Catalogo dei Corsi di studio

Michele Migliore : Curriculum Vitae

Born in Palermo, March 21, 1957

Education: October 1980, University of Palermo; D. Phil. (Physics, Summa cum Laude)

Current positions

1998-present: Senior Research Scientist, National Research Council (CNR), Institute of Biophysics, Palermo (Italy).
2004-present: Visiting Research Scientist, Yale University School of Medicine, Dept. of Neuroscience, New Haven, USA.
2001-present: Visiting Professor of Cybernetics, University of Palermo, Dept. of Mathematics and Informatics, Palermo, Italy.
2018-present: Visiting Professor of Computational Neuroscience, University of Rome La Sapienza , Department of Neurobiology, Rome, Italy

Previous positions

1983- 1998: Research Scientist, Institute for Interdisciplinary Applications of Physics, CNR, Palermo (Italy).
1994-1995: Visiting Professor, Physics Dept. University of Palermo, Theory and Applications of artificial neural networks;
2002-2003: Visiting Professor, Informatics, University of Palermo, Dept. of Natural Sciences, Palermo, Italy.
2002-2004: Associate Research Scientist, Yale University School of Medicine, Dept. of Neurobiology (New Haven, USA).
2009- 2010: Research Fellow, Krasnow Institute of Advanced Study, George Mason University (Fairfax, USA).
2015 - 2017: Director s Delegate, National Research Council, Institute of Biophysics, Palermo Section (Italy)
2021- present: Research Director, National Research Council, Institute of Biophysics, Palermo Section (Italy)

Fellowships and Awards

1987: NATO Advanced Fellowship in Biophysics, IBM Research Centre (Kingston, NY, USA).
1997: NATO Senior Fellowship in Biotechnologies and Molecular Biology, Baylor College of Medicine (Houston, USA).
2007: DEISA (Distributed European Infrastructure for Supercomputing Applications) award for project LASIMOLF (Large scale realistic Simulations of the OLFactory bulb)
2012: PRACE (Partnership for Advanced Computing in Europe) award for project LSS-BULB, Large Scale Simulations of the olfactory BULB)
2014: PRACE award for project 3DBULB
2015: PRACE award for project SMOLER, Synaptic Mechanisms underlying Odor LEarning and Recognition
2016: PRACE award for project LACEHIP, LArge scale CEllular model of the HIPpocampus

Professional activities and Management assignments
National Coordinator: Research project Development, implementation and applications of new parallel architectures and concurrent algorithms for Transputers networks, 1990.
National Coordinator: Research project Development, implementation and modeling of neuronal networks, 1992.
National Coordinator: Research project Neuronal networks: biophysical modeling and applications, within the CNR Strategic Project on Neural Networks, 1993.
Member of Scientific Board, National Research Council - Institute for Interdisciplinary Applications of Physics, 1984-1988, 1988-1992, 1992-1996, 1996-1998.
Committee Member, National Research Council, Palermo Research Area, 1994-1997.
Editorial Board Member, International Journals: Computational and Mathematical Methods in Medicine, Hindawi Publishing Corporation; Computational Intelligence and Neuroscience, Hindawi Publishing Corporation.
Reviewer of proposals submitted to EU FP2,3,4, Biotechnology and Biological Sciences Research Council (UK), and Medical Research Council (UK); 1996- present.
Reviewer for many international journals, such as PNAS, J.Neurosci., J.Neurophysiol., Neural Comp., Eur. J. Neurosci., Biol. Cybern., J. Physiol., Neuroinformatics, PLOS journals, Frontiers Journals, and others.
Member of the Infrastructure Development Committee, Human Brain Project. EU
Member of the High-Level Support Team steering Committee, Human Brain Project, EU
CNR representative, Human Brain Project
Director s Delegate, National Research Council, Institute of Biophysics, Palermo Section (Italy), 2015 - 2017:

Past and ongoing international collaborations
IBM Research Center, Poughkeepsie, NY, USA. Collaboration with E. Clementi (1983);
Institut for Physikalischke Chemie, Aachen, Germany. Collaboration with A. Geiger. (1984);
Max Planck Institut fur Chemie, Mainz, Germany. Collaboration with K. Heinzinger. (1985);
Institute for Theoretical Physics, Santa Barbara, CA, USA. Collaboration with J.J. Hopfield. (1986);
IBM Research Center, Kingston, NY, USA. Collaboration with E. Clementi e G. Corongiu. (1988);
Baylor College of Medicine, Houston, TX, USA (1992-1996). Collaboration with D. Johnston;
Rutgers University, Center for Molecular and Behavioral Neuroscience, Newark, NJ, USA (1998). Collaboration with G. Buzsaki;
Norwegian University of Life Sciences, Aas, Norway (2009-2011); collaboration with Gaute Einevoll;
Feinberg School of Medicine, Northwestern University, Chicago, USA (2010-2012); collaboration with Gordon Shepherd Jr.
Krasnow Institute of Advanced Study, George Mason University, Fairfax, USA, (2004-2011); collaboration with G.A. Ascoli;
University College London, Department of Pharmacology, UK, Collaboration with Mala Shah;
University of Naples Federico II , Department of Neuroscience and Reproductive and Odontostomatological Sciences, collaboration with M. Taglialatela;
University of Naples Federico II , Department of Mathematics, Naples (Italy); collaboration with A. Marasco;
European Brain Research Institute, Roma (Italy), collaboration with Enrico Cherubini;
Yale University, Department of Neurobiology, New Haven, USA, Collaboration with Gordon Shepherd e Michael Hines;
CNRS, Institut de Pharmacologie Mole culaire et Cellulaire, Valbonne (FR), Helene Marie;
Otto-von-Guericke-Universität, Institute for Physiology, Magdeburg, collaboration with Volkmar Lessmann;
EPFL, Blue Brain Project, Lausanne, CH;
Hungarian Academy of Sciences, Institute of Experimental Medicine, collaboration with Szabolcs Kali;
Scuola Normale Superiore, Pisa, Italy, collaboration with Antonino Cattaneo

Most recent invited talks
Rockefeller University, New York, Mar. 2004;
Brain and Mind Institute, EPFL, Lausanne, Switzerland, May 2005;
Brain Science Institute, RIKEN, Tokyo, Sep. 2005;
Tokyo Institute of Technology, SIG meeting of the Japanase Neural Network Society, Sep. 2005;
International School for Advanced Studies, Trieste, Sep. 2005;
Joint meeting of Swedish and Italian Neuroscience Societies, Oct. 2005, Ischia;
Department of Pharmacology, University College London, London, Mar. 2006;
Department of Pharmacology, Oxford University, Oxford, UK, May 2006.
The NEURON simulation environment, SISSA, Trieste (Italy), Jan. 2007.
Dept. of Neurobiology, Yale University, New Haven, CT, USA, Nov.2008;
Dipartimento di Scienze Farmacologiche, Univ. di Cagliari, Dec. 2008.
Krasnow Institute of Advanced Study, George Mason University, Jan. 2009.
Norwegian University of Life Sciences, Oslo, Jan. 2009.
Center for Learning and Memory, University of Texas at Austin, Mar. 2010.
Norwegian University of Life Sciences, Oslo, Jul. 2010.
Department of Cellular-Molecular Physiological and Pharmacological Sciences University of Pavia, Pavia, Apr. 2011.
Italian Institute of Technology, Genova, 2011.
Annual Meeting of the Italian Physics Society, L'Aquila, Sep. 2011.
International Conference in celebration of the 60th anniversary of the publication of the Hodgkin-Huxley model of the action potential, Trinity College, Cambridge University, UK, Jul. 2012
International Conference on Biologically Inspired Cognitive Architectures, Palermo (Italy), Nov. 2012
XIII. Magdeburg International Neurobiological Symposium "Learning and Memory , Magdeburg, Feb. 2015
School of Brain Cells & Circuits Camillo Golgi , Erice (Italy), Dec 2015.
NeuroMath, Mathematical and Computational Neuroscience workshop, Cortona, Italy (2016)
International Workshop on Brain Inspired Computing, Cetraro, Italy (2017)
Okinawa Inst. of Science and Tech., Comput. Neuroscience Workshop, Okinawa, Japan (2017).
School of Brain Cells & Circuits Camillo Golgi , Erice, Italy (2017).
Conference Organization and Chairman, First annual Summit of the CIRPROT EU Project (2017)
HBP Curriculum Series; Neurobiology for non-specialists, Innsbruck, July 2017
XV Seminar on Software for Nuclear, Subnuclear and Applied Physics, Alghero, May 2018
7th International Summer School of Neuroengineering, Genova, June 2018
HBP School: The Brain Simulation Platform, Scientific Chair, Sep. 2018

Research Interests
Over the past 35 years Michele Migliore has been involved in the development and implementation of computational models of complex systems. The research focus has been on Monte Carlo and Molecular Dynamics simulations of water-biomolecules interaction and then on computational neuroscience, with the broad long-term goal to investigate, using realistic models and state of the art simulations techniques, the basic processes underlying the nervous system functions and dysfunctions. In close interdisciplinary collaboration with leading experimental laboratories, his lab has investigated neuronal networks and single neurons at different integration levels always closely related to the available experimental data. The primary current research interests are the mechanisms of learning and memory, synaptic integration, and ion channels function, in the attempt to link behavioral and dysfunctional processes with signal processing at the single neuron or network level.

Current External funding
Human Brain Project, EU FET Flagship
Work Package and Task leader
Co-Design Project 2, technical leader
Yale University, USA
Key personnel, Gordon Shepherd s Lab
Senselab Project, NIDCD, USA
Key personnel
CircProt Project, JPND, EU
Work Package Leader
Fondo Sociale Europeo, Programma Operativo Sicilia 2014-2020: Avviso 11/2017 rafforzare l occupabilita nel sistema della R&S e la nascita di spin off di ricerca in Sicilia
PI (Laboratory of Computational Neuroscience)

Publications (Apr 2022)
~7537 citations, h-index 44, i-10 index 92 (font: Google Scholar)

1. Bianchi D, Migliore R, Vitale P, Garad M, Pousinha PA, Marie H, Lessmann V, Migliore M. Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs. Biophys J. 2022 Feb 15;121(4):644-657. doi: 10.1016/j.bpj.2022.01.002.
2. Giacopelli G, Tegolo D, Migliore M. The role of network connectivity on epileptiform activity. Sci Rep. 2021 Oct 21;11(1):20792. doi: 10.1038/s41598-021-00283-w
3. Bologna LL, Smiriglia R, Curreri D, Migliore M. (2021) The EBRAINS NeuroFeatureExtract: An Online Resource for the Extraction of Neural Activity Features From Electrophysiological Data. Front Neuroinform. 26;15:713899. doi: 10.3389/fninf.2021.713899.
4. Vitale P, Salgueiro-Pereira AR, Lupascu CA, Willem M, Migliore R, Migliore M, Marie H. Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer s Disease, Frontiers in Aging Neuroscience 13:302 (2021).
5. Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW. Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiol. 2021 Apr 1;125(4):1501-1516. doi: 10.1152/jn.00015.2021
6. Coppolino, S., Giacopelli, G., Migliore, M. (2021) Sequence Learning in a Single Trial: A Spiking Neurons ModelBased on Hippocampal Circuitry, IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, in press. doi: 10.1109/TNNLS.2021.3049281
7. Giacopelli, G., Spera E., Tegolo, D., Migliore, M. (2021), On the structural connectivity of large-scale models of brain networks at cellular level, Nature Scientific Reports, 11, 4345 (2021). https://doi.org/10.1038/s41598-021-83759-z.
8. Giacopelli, G., Migliore, M., Tegolo, D. (2020). Graph-theoretical Derivation of Brain Structural Connectivity. Appl. Mat. Comput. 377, 125150
9. Shepherd GM, Hines ML, Migliore M, Chen WR, Greer CA. Predicting brain organization with a computational model: 50-year perspective on lateral inhibition and oscillatory gating by dendrodendritic synapses. J Neurophysiol. 2020 Aug 1;124(2):375-387. doi: 10.1152/jn.00175.2020.
10. McCauley JP, Petroccione MA, D'Brant LY, Todd GC, Affinnih N, Wisnoski JJ, Zahid S, Shree S, Sousa AA, De Guzman RM, Migliore R, Brazhe A, Leapman RD, Khmaladze A, Semyanov A, Zuloaga DG, Migliore M, Scimemi A. Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1. Cell Rep. 2020 Oct 13;33(2):108255. doi: 10.1016/j.celrep.2020.108255.
11. Lupascu CA, Morabito A, Ruggeri F, Parisi C, Pimpinella D, Pizzarelli R, Meli G, Marinelli S, Cherubini E, Cattaneo A, Migliore M. (2020) Computational Modeling of Inhibitory Transsynaptic Signaling in Hippocampal and Cortical Neurons Expressing Intrabodies Against Gephyrin, Front Cell Neurosci. 14:173.
12. Ecker A, Romani A, Sáray S, Káli S, Migliore M, Falck J, Lange S, Mercer A, Thomson AM, Muller E, Reimann MW, Ramaswamy S. Data-driven integration of hippocampal CA1 synaptic physiology in silico. Hippocampus. 2020 Nov;30(11):1129-1145. doi: 10.1002/hipo.23220.
13. Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H (2019) The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding, Cell Rep. 29(2):317-331.e5. doi: 10.1016/j.celrep.2019.08.103
14. Einevoll GT, Destexhe A, Diesmann M, Grün S, Jirsa V, de Kamps M, Migliore M, Ness TV, Plesser HE, Schürmann F. (2019) The Scientific Case for Brain Simulations, Neuron. 102(4):735-744. doi: 10.1016/j.neuron.2019.03.027.
15. Solinas SMG, Edelmann E, Leßmann V, Migliore M (2019) A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS Comput Biol 15(4): e1006975.
16. Katiuscia Martinello, Elisabetta Giacalone, Michele Migliore, David A. Brown and Mala M. Shah, (2019), The subthreshold-active KV7 current limits spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals to regulate neurotransmission., Nature Communications Biology 2: 145.
17. Shepherd GM, Marenco L, Hines ML, Migliore M, McDougal RA, Carnevale NT, Newton AJH,Surles-Zeigler M and Ascoli GA (2019), Neuron Names: A Gene and Property-Based Name Format, With Special Reference to Cortical Neurons. Front. Neuroanat. 13:25. doi: 10.3389/fnana.2019.00025
18. Migliore R, Lupascu CA, Bologna LL, Romani A, Courcol JD, Antonel S, Van Geit WAH, Thomson AM, Mercer A, Lange S, Falck J, Rössert CA, Shi Y, Hagens O, Pezzoli M, Freund TF, Kali S, Muller EB, Schürmann F, Markram H, Migliore M. (2018), The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow, PLoS Comp. Biol., 14(9):e1006423. doi: 10.1371/journal.pcbi.1006423
19. Cavarretta F, Burton SD, Igarashi KM, Shepherd GM, Hines ML, Migliore M., (2018) Parallel odor processing by mitral and middle tufted cells in the olfactory bulb, Nature Sci Rep. 16;8:7625. doi: 10.1038/s41598-018-25740-x
20. Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW, J (2017) Optimizing computer models of corticospinal neurons to replicate in vitro dynamics J. Neurophysiol. 117(1):148-162. doi: 10.1152/jn.00570.2016.
21. McDougal RA, Morse TM, Carnevale T, Marenco L, Wang R, Migliore M, Miller PL, Shepherd GM, Hines ML (2017) Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience J. Comput. Neurosci. 42(1):1-10. doi: 10.1007/s10827-016-0623-7. Epub 2016 Sep 15
22. V Breton-Provencher, K Bakhshetyan, D Hardy, R Bammann, F Cavarretta, M Snapyan, D Coté, M Migliore, and A Saghatelyan (2016) Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb, Nature Comm, 7:12659. doi: 10.1038/ncomms12659.
23. Cellot G, Maggi L, Di Castro MA, Catalano M, Migliore R, Migliore M, Scattoni ML, Calamandrei G, Cherubini E. (2016) Premature changes in neuronal excitability account for hippocampal network impairment and autistic-like behavior in neonatal BTBR T+tf/J mice, Nature Sci Rep. 6:31696; doi: 10.1038/srep31696
24. Cavarretta F, Marasco A, Hines ML, Shepherd GM and Migliore M (2016), Glomerular and mitral-granule cell microcircuits coordinate temporal and spatial information processing in the olfactory bulb, Front Comput Neurosci. 10:67; doi: 10.3389/fncom.2016.00067
25. Lupascu CA, Morabito A, Merenda E, Marinelli S, Marchetti C, Migliore R, Cherubini E and Migliore M (2016) A General Procedure to Study Subcellular Models of Transsynaptic Signaling at Inhibitory Synapses. Front. Neuroinform. 10:23. doi: 10.3389/fninf.2016.00023
26. Migliore R, De Simone G, Leinekugel X, Migliore M, (2016) The possible consequences for cognitive functions of external electric fields at power line frequency on hippocampal CA1 pyramidal neurons, Eur. J. Neurosci, doi: 10.1111/ejn.13325.
27. A Marasco, A De Paris, M Migliore, (2016) Predicting the response of olfactory sensory neurons to odor mixtures from single odor response, Nature Sci Rep. 6:24091.
28. Spera E, Migliore M, Unsworth D, Tegolo D, (2016) On the cellular mechanisms underlying working memory capacity in humans, Neural Network World 4:335-350. DOI: 10.14311/NNW.2016.26.019
29. Zhou S, Migliore M, Yu Y (2016) Odor experience facilitates the sparse coding of new odors in a large-scale olfactory bulb model, Front. Neuroanat. 10:10. doi: 10.3389/fnana.2016.00010
30. Enrico P, Migliore M, Spiga S, Mulas G, Caboni F, Diana M. (2016) Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective, Neuroscience. 17;322:195-207
31. Migliore M, Cavarretta F, Marasco A, Tulumello E, Hines ML, Shepherd GM. (2015) Synaptic clusters function as odor operators in the olfactory bulb, Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8499-504.
32. Migliore M, De Simone G, Migliore R. (2015) Effect of the initial synaptic state on the probability to induce long-term potentiation and depression, Biophys J. 108(5):1038-46.
33. Miceli F, Soldovieri MV, Ambrosino P, De Maria M, Migliore M, Migliore R, Taglialatela M. (2015) Early-Onset Epileptic Encephalopathy Caused by Gain-of-Function Mutations in the Voltage Sensor of Kv7.2 and Kv7.3 Potassium Channel Subunits, J. Neurosci. 35(9):3782-93.
34. Migliore M., McTavish T. (2015) Olfactory Computation in Mitral-Granule Cell Circuits. In: Jaeger D., Jung R. (Ed.) Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com). Springer New York, pp 2139-2142, DOI: 10.1007/978-1-4614-6675-8_615, ISBN 978-1-4614-6674-1.
35. Shepherd, GordonM. and Morse, ThomasM. and Marenco, Luis and Cheung, Kei and Carnevale, Ted and Migliore, Michele and McDougal, RobertA. and Hines, Michael and Miller, Perry (2015) SenseLab: Integration of Multidisciplinary Neuroscience Data, in: Jaeger D., Jung R. (Ed.) Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com). Springer New York, pp 2655-2657, DOI: 10.1007/978-1-4614-6675-8_497, ISBN 978-1-4614-6674-1.
36. Marasco A, Migliore M, (2015) Reduced Morphology Models. In: Jaeger D., Jung R. (Ed.) Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com). Springer New York, pp 2598-2610, DOI 10.1007/978-1-4614-6675-8_245; ISBN 978-1-4614-6674-1
37. Gasparini S., Migliore M. (2015) Action Potential Back-Propagation. In: Jaeger D., Jung R. (Ed.) Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), Springer New York, pp 133-137, DOI 10.1007/978-1-4614-6675-8_123; ISBN 978-1-4614-6674-1.
38. McDougal, Robert A, Wang, Rixin, Morse, Thomas M, Migliore, Michele, Marenco, Luis, Carnevale, Ted, Hines, Michael, and Shepherd, Gordon M. (2015) ModelDB, In: Jaeger D., Jung R. (Ed.) Encyclopedia of Computational Neuroscience: SpringerReference (www.springerreference.com), Springer New York, pp 1727-1730, 10.1007/978-1-4614-6675-8_158; ISBN 978-1-4614-6674-1.
39. Cavarretta F, Carnevale NT, Tegolo D and Migliore M (2014) Effects of low frequency electric fields on synaptic integration in hippocampal CA1 pyramidal neurons: implications for power line emissions. Front. Cell. Neurosci. 8:310
40. Yu Y, Migliore M, Hines ML, Shepherd GM (2014) Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition, J. Neurosci. 34: 13701-13713.
41. Casaleggio A, Hines ML, Migliore M. (2014) Computational model of erratic arrhythmias in a cardiac cell network: the role of gap junctions PLoS One. 9:e100288.
42. Migliore M, Cavarretta F, Hines ML, Shepherd GM. (2014) Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb, Front Comput Neurosci. 8:50.
43. Bianchi D, De Michele PD, Marchetti C, Tirozzi B, Cuomo S, Marie H, Migliore M (2014), Effects of increasing CREB-dependent transcription on the storage and recall processes in a hippocampal CA1 microcircuit, Hippocampus. 24:165-77.
44. Migliore M, Cavarretta F, Hines ML, Shepherd GM. (2013) Functional neurology of a brain system: a 3D olfactory bulb model to process natural odorants. Funct. Neurol. 28:241-3
45. Marasco A, Limongiello A, Migliore M (2013) Using Strahler's analysis to reduce up to 200-fold the run time of realistic neuron models, Nature Sci Rep. 3:2934
46. Yu Y, McTavish TS, Hines ML, Shepherd GM, Valenti C, Migliore M. (2013) Sparse Distributed Representation of Odors in a Large-scale Olfactory Bulb Circuit, PLoS Comput Biol. 9(3):e1003014.
47. F Miceli, MV Soldovieri, P Ambrosino, M Migliore, MR Cilio, and M Taglialatela, (2013) Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kv7.2 potassium channel subunits, Proc. Nat. Acad. Sci. USA, 110:4386-91.
48. Ferrante M, Migliore M, Ascoli GA (2013) Functional impact of dendritic branch point morphology, J. Neurosci., 33:2156-2165.
49. Romani A, Marchetti C, Bianchi D, Leinekugel X, Poirazi P, Migliore M, Marie H (2013) Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses, Front. Comput. Neurosci., 7:1.
50. Tigerholm J, Migliore M, Fransén E. (2013) Integration of synchronous synaptic input in CA1 pyramidal neuron depends on spatial and temporal distributions of the input. Hippocampus, 23:87-99
51. Suter BA, Migliore M, Shepherd GM. (2013), Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties, Cereb Cortex. 23:1965-77.
52. Marasco A, Limongiello A, Migliore M. (2012) Fast and accurate low-dimensional reduction of biophysically detailed neuron models, Nature Sci Rep. 2012;2:928.
53. Culmone V, Migliore M (2012) Progressive effect of beta amyloid peptides accumulation on CA1 pyramidal neurons: a model study suggesting possible treatments. Front. Comput. Neurosci. 6:52. doi: 10.3389/fncom.2012.00052
54. Migliore M, Migliore R. (2012) Know your current Ih: interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations, PLoS One. 2012;7(5):e36867.
55. Marcelin B, Liu Z, Chen Y, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram TZ, Esclapez M, Bernard C. (2012) Dorsal-ventral differences in intrinsic properties in developing CA1 pyramidal cells, J. Neurosci., 32:3736-3747.
56. Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M, (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons, J. Comp. Neurosci. 33:207-225.
57. Mctavish TS, Migliore M, Shepherd GM and Hines ML (2012) Mitral cell spike synchrony modulated by dendrodendritic synapse location Front. Comput. Neurosci. 6:3
58. Mala M Shah, Michele Migliore, and David A. Brown, (2011) Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons, J. Physiol. 589:6029-38.
59. Halnes G, Augustinaite S, Heggelund P, Einevoll GT, Migliore M (2011) A Multi-Compartment Model for Interneurons in the Dorsal Lateral Geniculate Nucleus PLoS Comp. Biol. 7:e1002160.
60. Migliore M, De Blasi I, Tegolo D, Migliore R (2011) A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior, Neural Networks, 24:552-559.
61. Migliore M, Hines ML, McTavish TS, Shepherd GM. (2010) Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb. Front. Integr. Neurosci. 4:122.
62. J.L. Baker, T. Perez-Rosello, M. Migliore, G. Barrionuevo, G.A. Ascoli. (2010) A computer model of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells. J. Comput. Neurosci., 31:137-58.
63. Morse TM, Carnevale NT, Mutalik PG, Migliore M and Shepherd GM (2010) Abnormal excitability of oblique dendrites implicated in early Alzheimer's: a computational study. Front. Neural Circuits 4:16.
64. Gordon M. Shepherd, Michele Migliore, and David C. Willhite, The Olfactory Bulb, in Handbook of Brain Microcircuits, ch.24, G. Shepherd and S. Grillner. Eds, Oxford University Press, (2010). ISBN 9780195389883
65. G. Ascoli, S. Gasparini, V. Medinilla, and M. Migliore. Local Control of Post-Inhibitory Rebound Spiking in CA1 Pyramidal Neuron Dendrites, J. Neurosci., 30: 6422-6433 (2010).
66. S. Spiga, A. Lintas, M. Migliore and M. Diana. Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence: pre and post synaptic elements, Addiction Biology, 15:266-76 (2010).
67. Victoria F. Safiulina, Maddalena D. Caiati, Sudhir Sivakumaran, Giacomo Bisson, Michele Migliore, Enrico Cherubini. Control of GABA release at single mossy fiber-CA3 connections in the developing hippocampus, Front. Syn. Neurosci., 2:1 doi:10.3389/neuro.19.001.2010 (2010).
68. M Migliore, DB Jaffe, GA Ascoli. CA3 Cells: detailed and simplified pyramidal cells models, in Hippocampal Microcircuits, ch.12, Springer Series in Computational Neuroscience, ISBN 978-1-4419-0995-4, (2010).
69. M. Ferrante, M. Migliore, G.A. Ascoli. Feed-forward inhibition as a buffer of the neuronal input-output relation. Proc. Natl. Acad. Sci. USA, 106:18004-18009 (2009).
70. F. Miceli, M.V. Soldovieri, L. Lugli, G. Bellini, P. Ambrosino, M. Migliore, E. Miraglia Del Giudice, F. Ferrari, A. Pascotto, M. Taglialatela, Neutralization Of a Unique, Negatively-charged Residue in the Voltage Sensor of KV7.2 Subunits in a Sporadic Case of Benign Familial Neonatal Seizures, Neurobiol. Dis., 34:501-510 (2009).
71. Peter Hemond, Michele Migliore, Giorgio A. Ascoli, and David B. Jaffe, The membrane response of hippocampal CA3b pyramidal neurons near rest: heterogeneity of passive properties and the contribution of hyperpolarization-activated currents, Neuroscience, 160:359-370 (2009).
72. Béatrice Marcelin, Laëtitia Chauvière, Albert Becker, Michele Migliore, Monique Esclapez, Christophe Bernard, h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy, Neurobiol. Dis., 33:436-47 (2009).
73. Migliore M, Novara G, Tegolo D (2008) Single neuron binding properties and the magical number 7, Hippocampus 18:1122-1130.
74. Ferrante M, Blackwell KT, Migliore M, Ascoli GA (2008), Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets, Current Medicinal Chemistry 15:2456-2471.
75. Mala M. Shah, Michele Migliore, Ignacio Valencia, Edward C. Cooper and David A. Brown, Functional Significance of Axonal Kv7 channels in Hippocampal Pyramidal Neurons, Proc. Nat. Acad. Sci. USA, 105:7869-7874 (2008).
76. Migliore M, Cannia, C, Canavier CC, A modeling study suggesting a possible pharmacological target to mitigate the effects of ethanol on reward-related dopaminergic signaling. J Neurophysiol., 99:2703-2707 (2008).
77. Peter Hemond, Daniel Epstein, Angela Boley, Michele Migliore, Giorgio A. Ascoli,and David B. Jaffe, Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b, Hippocampus, 18:411-424 (2008).
78. Cassarà AM, Hagberg GE, Bianciardi M, Migliore M, and Maraviglia B. Realistic Simulations of Neuronal Activity: A Contribution to the Debate on Direct Detection of Neuronal-currents by MRI, Neuroimage, 39:87-106 (2008).
79. Migliore M, Shepherd, Gordon M, Dendritic action potentials connect distributed dendrodendritic microcircuits. J. Comput. Neurosci., 24:207-221 (2008).
80. M. Migliore, Carlo Inzirillo and Gordon M. Shepherd, Learning mechanism for column formation in the olfactory bulb, Front. Int. Neurosci. 1:12 (2007).
81. Chiquito J. Crasto, Luis N. Marengo, Nian Liu, Thomas M. Morse, Kei-Hoi Cheung, Peter C. Lai, Gautam Bahl, Peter Masiar, Hugo Y.K. Lam, Ernest Lim, Huajin Chen, Prakash Nadkarni, Michele Migliore, Perry L. Miller, Gordon M. Shepherd, SenseLab: new developments in disseminating neuroscience information, Briefings in Bioinformatics, 8:150-162 (2007).
82. F. Minneci, M. Janahmadi, M. Migliore, N. Dragicevic, E. Cherubini, Signaling properties of stratum oriens interneurons in the hippocampus of transgenic mice expressing EGFP in a subset of somatostatin-containing cells, Hippocampus, 17:538-553 (2007).
83. Shepherd GM, Chen WR, Willhite D, Migliore M, Greer CA, The olfactory granule cell: From classical enigma to central role in olfactory processing, Brain Res. Rev. 55:373-382 (2007).
84. R. Bartesaghi, M. Migliore, T. Gessi, Input-Output relations in the Entorhinal cortex-Hippocampal system: evidence for a non-linear transfer of signals, Neuroscience,142:247-265 (2006).
85. M. Migliore, C. Cannia, W.W Lytton, Henry Markram, and M. L. Hines, Parallel Network simulations with NEURON, J. Comp. Neurosci. 21:119-129 (2006).
86. R. Shimazaki, A. Boccaccio, A. Mazzatenta, G. Pinato, M. Migliore, A. Menini, Electrophysiological properties and modeling of murine vomeronasal sensory neurons in acute slice preparations, Chem. Senses, 31:425-435 (2006).
87. Migliore M, Ferrante M, Ascoli GA, Signal propagation in oblique dendrites of CA1 pyramidal cells, J. Neurophysiol., 94:4145-55 (2005).
88. Migliore M., and Shepherd, Gordon M. An integrated approach to classifying neuronal phenotypes, Nature Rev. Neuroscience 6:810-18 (2005).
89. Saghatelyan A, Roux P, Migliore M, Rochefort C, Desmaisons D, Charneau P, Shepherd GM, and Lledo P-M, Activity-Dependent Adjustments of the Inhibitory Network in the Adult Olfactory Bulb Following Early Postnatal Deprivation, Neuron 46:103-116 (2005).
90. M Migliore, ML Hines, and Gordon M Shepherd, The role of distal dendritic gap junctions in synchronization of mitral cell axonal output, J. Comput. Neurosci. 18:151-161 (2005).
91. Gasparini S, Migliore M, Magee JC (2004) On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons, J. Neurosci. 24:11046-11056.
92. ML Hines, TM Morse, M. Migliore, NT Carnevale, and GM Shepherd, ModelDB: a database to support computational neuroscience, J. Comput. Neurosci. 17, 7-11 (2004).
93. M. Migliore, L. Messineo, M. Ferrante, Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons, J. Comput. Neurosci. 16, 5-13 (2004).
94. AP Davison, TM Morse, M Migliore, GM Shepherd, ML Hines, (2004) Semi-automated population of an online database of neuronal models (ModelDB) with citation information, using PubMed for validation, Neuroinformatics 2, 327-332
95. Chiquito J. Crasto, Luis Marenco, Michele Migliore, Buqing Mao, Prakash M. Nadkarni, Perry Miller and Gordon M. Shepherd. Text Mining Neuroscience Journal Articles to Populate Neuroscience Databases, Neuroinformatics, 3, 215-238 (2003).
96. Frick A, J. Magee, H.J. Koester, M. Migliore, and D. Johnston, Normalization of Ca2+ signals by small oblique dendrites of CA1 pyramidal neurons, J. Neurosci., 23, 3243-3250 (2003).
97. M. Migliore, On the integration of subthreshold inputs from Perforant Path and Schaffer collaterals in hippocampal CA1 neurons, J. Comput. Neurosci. 14, 185-192 (2003).
98. M. Migliore, TM Morse, AP Davison, L Marenco, GM Shepherd and ML Hines, ModelDB: making models publicly accessible to support computational neuroscience, Neuroinformatics 1, 135-140 (2003).
99. N.P. Poolos, M. Migliore, and D. Johnston, Pharmacological upregulation of h-channels selectively reduces the excitability of pyramidal neuron dendrites, Nature Neurosci. 5, 767-774 (2002).
100. S. Watanabe, DA Hoffman, M. Migliore, and D. Johnston, Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons, Proc. Natl. Acad. Sci. USA 99, 8366-8371 (2002).
101. M.T. Lazarewicz, M. Migliore, G.A. Ascoli, A new bursting model of CA3 pyramidal cell physiology suggests multiple locations for spike initiation, Biosystems 67, 129-137 (2002).
102. M. Migliore and Gordon M. Shepherd, Emerging rules for distributions of active dendritic conductances, Nature Rev. Neurosci. 3, 362-370 (2002).
103. Davison AP, Morse TM, Migliore M, Marenco L, Shepherd GM, and Hines ML. ModelDB: A Resource for Neuronal and Network Modeling. In: Neuroscience Database: A Practical Guide. Ed. Rolf Kotter. Kluwer Academic Publishers, Dusseldorf, pp: 99-109 (2002).
104. M. Migliore, L. Messineo, M. Cardaci, GF Ayala, Quantitative modeling of perception and production of time intervals, J. Neurophysiol. 86, 2754-2760 (2001).
105. S. Chillemi, R. Balocchi, M.Barbi, A. Di Garbo, R. Ferri, M. Migliore Early trends in Seizure onset: a Nonlinear Approach. In Mathematics and Computers in Science and Engineering C.E. D Attellis, V.V. Kluev, N.E. Mastorakis eds., 156-160, WSES (2001).
106. D. Johnston, D.A. Hoffman, J.C. Magee, N.P. Poolos, S. Watanabe, C.M. Colbert, and M. Migliore, Dendritic Potassium Channels in Hippocampal Pyramidal Neurons. J. Physiol. (Lond.), 525, 75 (2000).
107. M. Migliore, L. Messineo, M. Cardaci, The Subjective Estimate of Intervals: A Computational Model, Proc. of the 5th Joint Conference on Information Sciences, 27 Feb.- 3 Mar. Atlantic City, USA, p.871, (2000).
108. M. Migliore, D. Hoffman, J.C. Magee, and D. Johnston, Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal neurons. J. Comput. Neurosci., 7, 5, (1999).
109. M. Migliore and P. Lansky, Computational model of the effects of stochastic conditioning on the induction of Long-Term Potentiation and Depression, Biol. Cybern., 81, 291-8 (1999).
110. M. Migliore, L. Messineo, M. Cardaci, Modeling the effects of cognitive load on the calculation of elapsed time, Soc. Neurosci. Abs. 25, 1390, 1999.
111. M. Migliore and P. Lansky,Long-Term Potentiation and Depression induced by a stochastic conditioning of a model synapse, Biophys. J., 77, 1234-43 (1999).
112. M. Migliore and M. Culotta, Energy efficient modulation of dendritic processing functions, Biosystems, 48, 157-163 (1998).
113. M. Migliore and P. Lansky, The statistical variability of a conditioning input causes a dynamic shift of the LTD/LTP threshold in a model synapse, Soc. Neurosci. Abs. 24, 329 (1998).
114. T. Gessi, R. Bartesaghi, M. Migliore,Neuronal networks in the hippocampal region. II. Impulse transmission patterns, in Macromolecular Interplay in Brain Associative Mechanisms, A. Neugebauer Ed., World Scientific (New York), pp. 88 (1997).
115. M. Migliore and M.Culotta, On the possible mechanisms that could dynamically control the computational properties of CA1 neurons, Soc. Neurosci. Abs. 23, 225 (1997).
116. M. Migliore, F. Alicata, G.F. Ayala,Possible roles of retrograde messengers on LTP, LTD, and associative memory, Biosystems 40, 127-32 (1997).
117. M. Migliore,Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons, Biophys. J. 71, 2394-403 (1996).
118. M. Migliore, Models of activity-dependent changes in the backpropagated action potentials of CA1 neurons, Soc. Neurosci. Abs., 22 (1996).
119. M. Migliore, E. Cook, D.B. Jaffe, D.A. Turner and D. Johnston,Computer simulations of morphologically reconstructed CA3 hippocampal neurons, J. Neurophysiol. 73, 1157-68 (1995).
120. R. Bartesaghi, T. Gessi, M. Migliore,Input-Output relations in the entorhinal-hippocampal-entorhinal loop: entorhinal cortex and dentate gyrus, Hippocampus 5, 440-451 (1995).
121. M. Migliore, F. Alicata, G.F. Ayala, A model for Long-Term Potentiation and Depression, J. Comput. Neurosci. 2, 335 (1995).
122. M. Migliore, F. Alicata, G.F. Ayala, A computational model for the associative Long-Term Potentiation, Proc of IEEE Intl. Conf. on Neural Networks, Orlando (FL), 1994, p. 2264-2267.
123. M. Migliore, F. Alicata, G.F. Ayala, Long-Term Potentiation and Depression: a computer simulation, Proc of IEEE Intl. Conf. on Neural Networks, Orlando (FL), 1994, p. 2272-2275.
124. F. Alicata, M. Migliore, G.F. Ayala, A model for Associative LTP: roles of retrograde messengers, Soc. Neurosci. Abs. 20, 1433, 1994.
125. M. Migliore, F. Alicata, G.F. Ayala, Roles of retrograde signals in LTP and LTD: a computational model, Soc. Neurosci. Abs. 20, 1433, 1994.
126. F. Alicata, M. Migliore and S.L. Fornili,Monte Carlo evaluation of the hydration free energy for Hydronium, Hydroxyl and Ammonium ions, J. Mol. Liq. 58, 117 (1993).
127. M. Migliore, E. Cook and D. Johnston, A model for simulating the firing characteristics of CA3 and CA1 neurons, Soc. Neurosci. Abs. 19, 715 (1993).
128. M. Lapis and M. Migliore: ``Sistema Parallelo basato su Transputers per il controllo automatico e l'analisi in tempo reale di esperimenti neurofisiologici'', CNR, Tech. Rep. on project Sistemi Informatici e Calcolo Parallelo (1993).
129. M. Migliore, G.F. Ayala,A kinetic model of Short- and Long-Term Potentiation, Neural Comput. 5, 636 (1993).
130. M. Migliore, D. B. Jaffe and D. Johnston, Computer simulation of a CA3 hippocampal neuron, Soc. Neurosci. Abs. 18, 1503 (1992).
131. G.F. Ayala, M. Migliore, A model of Long-Term Potentiation, Soc. Neurosci. Abs. 18, 1494 (1992).
132. Bartesaghi R., Gessi T., Migliore M., Activation of dentate gyrus granule cells by differently elicited perforant path volleys. Eur. J. Neurosci., Suppl. 5 p.69 (1992).
133. Bartesaghi R., Gessi T., Migliore M., Entorhinal cortex-hippocampal formation loop: input-output relations in hippocampus. Neurosci. Lett. Suppl.43, S9 (1992).
134. Bartesaghi R., Gessi T., Migliore M. Transfer of impulse volleys along the entorhinal cortex - hippocampal formation - entorhinal cortex loop. Pflugers Arch. 421, 36 (1992).
135. M. Migliore, G.F. Ayala, S.L. Fornili,Concurrent simulations of neurons on multi-Transputer systems, Computers in Physics, Nov/Dec, 605 (1991).
136. M. Migliore, V. Martorana, F. Sciortino,An algorithm to find all paths between two nodes in a graph J. Comput. Phys. 87, 231 (1990).
137. E. Clementi, S. Chin, G. Corongiu, J. Given, G.C. Lie, M. Migliore, P. Procacci, Supercomputer simulation of the interaction of biomolecules in solution, Proc. of Symposia in Pure Mathematics 50, 213 (1990).
138. M. Migliore, A program for exhaustive graph search on vector and parallel computers, CNR, Tech. Rep. 1/24 on project Sistemi Informatici e Calcolo Parallelo (1990).
139. M.Migliore, G.F. Ayala and S.L. Fornili: "Modeling of neuronal systems on Transputer networks", in Parallel Processing in Neural Systems and Computers, p.291, R. Eckmiller, G. Hartmann, G. Hauske Eds., Elsevier, 1990.
140. R. Noto, V. Martorana, M. Migliore and S.L. Fornili,Hydration of the Ammonium ion: Monte Carlo simulation, Z. Naturforsch. 46a, 107 (1990).
141. Bartesaghi R., Gessi T., Migliore M., Impulse transmission patter in the Hippocampus: Entorhinal cortex loop, Proc. of the Meeting Biochemical Engrams of memory, Verona (Italy), Aug-29-31 (1992).
142. G. Corongiu, M. Migliore and E. Clementi, Hydration free energy for Li+ at infinite dilution with a 3-body abinitio potential, J. Chem. Phys. 90, 4629 (1989).
143. R. Noto, M. Migliore, F. Sciortino and S.L. Fornili,Solute-induced water structure: computer simulation on a model system, Molec. Simul. 1, 225 (1988).
144. M. Migliore, G. Corongiu, E. Clementi and G.C. Lie,Monte Carlo study of Free energy for hydration of Li+, Na+, K+, F- and Cl- with ab-initio Potentials, J. Chem. Phys. 88, 7766 (1988).
145. F. Bruge', V. Martorana, M. Migliore and S.L. Fornili: ``Concurrent processing on transputer arrays", Mem. S.A.It. 59, 479 (1988).
146. G. Andaloro, M.A. Palazzo, M. Migliore, and S.L. Fornili, Hydration of Hydroxyde ion: ab-initio calculations and Monte Carlo simulation, Chem. Phys. Lett. 149, 201 (1988).
147. M. Migliore, G. Corongiu, E. Clementi and G.C. Lie, Free energy for hydration of Li+, Na+, K+, F- and Cl- with ab-initio Potentials, IBM Technical report KGN-165, Kingston NY, 1987.
148. S.L. Fornili, V. Martorana and M. Migliore. The Transputer in statistical simulation: results of a test, Inf. Quaterly of CCP5, June 1987.
149. V. Martorana, M. Migliore and S.L. Fornili. Molecular dynamics simulation of Lennard-Jones systems: parallel implementations on transputer arrays, Proc. of VII OCCAM user group and Int'l workshop on Parallel Programming of Transputer-based machines. Grenoble, France 1987.
150. M. Migliore, S.L. Fornili, E. Spohr and K. Heinzinger,Molecular dynamics study of a KCl aqueous solution: dynamical results, Z. Naturforsch. 42a, 227 (1987).
151. M. Leone, F. Sciortino, M. Migliore, S.L. Fornili and M.B. Palma-Vittorelli,Order parameters of gels and gelation kinetics of aqueous Agarose systems: relation to the spinodal decomposition of the sol, Biopolymers 26, 743 (1987).
152. S.L. Fornili, M. Migliore and M.A. Palazzo, Hydration of hydronium ion: ab initio calculations and Monte Carlo simulation, Chem. Phys. Lett. 125, 419 (1986).
153. M. Migliore, S.L. Fornili, E. Spohr, G. Palinkas and K. Heinzinger,A molecular dynamics study of the structure of an aqueous KCl solution, Z.Naturforsch. 41a, 826 (1986).
154. S.L. Fornili, M. Migliore and M.A. Palazzo, Water-hydronium interaction: a computer simulation. in Biomolecular Stereodynamics vol.III, 253 (1986), Albany,N.Y.
155. S.L. Fornili, M. Migliore, D.P. Vercauteren and E. Clementi,Monte Carlo simulation of water interaction with Gramicidin A transmembrane channel: hydrogen bond analysis, Journal de Physique 45, C7-219 (1984).
156. S.L. Fornili, M. Leone, F. Madonia, M. Migliore, M.B. Palma-Vittorelli, M.U. Palma and P.L. San Biagio,Biomolecular-solvent stereodynamic coupling probed by deuteration, J. Biomol. Str. Dyn. 1, 473 (1983).
157. M. Migliore, M. Leone and M.B. Palma-Vittorelli:``Cinetiche di ordinamento sopramolecolare: simulazioni e risultati sperimentali.", Proc. of VI Congresso SIBPA, Camogli, Italy, 6-8 Oct. 1983.
158. S.L. Fornili and M. Migliore, Microcomputer-based system for automation of spectrophotometric data acquisition for long-lasting kinetics, J. Phys. E: Sci. Instrum. 14, 426 (1981).