Catalogo dei Corsi di studio

PERSONAL INFORMATION
Position: Full Professor of Biochemistry SSD Bio/10
Institution: Sapienza University of Rome, Dept. Biochemical Sciences
Faculty: Pharmacy and Medicine,
ORCID:orcid.org/0000-0002-5991-5868
H index: 43 (Scopus)
Publications: 126 articles in international refereed Journals("corresponding author" in 49 of them) https://www.ncbi.nlm.nih.gov/pubmed/?term=mangoni+ml

EDUCATION
1996: Degree in Biology with honours from Sapienza University of Rome, 1996.
2003: Ph.D. in Biochemistry, Sapienza University.

SCIENTIFIC AND PROFESSIONAL EXPERIENCE
Present: Full Professor. Group Leader in the Antimicrobial Peptides Lab.
2012-August 2020- Associate Professor of Biochemistry, Sapienza University
2002-2012-Assistant Professor of Biochemistry, same University
1999: Research fellow, University G. D annunzio, Chieti, Italy
1998: Research fellow at the Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden, under the supervision of Prof. Hans G. Boman.

SCIENTIFIC INTERESTS
More than 25-year experience in the field of AMPs: (i)Functional characterization of antimicrobial peptides (AMPs) from amphibian skin secretions; (ii) Development of experimental procedures to determine their antibacterial, antifungal, antiparasitic and cytolytic activities;)(iii) Mechanism of action of membrane-active AMPs on artificial and biological systems by means of biochemical and biophysical techniques; (iv) Studies on the role of AMPs in innate immunity, (v) Development of amphibian peptides as potential drugs. See http://www.marialuisamangoni.it/)

RESEARCH GRANTS
2005-2007: Local Team Coordinator for the PRIN Project 2005062410_004 "Evaluation of the antimicrobial activity and mechanism of action of natural peptides for a potential therapeutic usage" funded by MIUR

2008-10: National Coordinator of the PRIN Project 2008KCLR7M "Structure-function relationships and mechanism of action of natural and synthetic antimicrobial peptides in the defense against antibiotic-resistant pathogens and LPS-induced shock" funded by MIUR

2011-2013: PI of FFC#14/2011 Project: "Development of new host defence like peptides and lipopeptides against lung pathogens: in vitro and in vivo studies funded by the Italian Cystic Fibrosis Foundation

2012: PI of the Project "Development of short-sized native peptides and their synthetic analogues for the treatment of mucosal surfaces-associated infections " funded by Sapienza University

2013: PI of the Project " Antimicrobial peptides as novel strategies for treatment of lung bacterial infections and development of inhalable dry podwers" funded by Sapienza University

2014-16: PI of the Project Fighting microbial infections: a multidisciplinary strategy to develop short-sized native peptide-based antimicrobials" FUNDED BY ISTITUTO PASTEUR CENCI- BOLOGNETTI"

2014-16: PI of the Project " Development and preclinical testing of a novel antimicrobial peptide to treat Pseudomonas aeruginosa-induced lung infections " funded by the ITALIAN CYSTIC FIBROSIS FOUNDATION

2014: PI of the Project ""Derivatives of naturally-occurring peptides as novel drugs for treatment of P. aeruginosa lung infections: in vitro studies and preclinical testing" funded by Sapienza University

2016: PI of the Project "Derivatives of naturally-occurring peptides for the development of novel antibiotic therapy against lung infections " funded by Sapienza University

2017: PI of the Project " Frog skin-derived peptides for treatment of Pseudomonas aeruginosa lung infection and bronchial epithelial repair: advanced in vitro and in vivo characterization and development of polymeric nanoparticles for lung delivery" funded by the ITALIAN CYSTIC FIBROSIS FOUNDATION

2018-20: PI of the Project Development of novel peptide-based formulations and nano/bio-materials against pulmonary and ocular surface microbial infections" FUNDED BY ISTITUTO PASTEUR CENCI-BOLOGNETTI"

2018: PI of the Project "Novel peptide-based therapeutic approaches for treatment of bacterial pulmonary infections" funded by Sapienza University of Rome

2019-21: PI of the Project Antimicrobial peptides from amphibian skin for treatment of lung pathology in cystic fibrosis: advanced in vitro and in vivo functional characterization, funded by the ITALIAN CYSTIC FIBROSIS FOUNDATION

2019: PI of the Project Amphibian skin-derived peptides as novel tools against drug-resistant respiratory microbial and viral strains in elderly and cystic fibrosis patients funded by Sapienza University of Rome

2022-2023: Small multifunctional membrane-active peptides to tackle drug resistant respiratory and wound infections: advances in delivery systems and in vivo efficacy funded by Istituto Pasteur Italia-Fondazione Cenci Bolognetti"

2022-2024: Esculentin-derived peptides as novel therapeutic agents with antimicrobial and CFTR potentiator activities toaddress cystic fibrosislung disease funded by Fondazione Italiana per la ricerca sulla fibrosi cistica

PARTICIPANTS TO THE FOLLOWING PROJECTS:

-PE13 (PNRR) Project:Emerging Infectious diseases. Title: "One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases". Sapienza PI: Prof. Alessandra della Torre Sapienza. Finanziato dal Ministero Italiano Università e Ricerca. Co-PI Spoke 3: Prof. Alessandra Carattoli. PE13321852BEB81FF (2022-2026)

-Rome Technopole Flagship 7: Advances and automated innovation labs for diagnostic and therapeutic biopharma solutions . PI: Prof. Cristina Limatola. Co-PI Prof. Bruno Botta. Finanziato dal Ministero Italiano Università e Ricerca RT72218451D366F5 (2022-2026). 375.000 Eu

-COST Action CA21145 EURESTOP. European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (2022-2026)

PATENTING ACTIVITY
US patent n. 10059752. Title of invention: Esculentin 1A derivatives and uses thereof
Co-inventors: AM. McDermott (Houston University), M. L. Mangoni (Sapienza University)
Continuation in Part CIP of US patent- US N. 16/912944
International Pending Patent filed at Sapienza University (application N. 102019000018938). Ownership: Sapienza University (50%); Fondazione per la Ricerca sulla Fibrosi cistica - onlus (25%) and Istituto G. Gaslini (25%). Title: USE OF ESCULENTIN AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS. Inventors Maria Luisa MANGONI, Loretta FERRERA

AWARDS AND HONORS
2001: McGraw Hill Award for the best scientific work of young scientists (SIB Congress)
2011: Atomium Culture selection for publication of an article in the main European newspapers
From 2016 to 2022: MEMBER OF THE SCIENTIFIC COMMITTEE OF THE ITALIAN PEPTIDE SOCIETY
From 2018: NATIONAL REPRESENTATIVE OF ITALY AT THE EUROPEAN PEPTIDE SOCIETY (EPS COUNCIL)
From 2022: PRESIDENT OF THE ITALIAN PEPTIDE SOCIETY

TEACHING/MENTORSHIP OF DEGREE AND DOCTORAL DISSERTATIONS
From 2003: (i) Lecturer of Biochemistry in the Health Care Profession Courses (Degree courses in Nursing; Prevention Techniques in the Environment and in the Workplace; Psychiatric Rehabilitation Technique; (ii) Tutor of Degree Theses in Biology and of Ph.D. Theses in Biochemistry;

2009-2019: Member of the Board of Examiners for awarding the Ph.D in Biochemistry/Neuroscience/Molecular Biomedicine/Biophysics at National Universities, University College of Dublin and University of Split, CROATIA

From 2003: (i) Reviewer of Ph.D. Thesis presented at University of Melbourne, AUSTRALIA/University of Stellenbosch, SOUTH AFRICA/ University of New South Wales, SYDNEY AUSTRALIA/ University of Calcutta, INDIA

2012-2013: Member of the Teaching Board of Doctoral School in Pasteurian Sciences;
From 2013: Member of the Teaching Board of Doctoral School in Biochemistry, Sapienza University of Rome

EDITORIAL ACTIVITIES
2015-2017: Section Editor of Biochimica et Biophysica Acta-Biomembranes;
From 2015: Associate Editor of Frontiers in Biological Chemistry
From 2019: Editorial Board Member of BBA-Biomembranes and SECTION EDITOR of Antibiotics
From 2016: Section Editor of Current Protein & Peptide Science and Protein and Peptide Letters
From 2005: Referee activity for a large number of international peer-reviewed journals

REFEREE ACTIVITY FOR RESEARCH PROJECTS FUNDED BY
National Science Foundation (2004); Canadian Light Source (2007); Austrian Science Fund (2014); Murdock College Research Program for Natural Sciences (2017); ERC Advanced Grant (2019); The French Government in partnership with the Agence Nationale de la Recherche (2020)

INVITED GUEST EDITOR for a special issue
2009 Amphibian Antimicrobial Peptides for Biochimica et Biophysica Acta-Biomembranes;
2011 Host-defence peptides: from biology to therapeutic strategies for Cellular and Molecular Life Sciences
2016 Antimicrobial Peptides in Medicinal Chemistry: Advances and Applications" for Current Topics in Medicinal Chemistry
2019 Peptide nanomaterials for drug delivery applications for Current Protein and Peptide Science
2020 Amphibian antimicrobial peptides for Antibiotics
2021 "Secondary Metabolites and Peptides as Unique Natural Reservoirs of New Therapeutic Leads for Treatment of Cancer and Microbial Infections" to be published in Frontiers, section Chemical Biology

INVITED GUEST FOR SEMINARS ABROAD
Karolinska Institutet, Stockholm, 2000; Karlsruhe Institute of Technology, Germany, 2009; The Fraunhofer Institute for Biomedical Engineering IBMT, Potsdam, Germania, 2011; University of Manchester Medical School, Manchester, UK, 2014; University of Graz, Austria , 2018; University of Split, Croatia, 2019.

INVITED SPEAKER AT MOST RELEVANT CONFERENCES
2005:The V Gordon Research Conference on Antimicrobial Peptides, Ventura, CA. USA.
2006:The 2nd International Congress on Natural Peptides to drugs, Zermatt, Switzerland
2007: The 51st Annual Meeting of the American Biophysical Society, Baltimore, MD, USA.
2007:The VI Gordon Research Conference on Antimicrobial Peptides, il Ciocco, (Lu) Italy
2008:The 1st Italy-Korea Symposium on Antimicrobial Peptides, Gwangju-Korea
2008: The 30th European Peptide Symposium, Helsinki, Finland
2012: 56th National Meeting of the Italian Society of Biochemistry and Molecular Biology, Chieti (Italy)
2013:The IX Gordon Research Conference on Antimicrobial Peptides, Ventura, CA, USA
2014: The 3rd International Conference on Antimicrobial Research, Madrid, Spain.
2016:International Regulatory Peptide Society, Rouen, France.
2016: Institut Pasteur International Network. From Basic Science to Biomarkers & Tools in Global Health Scientific Symposium, Paris, France
2017:"Boulder Peptide Symposium . Boulder, Colorado (USA)
2018:World Ophthalmology Congress 2018, Barcelona, Spain
2018:XV Congress of the Italian Federation of Life Sciences (FISV), Rome
2019: Gordon Research Conference on Antimicrobial Peptides (Lucca)
2022: 7 International Antimicrobial peptides Symposium, Parigi, Francia, 7-9 Novembre. Title: Bioactive peptides from Esculentin-1a: from discovery towards 2022:European Peptide Symposium, Sitges (Barcelona), Spain, 28 Agosto-Septtembre 2. Titolo: Esculentin-1a derived diastereomers to address Pseudomonas aeruginosa lung infection in cystic fibrosis: from nature to bench towards therapeutic application. strategies to prevent and treat Pseudomonas aeruginosa lung and ocular surface infections

MEMBER OF ORGANIZING COMMITTEE FOR THE FOLLOWING INTERNATIONAL CONFERENCES
2010: First International Conference on Antimicrobial Research, Valladolid, Spain
2012: Second International Conference on Antimicrobial Research, Lisbon, Portugal
2018: V International Conference on Antimicrobial Research, Torremolinos Málaga,Spain
2018: 35th European Peptide Symposium, Dublin, Irland
2019: 9th International Meeting on Antimicrobial Peptides, Utrech, The Netherlands

INVITED CHAIR FOR THE FOLLOWING INTERNATIONAL CONFERENCES
2006: 2nd International Congress Natural Peptides to Drugs, Zermatt, Swizerland
2012: 2nd New Antimicrobials Workshop, Trieste, Italy
2014: 3rd International Conference on Antimicrobial Research, Madrid, Spain
2018:35th European Peptide Symposium Dublin, Irland
2019:9th International Meeting on Antimicrobial Peptides, Utrecht, The Netherlands