopez G, Noccioli N, De Sanctis V, Tafuri A, Santanelli di Pompeo F. Successful Treatment of a Patient With Breast Implant-Associated Anaplastic Large Cell Lymphoma With Local Residual Disease: A Case Report. Ann Plast Surg. 2021 Oct 26. doi: 10.1097/SAP.0000000000003033. Epub ahead of print. PMID: 34711728.

Date
30/10/2021