Catalogo dei Corsi di studio

DATI PERSONALI
Nome e Cognome BRUNO MARAS
Dipartimento Scienze Biochimiche
Indirizzo
P.le Aldo Moro 5, 00185 Roma
Telefono uff./lab./mobile 0649910986 / 0649910861
Fax 064440062
E-mail bruno.maras@uniroma1.it

Settore Scientifico-Disciplinare: BIO10
Orario di Ricevimento: mercoledì 15-17 - venerdì 10-12

ATTUALE POSIZIONE
Professore associato di Biochimica al Corso di Laurea magistrale E Facoltà di Farmacia e Medicina Sapienza Università di Roma

CARRIERA E TITOLI

1985 Laurea in Scienze Biologiche
1990 Dottorato di Ricerca in Biochimica
1990 Tecnico laureato
2000 Ricercatore confermato (SSD BIO11- Biologia molecolare)
2001 Professore associato (SSD BIO10 - Biochimica generale)

ATTIVITA DIDATTICA
1) Corso Integrato di Biochimica nella Laurea Magistrale in Medicina e Chirurgia Polo Pontino, Corso E. Coordinatore del Corso Integrato.
2) Collegio dei Docenti Dottorato in Biochimica

ATTIVITA SCIENTIFICA
Enzimi a piridossal fosfato e folato Basi biochimiche della resistenza ai farmaci in Candida albicans - Proteomica della neurodegenerazione : malattie prioniche e Alzheimer
Collaborazioni: Prof. Maurizio Pocchiari Istituto Superiore di Sanità
Prof. Antonio Cassone Università di Perugia
Prof. Michele Mazzanti Politecnico di Milano
Istituto Zooprofilattico di Torino

PUBBLICAZIONI SCIENTIFICHE (max 30 su un totale di 90)
A. Peer reviewed publications of BrunoMaras: selezionate (ultimi 15 anni)

1. POMPILI E, FABRIZI C, SOMMA F, CORREANI V, MARAS B, SCHININÀ ME, CIRACI V, ARTICO M, FORNAI F, FUMAGALLI L (2017). PAR1 activation affects the neurotrophic properties of Schwann cells. Mol Cell Neurosci. 2017 Mar;79:23-33. doi: 10.1016/j.mcn.2017.01.001 I.F. 3.6
2. MARTIRE S, FUSO A, MOSCA L, FORTE E, CORREANI V, FONTANA M, SCARPA S, MARAS B, D'ERME M (2016). Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions. J Alzheimers Dis. 2016 Aug 10;54(1):307-24. doi: 10.3233/ I.F. 3.9
3. BAIOCCHINI A, MONTALDO C, CONIGLIARO A, GRIMALDI A, CORREANI V, MURA F, CICCOSANTI F, ROTIROTI N, BRENNA A, MONTALBANO M, D'OFFIZI G, CAPOBIANCHI MR, ALESSANDRO R, PIACENTINI M, SCHININÀ ME, MARAS B, DEL NONNO F, TRIPODI M, MANCONE C (2016). Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution. PLoS One. 2016 Mar 21;11(3):e0151736. doi10.1371/journal.pone.0151736 I.F. 3.5
4. PAIARDINI A, TRAMONTI A, SCHIRCH D, GUIDUCCI G, DI SALVO ML, FIASCARELLI A, GIORGI A, MARAS B, CUTRUZZOLÀ F (2016), CONTESTABILE R. Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming. Biochim Biophys Acta. 2016 Nov;1864(11):1506-17. doi: 10.1016/j.bbapap.2016.08.010 I.F. 5.5
5. CORREANI V, DI FRANCESCO L, CERA I, MIGNOGNA G, GIORGI A, MAZZANTI M, FUMAGALLI L, FABRIZI C, MARAS B, SCHININÀ ME(2015). Reversible redox modifications in the microglial proteome challenged by beta amyloid. Mol Biosyst. 2015 Jun;11(6):1584-93. doi: 10.1039/c4mb00703d I.F. 2.8
6. EUFEMI M, COCCHIOLA R, ROMANIELLO D, CORREANI V, DI FRANCESCO L, FABRIZI C, MARAS B, SCHININÀ ME(2015). Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid. Neurochem Int. 2015 Feb;81:48-56. doi: 10.1016/j.neuint.2015.01.007 I.F. 3.4
7. MARAS B, ANGIOLELLA L, MIGNOGNA G, VAVALA E, MACONE A, COLONE M, PITARI G, STRINGARO A, DUPRÉ S, PALAMARA AT (2014). Glutathione metabolism in Candida albicans resistant strains to fluconazole and micafungin. PLoS One. 2014 Jun 4;9(6):e98387. doi: 10.1371/journal.pone.0098387I.F 4.6
8. CARDONE F, PRINCIPE S, SCHININÀ ME, MARAS B, CAPELLARI S, PARCHI P, NOTARI S, DI FRANCESCO L, POLEGGI A, GALENO R, VINCI R, MELLINA V, ALMONTI S, LADOGANA A, POCCHIARI M (2014). Mutant PrPCJD prevails over wild-type PrPCJD in the brain of V210I and R208H genetic Creutzfeldt-Jakob disease patients. Biochem Biophys Res Commun. 2014 Nov 14;454(2):289-94. doi: 10.1016/j.bbrc.2014.10.051 I.F. 2.4
9. MARTIRE S, FUSO A, ROTILI D, TEMPERA I, GIORDANO C, DE ZOTTIS I, MUZI A,VERNOLE P, GRAZIANI G, LOCOCO E, FARALDI M, MARAS B, SCARPA S, MOSCA L, D'ERME M (2013). PARP-1 modulates amyloid beta peptide-induced neuronal damage. PLoS One. 2013 Sep 24;8(9):e72169. doi: 10.1371/journal.pone.0072169 I.F. 3.5
10. DI SALVO ML, CONTESTABILE R, PAIARDINI A, MARAS B (2013). Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection. Med Hypotheses. 2013 May;80(5):633-6. doi:10.1016/j.mehy.2013.02.008 I.F. 1.1
11. DI FRANCESCO L, CORREANI V, FABRIZI C, FUMAGALLI L, MAZZANTI M, MARAS B, SCHININÀ ME (2012). 14-3-3 MARKS THE AMYLOID-STIMULATED MICROGLIA LONG-TERM ACTIVATION. Proteomics. 2012 Jan;12(1):124-34. doi: 10.1002/pmic.201100113 I.F. 4.0
12. SORRENTINO S, BUCCIARELLI T, CORSARO A, TOSATTO A, THELLUNG S, VILLA V, SCHININÀ ME, MARAS B, GALENO R, SCOTTI L, CREATI F, MARRONE A, RE N, ACETO A, FLORIO T, MAZZANTI M (2012). Calcium binding promotes prion protein fragment 90-231conformational change toward a membrane destabilizing and cytotoxic structure. PLoS One. 2012;7(7):e38314. doi: 10.1371/journal.pone.0038314 I.F. 3.5
13. PAULIS D, MARAS B, SCHININÀ ME, DI FRANCESCO L, PRINCIPE S, GALENO R,ABDEL-HAQ H, CARDONE F, FLORIO T, POCCHIARI M, MAZZANTI M (2011). The pathological prion protein forms ionic conductance in lipid bilayer. Neurochem Int. 2011Aug;59(2):168-74. doi: 10.1016/j.neuint.2011.04.008 I.F. 3.4
14. GIORGI A, DI FRANCESCO L, PRINCIPE S, MIGNOGNA G, SENNELS L, C. MANCONE, ALONZI T, SBRICCOLI M, DE PASCALIS A, RAPPSILBER J, CARDONE F, POCCHIARI M, MARAS B., SCHININA ME (2009). Proteomic profiling of PrP27-30-enriched preparations extracted from the brain of hamsters with experimental scrapie. PROTEOMICS, vol. 9(15); p. 3802-3814, ISSN: 1615-9853, doi: 10.1002/pmic.200900085 I.F. 4.6
15. MILEO AM, ABBRUZZESE C, MATTAROCCI S, BELLACCHIO E, PISANO P, FEDERICO A, MARESCA V, PICARDO M, GIORGI A, MARAS B., M. SCHININA', PAGGI MG (2009). Human papillomavirus-16 E7 interacts with glutathione S-transferase P1 and enhances its role in cell survival. PLOS ONE, vol. 4(10); p. e7254-e7254, ISSN: 1932-6203, doi: 10.1371/journal.pone.0007254 I.F. 4.6
16. TOROSANTUCCI A, CHIANI P, BROMURO C, DE BERNARDIS F, PALMA AS, LIU Y, G. MIGNOGNA, MARAS B., COLONE M, STRINGARO A, ZAMBONI S, FEIZI T, CASSONE A (2009). Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence. PLOS ONE, vol. 4(4); p. 1-17, ISSN: 1932-6203, doi: 10.1371/journal.pone.0005392 I.F. 4.6
17. DI LEANDRO L, MARAS B., SCHININÄ ME, DUPR â S, KOUTRIS I, MARTIN FM, NAQUET P, GALLAND F, PITARI G (2008). Cystamine restores GSTA3 levels in Vanin-1 null mice. FREE RADICAL BIOLOGY & MEDICINE, vol. 44(6); p. 1088-1096, ISSN: 0891-5849, doi: 10.1016/j.freeradbiomed.2007.12.015 I.F. 5.7
18. PRINCIPE S, MARAS B., SCHININÄ ME, POCCHIARI M, CARDONE F (2008). Unraveling the details of prion (con)formation(s): recent advances by mass spectrometry. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, vol. 11(5); p. 697-707, ISSN: 1367-6733 I.F. 4.5
19. ZANUSSO G, POLO A, FARINAZZO A, NONNO R, CARDONE F, DI BARI M, FERRARI S, PRINCIPE S, GELATI M, FASOLI E, FIORINI M, PRELLI F, FRANGIONE B, TRIDENTE G, BENTIVOGLIO M, GIORGI A, SCHININA ME, MARAS B., AGRIMI U, RIZZUTO N, POCCHIARI M, MONACO S (2007). Novel prion protein conformation and glycotype in Creutzfeldt-Jakob disease. ARCHIVES OF NEUROLOGY, vol. 64(4); p. 595-599, ISSN: 0003-9942 I.F. 7.1
20. CARTONI C, SCHININA ME, MARAS B., NONNO R, VACCARI G, DI BARI M, CONTE M, DE PASCALIS A, PRINCIPE S, CARDONE F, POCCHIARI M, AGRIMI U (2006). Quantitative profiling of the pathological prion protein allotypes in bank voles by liquid chromatography-mass spectrometry. JOURNAL OF CHROMATOGRAPHY. B, vol. 849(1-2); p. 302-306, ISSN: 1570-0232, doi: 10.1016/j.jchromb.2006.08.016 I.F. 3.0
21. ANGIOLELLA L, MARAS B., STRINGARO AR, ARANCIA G, MONDELLO F, GIROLAMO A, PALAMARA AT, CASSONE A (2005). Glucan-associated protein modulations and ultrastructural changes of the cell wall in Candida albicans treated with micafungin, a water-soluble, lipopeptide antimycotic. JOURNAL OF CHEMOTHERAPY, vol. 17(4); p. 409-416, ISSN: 1120-009X I.F. 1.14
22. BERTOLDI M, CELLINI B, MARAS B., VOLTATTORNI CB (2005). A quinonoid is an intermediate of oxidative deamination reaction catalyzed by Dopa decarboxylase. FEBS LETTERS, vol. 579(23); p. 5175-5180, ISSN: 0014-5793, doi: 10.1016/j.febslet.2005.08.029 I.F. 3.6
23. CAPELLARI S, CARDONE F, NOTARI S, SCHININA ME, MARAS B., SITA D, BARUZZI A, POCCHIARI M, PARCHI P (2005). Creutzfeldt-Jakob disease associated with the R208H mutation in the prion protein gene. NEUROLOGY, vol. 64(5); p. 905-907, ISSN: 0028-3878 I.F. 8.0
24. CARTONI C, SCHININA ME, MARAS B., NONNO R, VACCARI G, DI BARIA MA, CONTE M, LIU QG, LU M, CARDONE F, WINDL O, POCCHIARI M, AGRIMI U (2005). Identification of the pathological prion protein allotypes in scrapie-infected heterozygous bank voles (Clethrionomys glareolus) by high-performance liquid chromatography-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, vol. 1081(1); p. 122-126, ISSN: 0021-9673, doi: 10.1016/j.chroma.2005.04.035 I.F.4.2
25. MIGNOGNA G, GIORGI A, STEFANELLI P, NERI A, COLOTTI G, MARAS B., SCHININA ME (2005). Inventory of the proteins in Neisseria meningitidis serogroup B strain MC58. JOURNAL OF PROTEOME RESEARCH, vol. 4(4); p. 1361-1370, ISSN: 1535-3893, doi: 10.1021/pr0500511 I.F. 5.6
26. SCHININA ME, PITARI G, PAOLONE T, GIORGI A, IPPOLITI R, DUPRE S, MARAS B. (2005). Glutathione S-transferase tissue profiling by reporter peptide monitoring. PROTEOMICS, vol. 5(3); p. 648-653, ISSN: 1615-9853, doi: 10.1002/pmic.200401061 I.F. 4.6
27. MARAS B., BARRA D, SCHININA ME, CARDONE F, POCCHIARI M. (2004). Prion (PrPres) allotypes profiling: a new perspectives from mass spectrometry. EUROPEAN JOURNAL OF MASS SPECTROMETRY, vol. 10(3); p. 371-382, ISSN: 1469-0667 I.F. 1.1
28. SCHININA ME, MARAS B., CARDONE F, MANCONE C, PRINCIPE S, DI BARI MA, PARCHI P, POCCHIARI M. (2003). Prion protein allotype profiling by mass spectrometry. PURE AND APPLIED CHEMISTRY, vol. 2-3; p. 317-323, ISSN: 0033-4545 I.F. 2.5
29. TROVATO M, CASAVOLA EC, MARAS B., SCHININA ME, COSTANTINO P, ASCENZI P (2003). Protein minimization: characterization of the synthetic cyclic dodecapeptide corresponding to the reactive site region of the oil rape trypsin inhibitor type-III. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 302; p. 311-315, ISSN: 0006-291X I.F 2.7
30. ANGIOLELLA L., MICOCCI MM., D'ALESSIO S., GIROLAMO A., MARAS B., CASSONE A. (2002). Identification of Major Glucan-Associated Cell Wall Proteins of Candida albicans and Their Role in Fluconazole Resistance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46; p. 1688-1694, ISSN: 0066-4804 I.F 4.7

FIRMATO

Bruno Maras