SASO LUCIANO

Professore Associato 
Settore scientifico disciplinare di riferimento  (BIO/14)
Ateneo Università degli Studi di ROMA "La Sapienza" 
Struttura di afferenza Dipartimento di FISIOLOGIA E FARMACOLOGIA "VITTORIO ERSPAMER" 
Recapiti Elenco recapiti telefonici
E-Mail Luciano.Saso@uniroma1.it

Orari di ricevimento

Tutti i giorni previo appuntamento da concordare via mail

Curriculum

CURRICULUM DIDATTICO-SCIENTIFICO DI LUCIANO SASO
POSIZIONE ATTUALE
Professore Associato della Facoltà di Farmacia e Medicina
Prorettore alle Reti Universitarie Europee e Coordinatore Istituzionale Erasmus, Sapienza Università di Roma per il periodo 2014-2020
Presidente della Rete UNICA delle Università delle Capitali Europee (http://www.unica-network.eu/) per il periodo 2016-2019
ATTIVITA’ DIDATTICA
2002-2004, Titolare del Corso di Farmacologia e Farmacoterapia, Corso di Laurea in Farmacia, M-Z), Sapienza Università di Roma.
Dal 1999, Titolare dei Corsi di Saggi e Dosaggi Farmacologici (Annuale con esercitazioni, 8 CFU, Corso di Laurea in CTF) e Biotecnologie Farmacologiche (semestrale, 4 CFU, Corso di Laurea in CTF) presso la Facoltà di Farmacia e Medicina di Sapienza Università di Roma.
Dal 2010, Titolare del modulo di Biotecnologie Farmacologiche (3 CFU, Corso di Laurea in Biotecnologie Farmaceutiche) presso la Facoltà di Farmacia e Medicina di Sapienza Università di Roma.
Dal 2017, Titolare del modulo di Terapie Molecolari (2 CFU, Corso di Laurea in Biotecnologie Mediche) presso la Facoltà di Farmacia e Medicina di Sapienza Università di Roma.
Dal 2001, Titolare del Corso di Bioetica (Scuola di Specializzazione in Farmacia Ospedaliera, Facoltà di Farmacia e Medicina, Sapienza Università di Roma)
ATTIVITA’ SCIENTIFICA
• Coordinatore del progetto di ricerca “Development of Novel Antioxidant Drugs” in collaborazione con l’Università di New Delhi (India) finanziato dal Ministero dell’Università e della Ricerca, Direzione Generale per le Strategie e lo Sviluppo dell’Internazionalizzazione della Ricerca Scientifica e Tecnologica previo parere favorevole del Ministero degli Affari Esteri, Direzione Generale per la Promozione e la Cooperazione Culturale.
• Coordinatore Scientifico dei progetti “Leonardo da Vinci” UNIPHARMA-GRADUATES (50 stages di 24 settimane per giovani laureati in chimica, biologia, farmacia e biotecnologie presso centri di ricerca europei ( www.unipharmagraduates.it)
• Coordinatore del progetto di ricerca INTAS 03-51-4813 in collaborazione con il Belozersky Institute of Physico-Chemical Biology of the Moscow State University, la Russian Academy of Sciences (Moscow), il Department of Biochemistry of the Belarus State University (Minsk, Belarus), il Department of Biotechnology of Lund University (Sweden) e l’Institut National de la Recherche Agronomique” (Nantes, France).
• Coordinatore del progetto di ricerca NATO Collaborative Linkage Grant N° 979533 in collaborazione con il Belozersky Institute of Physico-Chemical Biology, Moscow State University, il Department of Polymer Chemistry of the Moscow State University, la School of Biology of the Belarus State University (Minsk, Belarus) e il Department of Biotechnology of Lund University (Sweden)
Referee per le seguenti riviste internazionali:
Acta Biochimica et Biophysica Sinica
Anti-Cancer Agents in Medicinal Chemistry
Applied Biochemistry and Biotechnology
Asian Chemistry Letters
Asian Journal of Andrology
Biochimica et Biophysica Acta
Biotechnology and Bioengineering
Carbohydrate Research
Cell Biology International
Clinica Chimica Acta
Clinical Biochemistry
Clinical Chemistry
Current Medicinal Chemistry
Environment International
European Journal of Neuroscience
Experimental Biology and Medicine
Febs Journal (European Journal of Biochemistry)
Food and Chemical Toxicology
Free Radical Research
IUBMB Life
Journal of Agricultural and Food Chemistry
Journal of Andrology
Journal of Chromatography
Journal of Electroanalytical Chemistry
Journal of Molecular Catalysis B: enzymatic
Journal of Nutritional Biochemistry
Journal of Pharmacy and Pharmacology
Medical Science Monitor
Molecular and Cellular Biochemistry
Neurochemistry international
Neuroscience Letters
Pharmacological Research
Physical and Chemical News
Protein and Peptide Letters
Reproduction, Fertility and Development
Rheumatology Online
The Protein Journal
Theriogenology
Guest Editor per numerosi Special Issues nel suo settore di ricerca tra cui: Modulation of Oxidative Stress: Pharmaceutical and Pharmacological Aspects published in the journal Oxidative Medicine and Cellular Longevity in 2016, "Oxidative Stress as a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity" published in the journal Current Topics in Medicinal Chemistry in 2014, "Synthesis, evaluation and pharmacological applications of antioxidants" published in the journal Curr Med Chem in 2013, "Antioxidant heterocyclic compounds in drug discovery and medicinal chemistry" published in the journal Mini reviews in medicinal chemistry in 2013, "Chemistry and biology of antioxidants" published in The Journal of Pharmacy and Pharmacology in 2007.

PUBBLICAZIONI SCIENTIFICHE
Luciano Saso svolge attività di ricerca prevalentemente nel settore della modulazione farmacologica dello stress ossidativo. Dal 1989 ha pubblicato 196 articoli scientifici su riviste internazionali (PubMed) per un IF totale superiore a 500 e h-index-Scopus = 31 (h-index Google Scholar = 39).

1: Catapano MC, Karlíčková J, Tvrdý V, Sharma S, Prasad AK, Saso L, Chhillar AK,
Kuneš J, Pour M, Parmar VS, Mladěnka P. Mono and dihydroxy coumarin derivatives:
Copper chelation and reduction ability. J Trace Elem Med Biol. 2018 Mar;46:88-95.
doi: 10.1016/j.jtemb.2017.11.014. Epub 2017 Nov 27. PubMed PMID: 29413115.

2: Saso L, Korkina L, Zarkovic N. Modulation of Oxidative Stress: Pharmaceutical
and Pharmacological Aspects 2017. Oxid Med Cell Longev. 2017;2017:4802824. doi:
10.1155/2017/4802824. Epub 2017 Dec 17. PubMed PMID: 29391925; PubMed Central
PMCID: PMC5748130.

3: Kancheva VD, Slavova-Kazakova AK, Angelova SE, Kumar P, Malhotra S, Singh BK,
Saso L, Prasad AK, Parmar VS. Protective effects of new antioxidant compositions
of 4-methylcoumarins and related compounds with DL-α-tocopherol and L-ascorbic
acid. J Sci Food Agric. 2018 Jan 18. doi: 10.1002/jsfa.8892. [Epub ahead of
print] PubMed PMID: 29344958.

4: Loubidi M, Jouha J, Tber Z, Khouili M, Suzenet F, Akssira M, Erdogan MA, Köse
FA, Dagcı T, Armagan G, Saso L, Guillaumet G. Efficient synthesis and first
regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and
their evaluation in H(2)O(2)-induced oxidative stress. Eur J Med Chem. 2018 Feb
10;145:113-123. doi: 10.1016/j.ejmech.2017.12.081. Epub 2017 Dec 27. PubMed PMID:
29324335.

5: Applova L, Veljovic E, Muratovic S, Karlickova J, Macakova K, Zavrsnik D, Saso
L, Duric K, Mladenka P.
9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a Potentially Novel
Antiplatelet Drug which Antagonizes the Effect of Thromboxane A2. Med Chem. 2018
Feb 6;14(2):200-209. doi: 10.2174/1573406413666171010102535. PubMed PMID:
29032760.

6: Grewal GK, Kukal S, Kanojia N, Madan K, Saso L, Kukreti R. In Vitro Assessment
of the Effect of Antiepileptic Drugs on Expression and Function of ABC
Transporters and Their Interactions with ABCC2. Molecules. 2017 Sep 29;22(10).
pii: E1484. doi: 10.3390/molecules22101484. PubMed PMID: 28961159.

7: Kancheva VD, Slavova-Kazakova AK, Angelova SE, Singh SK, Malhotra S, Singh BK,
Saso L, Prasad AK, Parmar VS. Protective effects of 4-methylcoumarins and related
compounds as radical scavengers and chain-breaking antioxidants. Biochimie. 2017
Sep;140:133-145. doi: 10.1016/j.biochi.2017.07.010. Epub 2017 Jul 25. PubMed
PMID: 28751215.

8: Menezes JCJMDS, Edraki N, Kamat SP, Khoshneviszadeh M, Kayani Z, Mirzaei HH,
Miri R, Erfani N, Nejati M, Cavaleiro JAS, Silva T, Saso L, Borges F, Firuzi O.
Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents:
Selective Induction of Apoptosis in Cancer Cells. J Agric Food Chem. 2017 Aug
23;65(33):7228-7239. doi: 10.1021/acs.jafc.7b01388. Epub 2017 Aug 8. PubMed PMID:
28718636.

9: Gurer-Orhan H, Ince E, Konyar D, Saso L, Suzen S. The Role Of Oxidative Stress
Modulators In Breast Cancer. Curr Med Chem. 2017 Jul 11. doi:
10.2174/0929867324666170711114336. [Epub ahead of print] PubMed PMID: 28699501.

10: Ganesan D, Al-Sayed E, Albert A, Paul E, Singab ANB, Govindan Sadasivam S,
Saso L. Antioxidant activity of phenolic compounds from extracts of Eucalyptus
globulus and Melaleuca styphelioides and their protective role on
D-glucose-induced hyperglycemic stress and oxalate stress in NRK-49Fcells. Nat
Prod Res. 2017 Jun 21:1-7. doi: 10.1080/14786419.2017.1343324. [Epub ahead of
print] PubMed PMID: 28637361.

11: Graziani M, Sarti P, Arese M, Magnifico MC, Badiani A, Saso L. Cardiovascular
Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial
Effects of Modulators of Oxidative Stress. Oxid Med Cell Longev.
2017;2017:3034245. doi: 10.1155/2017/3034245. Epub 2017 May 16. Review. PubMed
PMID: 28593024; PubMed Central PMCID: PMC5448156.

12: Moosavi F, Hosseini R, Rajaian H, Silva T, Magalhães E Silva D, Saso L,
Edraki N, Miri R, Borges F, Firuzi O. Derivatives of caffeic acid, a natural
antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic
agents. Bioorg Med Chem. 2017 Jun 15;25(12):3235-3246. doi:
10.1016/j.bmc.2017.04.026. Epub 2017 Apr 27. PubMed PMID: 28495385.

13: Boldrini P, Fusco A, Nicoletti F, Badiani A, Saso L. Potential use of
modulators of oxidative stress as add-on therapy in patients with anxiety
disorders. Curr Drug Targets. 2017 Apr 25. doi:
10.2174/1389450118666170425153356. [Epub ahead of print] PubMed PMID: 28443504.

14: Milkovic L, Zarkovic N, Saso L. Controversy about pharmacological modulation
of Nrf2 for cancer therapy. Redox Biol. 2017 Aug;12:727-732. doi:
10.1016/j.redox.2017.04.013. Epub 2017 Apr 8. Review. PubMed PMID: 28411557;
PubMed Central PMCID: PMC5393166.

15: Joshi R, Rohil V, Arora S, Manral S, Kumar A, Goel S, Priya N, Singh P,
Ponnan P, Chatterji S, Dwarakanath BS, Saluja D, Rawat DS, Prasad AK, Saso L,
Kohli E, DePass AL, Bracke ME, Parmar VS, Raj HG. Corrigendum to The Competence
of 7,8-Diacetoxy-4-Methylcoumarin and Other Polyphenolic Acetates in Mitigating
the Oxidative Stress and their Role in Angiogenesis. Curr Top Med Chem.
2017;17(9):1115. doi: 10.2174/156802661709170213214101. PubMed PMID: 28406076.

16: Ganguly G, Chakrabarti S, Chatterjee U, Saso L. Proteinopathy, oxidative
stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and
Parkinson's disease. Drug Des Devel Ther. 2017 Mar 16;11:797-810. doi:
10.2147/DDDT.S130514. eCollection 2017. Review. PubMed PMID: 28352155; PubMed
Central PMCID: PMC5358994.

17: Grewal GK, Kukal S, Kanojia N, Saso L, Kukreti S, Kukreti R. Effect of
Oxidative Stress on ABC Transporters: Contribution to Epilepsy
Pharmacoresistance. Molecules. 2017 Feb 27;22(3). pii: E365. doi:
10.3390/molecules22030365. Review. PubMed PMID: 28264441.

18: Shahraki O, Edraki N, Khoshneviszadeh M, Zargari F, Ranjbar S, Saso L, Firuzi
O, Miri R. Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in
vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular
dynamics simulation study. Drug Des Devel Ther. 2017 Feb 14;11:407-418. doi:
10.2147/DDDT.S119995. eCollection 2017. PubMed PMID: 28243063; PubMed Central
PMCID: PMC5317256.

19: Jouha J, Loubidi M, Bouali J, Hamri S, Hafid A, Suzenet F, Guillaumet G,
Dagcı T, Khouili M, Aydın F, Saso L, Armagan G. Synthesis of new heterocyclic
compounds based on pyrazolopyridine scaffold and evaluation of their
neuroprotective potential in MPP(+)-induced neurodegeneration. Eur J Med Chem.
2017 Mar 31;129:41-52. doi: 10.1016/j.ejmech.2017.02.019. Epub 2017 Feb 11.
PubMed PMID: 28214632.

20: Albert A, Tiwari V, Paul E, Ganesan D, Ayyavu M, Kujur R, Ponnusamy S,
Shanmugam K, Saso L, Govindan Sadasivam S. Expression of heterologous oxalate
decarboxylase in HEK293 cells confers protection against oxalate induced
oxidative stress as a therapeutic approach for calcium oxalate stone disease. J
Enzyme Inhib Med Chem. 2017 Dec;32(1):426-433. doi:
10.1080/14756366.2016.1256884. PubMed PMID: 28118755.

21: Suzen S, Gurer-Orhan H, Saso L. Detection of Reactive Oxygen and Nitrogen
Species by Electron Paramagnetic Resonance (EPR) Technique. Molecules. 2017 Jan
21;22(1). pii: E181. doi: 10.3390/molecules22010181. Review. PubMed PMID:
28117726.

22: Begic A, Djuric A, Ninkovic M, Stevanovic I, Djurdjevic D, Pavlovic M, Jelic
K, Pantelic A, Zebic G, Dejanovic B, Stanojevic I, Vojvodic D, Milosavljevic P,
Djukic M, Saso L. Disulfiram moderately restores impaired hepatic redox status of
rats subchronically exposed to cadmium. J Enzyme Inhib Med Chem. 2017
Dec;32(1):478-489. doi: 10.1080/14756366.2016.1261132. PubMed PMID: 28102089.

23: Angelova VT, Valcheva V, Vassilev NG, Buyukliev R, Momekov G, Dimitrov I,
Saso L, Djukic M, Shivachev B. Antimycobacterial activity of novel
hydrazide-hydrazone derivatives with 2H-chromene and coumarin scaffold. Bioorg
Med Chem Lett. 2017 Jan 15;27(2):223-227. doi: 10.1016/j.bmcl.2016.11.071. Epub
2016 Nov 25. PubMed PMID: 27914798.

24: Brizzolari A, Campisi GM, Santaniello E, Razzaghi-Asl N, Saso L, Foti MC.
Effect of organic co-solvents in the evaluation of the hydroxyl radical
scavenging activity by the 2-deoxyribose degradation assay: The paradigmatic case
of α-lipoic acid. Biophys Chem. 2017 Jan;220:1-6. doi: 10.1016/j.bpc.2016.10.005.
Epub 2016 Oct 31. PubMed PMID: 27825024.

25: Hosseini R, Moosavi F, Rajaian H, Silva T, Magalhães E Silva D, Soares P,
Saso L, Edraki N, Miri R, Borges F, Firuzi O. Discovery of neurotrophic agents
based on hydroxycinnamic acid scaffold. Chem Biol Drug Des. 2016
Dec;88(6):926-937. doi: 10.1111/cbdd.12829. Epub 2016 Sep 9. PubMed PMID:
27465784.

26: Jović M, Cerović S, Zolotarevska L, Gačević M, Stanojević I, Miller K, Đukić
M, Saso L, Jauković L, Vojvodić D. Correlation of local and systemic expression
of survivin with histopathological parameters of cutaneous melanoma. Vojnosanit
Pregl. 2016 Nov;73(11):1022-9. doi: 10.2298/VSP150519119J. PubMed PMID: 29328641.

27: Malhotra S, Tavakkoli M, Edraki N, Miri R, Sharma SK, Prasad AK, Saso L, Len
C, Parmar VS, Firuzi O. Neuroprotective and Antioxidant Activities of
4-Methylcoumarins: Development of Structure-Activity Relationships. Biol Pharm
Bull. 2016;39(9):1544-8. doi: 10.1248/bpb.b16-00005. PubMed PMID: 27582333.

28: Verbanac D, Malik R, Chand M, Kushwaha K, Vashist M, Matijašić M, Stepanić V,
Perić M, Paljetak HČ, Saso L, Jain SC. Synthesis and evaluation of antibacterial
and antioxidant activity of novel 2-phenyl-quinoline analogs derivatized at
position 4 with aromatically substituted 4H-1,2,4-triazoles. J Enzyme Inhib Med
Chem. 2016;31(sup2):104-110. Epub 2016 Jun 19. PubMed PMID: 27319400.

29: Phan CW, Sabaratnam V, Bovicelli P, Righi G, Saso L. Negletein as a
neuroprotectant enhances the action of nerve growth factor and induces neurite
outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42(6):591-599. doi:
10.1002/biof.1296. Epub 2016 May 19. PubMed PMID: 27193378.

30: Carvalho AN, Firuzi O, Gama MJ, Horssen JV, Saso L. Oxidative Stress and
Antioxidants in Neurological Diseases: Is There Still Hope? Curr Drug Targets.
2017 Mar 30;18(6):705-718. doi: 10.2174/1389450117666160401120514. PubMed PMID:
27033198.

31: Korkina L, Ozben T, Saso L. Modulation of Oxidative Stress: Pharmaceutical
and Pharmacological Aspects. Oxid Med Cell Longev. 2016;2016:6023417. doi:
10.1155/2016/6023417. Epub 2016 Feb 24. PubMed PMID: 27006747; PubMed Central
PMCID: PMC4783544.

32: Gurer-Orhan H, Karaaslan C, Ozcan S, Firuzi O, Tavakkoli M, Saso L, Suzen S.
Novel indole-based melatonin analogues: Evaluation of antioxidant activity and
protective effect against amyloid β-induced damage. Bioorg Med Chem. 2016 Apr
15;24(8):1658-64. doi: 10.1016/j.bmc.2016.02.039. Epub 2016 Mar 2. PubMed PMID:
26970662.

33: Cort A, Ozben T, Saso L, De Luca C, Korkina L. Redox Control of Multidrug
Resistance and Its Possible Modulation by Antioxidants. Oxid Med Cell Longev.
2016;2016:4251912. doi: 10.1155/2016/4251912. Epub 2016 Jan 5. Review. PubMed
PMID: 26881027; PubMed Central PMCID: PMC4736404.

34: Graziani M, Antonilli L, Togna AR, Grassi MC, Badiani A, Saso L.
Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of
Modulators of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:8408479. doi:
10.1155/2016/8408479. Epub 2015 Dec 28. Review. PubMed PMID: 26823954; PubMed
Central PMCID: PMC4707355.

35: Moosavi F, Hosseini R, Saso L, Firuzi O. Modulation of neurotrophic signaling
pathways by polyphenols. Drug Des Devel Ther. 2015 Dec 21;10:23-42. doi:
10.2147/DDDT.S96936. eCollection 2016. Review. PubMed PMID: 26730179; PubMed
Central PMCID: PMC4694682.

36: Filipský T, Mladenka P, Macáková K, Hrdina R, Saso L, Marchetti F, Pettinari
C. Effect of novel 1-phenyl-3-methyl-4-acylpyrazolones on iron chelation and
Fenton reaction. Free Radic Biol Med. 2014 Oct;75 Suppl 1:S29-30. doi:
10.1016/j.freeradbiomed.2014.10.758. Epub 2014 Dec 10. PubMed PMID: 26461329.

37: Khoshaman K, Yousefi R, Tamaddon AM, Saso L, Moosavi-Movahedi AA. The impact
of Hydrogen peroxide on structure, stability and functional properties of Human
R12C mutant αA-crystallin: The imperative insights into pathomechanism of the
associated congenital cataract incidence. Free Radic Biol Med. 2015
Dec;89:819-30. doi: 10.1016/j.freeradbiomed.2015.09.013. Epub 2015 Oct 12. PubMed
PMID: 26459035.

38: Djuric A, Begic A, Gobeljic B, Stanojevic I, Ninkovic M, Vojvodic D, Pantelic
A, Zebic G, Prokic V, Dejanovic B, Stojanovic I, Pavlica M, Djukic D, Saso L,
Djurdjevic D, Pavlovic M, Topic A, Vujanovic D, Stevnovic I, Djukic M. Oxidative
stress, bioelements and androgen status in testes of rats subacutely exposed to
cadmium. Food Chem Toxicol. 2015 Dec;86:25-33. doi: 10.1016/j.fct.2015.09.004.
Epub 2015 Sep 16. PubMed PMID: 26385724.

39: Martin J, Mladěnka P, Saso L, Kostova I. Lanthanide(III) complexes are more
active inhibitors of the Fenton reaction than pure ligands. Redox Rep. 2016
Mar;21(2):84-9. doi: 10.1179/1351000215Y.0000000031. Epub 2016 Feb 18. PubMed
PMID: 26193444.

40: Miri R, Nejati M, Saso L, Khakdan F, Parshad B, Mathur D, Parmar VS, Bracke
ME, Prasad AK, Sharma SK, Firuzi O. Structure-activity relationship studies of
4-methylcoumarin derivatives as anticancer agents. Pharm Biol. 2016;54(1):105-10.
doi: 10.3109/13880209.2015.1016183. Epub 2015 May 27. PubMed PMID: 26017566.

41: Miller E, Morel A, Saso L, Saluk J. Melatonin redox activity. Its potential
clinical applications in neurodegenerative disorders. Curr Top Med Chem.
2015;15(2):163-9. Review. PubMed PMID: 25985818.

42: Borges F, Garrido J, Saso L, Suzen S. Oxidative stress as a pharmacological
target for medicinal chemistry: synthesis and evaluation of compounds with redox
activity - part 4. Curr Top Med Chem. 2015;15(9):821. PubMed PMID: 25821976.

43: Borges F, Garrido J, Saso L, Suzen S. Oxidative stress as a pharmacological
target for medicinal chemistry: synthesis and evaluation of compounds with redox
activity--part 3. Curr Top Med Chem. 2015;15(5):414. PubMed PMID: 25714430.

44: Ramprasath T, Vasudevan V, Sasikumar S, Puhari SS, Saso L, Selvam GS.
Regression of oxidative stress by targeting eNOS and Nrf2/ARE signaling: a guided
drug target for cardiovascular diseases. Curr Top Med Chem. 2015;15(9):857-71.
Review. PubMed PMID: 25697563.

45: Ivanovska N, Saso L, Dimitrov P. Kinase inhibitors with redox and
anti-inflammatory activities. Curr Top Med Chem. 2015;15(9):872-85. Review.
PubMed PMID: 25697562.

46: Das KK, Razzaghi-Asl N, Tikare SN, Di Santo R, Costi R, Messore A, Pescatori
L, Crucitti GC, Jargar JG, Dhundasi SA, Saso L. Hypoglycemic activity of curcumin
synthetic analogues in alloxan-induced diabetic rats. J Enzyme Inhib Med Chem.
2016;31(1):99-105. doi: 10.3109/14756366.2015.1004061. Epub 2015 Feb 16. PubMed
PMID: 25683079.

47: Borges F, Garrido J, Saso L, Suzen S. Oxidative stress as a pharmacological
target for medicinal chemistry: synthesis and evaluation of compounds with redox
activity - part 2. Curr Top Med Chem. 2015;15(2):84. PubMed PMID: 25599751.

48: Joshi R, Rohil V, Arora S, Kumar A, Manral S, Goel S, Priya N, Singh P,
Ponnan P, Chatterji S, Dwarakanath BS, Saluja D, Rawat DS, Prasad AK, Saso L,
Kohli E, DePass AL, Bracke ME, Parmar VS, Raj HG. The Competence of
7,8-Diacetoxy-4-Methylcoumarin and Other Polyphenolic Acetates in Mitigating the
Oxidative Stress and their Role in Angiogenesis. Curr Top Med Chem.
2015;15(2):179-86. Review. Erratum in: Curr Top Med Chem. 2017;17 (9):1115.
PubMed PMID: 25547104.

49: Miller E, Morel A, Saso L, Saluk J. Melatonin Redox Activity. Its Potential
Clinical Application in Neurodegenerative Disorders. Curr Top Med Chem. 2014 Dec
29. [Epub ahead of print] PubMed PMID: 25547102.

50: Borges F, Saso L, Garrido J, Suzen S. Oxidative stress as a pharmacological
target for medicinal chemistry: synthesis and evaluation of compounds with redox
activity - part 1. Curr Top Med Chem. 2014;14(22):2461. PubMed PMID: 25515767.

51: Joshi R, Arora S, Kumar A, Manral S, Rohil V, Goel S, Priya N, Singh P,
Ponnan P, Chatterji S, Dwarakanath BS, Saluja D, Rawat DS, Prasad AK, Saso L,
Kohli E, DePass AL, Bracke ME, Parmar VS, Raj HG. The Competence Of
7,8-Diacetoxy-4-Methylcoumarinand Other Polyphenolic Acetates In Mitigating The
Oxidative Stress And Their Role In Angiogenesis. Curr Top Med Chem. 2014 Dec 9.
[Epub ahead of print] PubMed PMID: 25496273.

52: Venkateswaran K, Verma A, Bhatt AN, Agrawala PK, Raj HG, Malhotra S, Prasad
AK, Wever OD, Bracke ME, Saso L, Parmar VS, Shrivastava A, Dwarakanath BS.
Modifications of cell signalling and redox balance by targeting protein
acetylation using natural and engineered molecules: implications in cancer
therapy. Curr Top Med Chem. 2014;14(22):2495-507. Review. PubMed PMID: 25478886.

53: Valcheva-Traykova M, Saso L, Kostova I. Involvement of lanthanides in the
free radicals homeostasis. Curr Top Med Chem. 2014;14(22):2508-19. Review. PubMed
PMID: 25478885.

54: Muronetz V, Asryants R, Semenyuk P, Schmalhausen E, Saso L. Hydrophobic plant
antioxidants. Preparation of nanoparticles and their application for prevention
of neurodegenerative diseases. Review and experimental data. Curr Top Med Chem.
2014;14(22):2520-8. Review. PubMed PMID: 25478884.

55: Profumo E, Buttari B, Saso L, Rigano R. Pleiotropic effects of statins in
atherosclerotic disease: focus on the antioxidant activity of atorvastatin. Curr
Top Med Chem. 2014;14(22):2542-51. Review. PubMed PMID: 25478882.

56: Shekari F, Sadeghpour H, Javidnia K, Saso L, Nazari F, Firuzi O, Miri R.
Cytotoxic and multidrug resistance reversal activities of novel
1,4-dihydropyridines against human cancer cells. Eur J Pharmacol. 2015 Jan
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57: Saso L, Firuzi O. Pharmacological applications of antioxidants: lights and
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58: Chandak N, Bhardwaj JK, Zheleva-Dimitrova D, Kitanov G, Sharma RK, Sharma PK,
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59: Banerjee P, Sahoo A, Anand S, Ganguly A, Righi G, Bovicelli P, Saso L,
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60: Tavakkoli M, Miri R, Jassbi AR, Erfani N, Asadollahi M, Ghasemi M, Saso L,
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61: Buttari B, Profumo E, Segoni L, D'Arcangelo D, Rossi S, Facchiano F, Saso L,
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62: Miller E, Morel A, Saso L, Saluk J. Isoprostanes and neuroprostanes as
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63: Ponnan P, Kumar A, Singh P, Gupta P, Joshi R, Gaspari M, Saso L, Prasad AK,
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64: Togna AR, Firuzi O, Latina V, Parmar VS, Prasad AK, Salemme A, Togna GI, Saso
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65: Borges F, Saso L, Garrido J, Suzen S. Synthesis, evaluation and
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66: Borges F, Saso L, Garrido J, Suzen S. Synthesis, evaluation and
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67: Buttari B, Profumo E, Facchiano F, Ozturk EI, Segoni L, Saso L, Riganò R.
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68: Kostova I, Saso L. Advances in research of Schiff-base metal complexes as
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69: Buttari B, Profumo E, Businaro R, Saso L, Capoano R, Salvati B, Riganò R.
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70: Tsvetkova D, Obreshkova D, Zheleva-Dimitrova D, Saso L. Antioxidant activity
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71: Firuzi O, Javidnia K, Mansourabadi E, Saso L, Mehdipour AR, Miri R. Reversal
of multidrug resistance in cancer cells by novel asymmetrical
1,4-dihydropyridines. Arch Pharm Res. 2013 Nov;36(11):1392-402. doi:
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72: Lombardo E, Sabellico C, Hájek J, Staňková V, Filipský T, Balducci V, De Vito
P, Leone S, Bavavea EI, Silvestri IP, Righi G, Luly P, Saso L, Bovicelli P,
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73: Suzen S, Saso L. Editorial: antioxidant heterocyclic compounds in drug
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74: Profumo E, Buttari B, Saso L, Capoano R, Salvati B, Riganò R. T lymphocyte
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75: Kumar A, Ponnan P, Raj HG, Parmar VS, Saso L. Comparative specificities of
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4-methylcoumarins and their inhibitory effect on AFB1-induced genotoxicity in
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76: Macáková K, Řeháková Z, Mladěnka P, Karlíčková J, Filipský T, Říha M, Prasad
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77: Macáková K, Mladěnka P, Filipský T, Říha M, Jahodář L, Trejtnar F, Bovicelli
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78: Verbanac D, Jain SC, Jain N, Chand M, Cipčić Paljetak H, Matijašić M, Perić
M, Stepanić V, Saso L. An efficient and convenient microwave-assisted chemical
synthesis of (thio)xanthones with additional in vitro and in silico
characterization. Bioorg Med Chem. 2012 May 15;20(10):3180-5. doi:
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79: Profumo E, Di Franco M, Buttari B, Masella R, Filesi C, Tosti ME, Scrivo R,
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80: Garrido J, Gaspar A, Garrido EM, Miri R, Tavakkoli M, Pourali S, Saso L,
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antioxidant activity and lipophilicity protect PC12 cells against oxidative
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81: Filipský T, Mladěnka P, Macáková K, Hrdina R, Saso L, Marchetti F, Pettinari
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82: Adriani W, Travaglini D, Lacivita E, Saso L, Leopoldo M, Laviola G.
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motivation and circadian rhythm profiles in mice. Neuropharmacology. 2012
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83: Kancheva VD, Saso L, Angelova SE, Foti MC, Slavova-Kasakova A, Daquino C,
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84: Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant therapy: current status
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85: Kostova I, Bhatia S, Grigorov P, Balkansky S, Parmar VS, Prasad AK, Saso L.
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86: Barzegar A, Pedersen JZ, Incerpi S, Moosavi-Movahedi AA, Saso L. The
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87: Trapani L, Segatto M, Simeoni V, Balducci V, Dhawan A, Parmar VS, Prasad AK,
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88: Manral S, Bhatia S, Sinha R, Kumar A, Rohil V, Arya A, Dhawan A, Arya P,
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Vijayan VK, Saso L, Parmar VS, DePass AL, Prasad AK, Raj HG. Normalization of
deranged signal transduction in lymphocytes of COPD patients by the novel calcium
channel blocker H-DHPM. Biochimie. 2011 Jul;93(7):1146-56. doi:
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89: Buttari B, Profumo E, Capozzi A, Facchiano F, Saso L, Sorice M, Riganò R.
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90: Mladěnka P, Macáková K, Filipský T, Zatloukalová L, Jahodář L, Bovicelli P,
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91: Singh P, Ponnan P, Priya N, Tyagi TK, Gaspari M, Krishnan S, Cuda G, Joshi P,
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92: Gaspar A, Martins M, Silva P, Garrido EM, Garrido J, Firuzi O, Miri R, Saso
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93: Kaushik R, Marwah RG, Gupta P, Saran S, Saso L, Parmar VS, Saxena RK.
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94: Le-Thi-Thu H, Casañola-Martín GM, Marrero-Ponce Y, Rescigno A, Saso L, Parmar
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95: Petrucci R, Saso L, Kumar V, Prasad AK, Malhotra SV, Parmar VS, Marrosu G. A
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7,8-dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic
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96: Kancheva VD, Saso L, Boranova PV, Khan A, Saroj MK, Pandey MK, Malhotra S,
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97: Gupta P, Balwani S, Kumar S, Aggarwal N, Rossi M, Paumier S, Caruso F,
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among other secondary metabolites of Piper galeatum shows inhibition of
TNFalpha-induced cell adhesion molecule expression on human endothelial cells.
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98: Natella F, Lorrain B, Prasad AK, Parmar VS, Saso L, Scaccini C.
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of human low-density lipoprotein oxidation. Biochimie. 2010 Sep;92(9):1147-52.
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99: Morabito G, Trombetta D, Singh Brajendra K, Prasad Ashok K, Parmar Virinder
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100: Mladenka P, Macáková K, Zatloukalová L, Reháková Z, Singh BK, Prasad AK,
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101: Singh P, Ponnan P, Krishnan S, Tyagi TK, Priya N, Bansal S, Scumaci D,
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102: Koot S, Adriani W, Saso L, van den Bos R, Laviola G. Home cage testing of
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103: Macrì S, Granstrem O, Shumilina M, Antunes Gomes dos Santos FJ, Berry A,
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neonatal stressors in mice. Horm Behav. 2009 Oct;56(4):391-8. doi:
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104: Dimitrova P, Gyurkovska V, Shalova I, Saso L, Ivanovska N. Inhibition of
zymosan-induced kidney dysfunction by tyrphostin AG-490. J Inflamm (Lond). 2009
May 5;6:13. doi: 10.1186/1476-9255-6-13. PubMed PMID: 19416544; PubMed Central
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105: Manconia M, Pendás J, Ledón N, Moreira T, Sinico C, Saso L, Fadda AM.
Phycocyanin liposomes for topical anti-inflammatory activity: in-vitro in-vivo
studies. J Pharm Pharmacol. 2009 Apr;61(4):423-30. doi: 10.1211/jpp/61.04.0002.
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106: Arora S, Tyagi YK, Kumar A, Majumder S, Saluja D, Raj HG, Chatterjee S, Saso
L, Prasad AK, Parmar VS. The role of calreticulin transacetylase in the
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107: Bansal S, Ponnan P, Raj HG, Weintraub ST, Chopra M, Kumari R, Saluja D,
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Autoacetylation of purified calreticulin transacetylase utilizing acetoxycoumarin
as the acetyl group donor. Appl Biochem Biotechnol. 2009 May;157(2):285-98. doi:
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108: Naletova I, Schmalhausen E, Kharitonov A, Katrukha A, Saso L, Caprioli A,
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intrinsic component of amyloid structures. Biochim Biophys Acta. 2008
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109: Yordanov M, Dimitrova P, Patkar S, Saso L, Ivanovska N. Inhibition of
Candida albicans extracellular enzyme activity by selected natural substances and
their application in Candida infection. Can J Microbiol. 2008 Jun;54(6):435-40.
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110: Firuzi O, Spadaro A, Spadaro C, Riccieri V, Petrucci R, Marrosu G, Saso L.
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111: Arora S, Vohra P, Kumar A, Tyagi YK, Raj HG, Dawarkanath BS, Saluja D, Saso
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112: Rehakova Z, Koleckar V, Cervenka F, Jahodar L, Saso L, Opletal L, Jun D,
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and Their Synthesized Analogs Measured by the SIA Method. Toxicol Mech Methods.
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113: Pedersen JZ, Oliveira C, Incerpi S, Kumar V, Fiore AM, De Vito P, Prasad AK,
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114: Jones DS, Saso L. Chemistry and biology of antioxidants. J Pharm Pharmacol.
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115: Riccieri V, Spadaro A, Fuksa L, Firuzi O, Saso L, Valesini G. Specific
oxidative stress parameters differently correlate with nailfold capillaroscopy
changes and organ involvement in systemic sclerosis. Clin Rheumatol. 2008
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116: Ognibene E, Bovicelli P, Adriani W, Saso L, Laviola G. Behavioral effects of
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117: Croce A, Firuzi O, Altieri F, Eufemi M, Agostino R, Priori R, Bombardieri M,
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IgG of patients with rheumatoid arthritis. J Clin Lab Anal. 2007;21(5):303-14.
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118: Villo L, Danilas K, Metsala A, Kreen M, Vallikivi I, Vija S, Pehk T, Saso L,
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approach affording deoxy sugar derivatives also in the form of aldehyde. J Org
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119: Shalova IN, Naletova IN, Saso L, Muronetz VI, Izumrudov VA. Interaction of
polyelectrolytes with proteins, 3. Influence of complexing polycations on the
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120: Schmalhausen EV, Zhlobek EB, Shalova IN, Firuzi O, Saso L, Muronetz VI.
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dehydrogenase. Food Chem Toxicol. 2007 Oct;45(10):1988-93. Epub 2007 May 3.
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121: Artico M, Bronzetti E, Saso L, Felici LM, D'Ambrosio A, Forte F, Grande C,
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neurotrophins in the seminiferous tubules of rats treated by lonidamine. Eur J
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122: Shalova IN, Cechalova K, Rehakova Z, Dimitrova P, Ognibene E, Caprioli A,
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cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of
Alzheimer's disease. Biochim Biophys Acta. 2007 May;1770(5):826-32. Epub 2007 Feb
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123: Ruiz C, Falcocchio S, Pastor FI, Saso L, Diaz P. Helicobacter pylori EstV:
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an epsilon-proteobacterium. Appl Environ Microbiol. 2007 Apr;73(8):2423-31. Epub
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124: Khanova HA, Markossian KA, Kleimenov SY, Levitsky DI, Chebotareva NA, Golub
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125: Markossian KA, Khanova HA, Kleimenov SY, Levitsky DI, Chebotareva NA,
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126: Firuzi O, Mladenka P, Riccieri V, Spadaro A, Petrucci R, Marrosu G, Saso L.
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127: Firuzi O, Fuksa L, Spadaro C, Bousová I, Riccieri V, Spadaro A, Petrucci R,
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128: Falcocchio S, Ruiz C, Pastor FI, Saso L, Diaz P. Identification of a
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129: Shalova IN, Asryants RA, Sholukh MV, Saso L, Kurganov BI, Muronetz VI,
Izumrudov VA. Interaction of polyanions with basic proteins, 2(a) : influence of
complexing polyanions on the thermo-aggregation of oligomeric enzymes. Macromol
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130: Maranghi F, Mantovani A, Macrì C, Romeo A, Eleuteri P, Leter G, Rescia M,
Spanò M, Saso L. Long-term effects of lonidamine on mouse testes. Contraception.
2005 Oct;72(4):268-72. PubMed PMID: 16181970.

131: Traina ME, Guarino M, Urbani E, Saso L, Eleuteri P, Cordelli E, Rescia M,
Leter G, Spanò M. Lonidamine transiently affects spermatogenesis in pubertal CD1
mice. Contraception. 2005 Oct;72(4):262-7. PubMed PMID: 16181969.

132: Yordanov M, Dimitrova P, Patkar S, Falcocchio S, Xoxi E, Saso L, Ivanovska
N. Ibogaine reduces organ colonization in murine systemic and gastrointestinal
Candida albicans infections. J Med Microbiol. 2005 Jul;54(Pt 7):647-53. PubMed
PMID: 15947429.

133: Daniele C, Dahamna S, Firuzi O, Sekfali N, Saso L, Mazzanti G. Atractylis
gummifera L. poisoning: an ethnopharmacological review. J Ethnopharmacol. 2005
Feb 28;97(2):175-81. Epub 2005 Jan 13. Review. PubMed PMID: 15707749.

134: Firuzi O, Lacanna A, Petrucci R, Marrosu G, Saso L. Evaluation of the
antioxidant activity of flavonoids by "ferric reducing antioxidant power" assay
and cyclic voltammetry. Biochim Biophys Acta. 2005 Jan 18;1721(1-3):174-84. Epub
2004 Dec 22. PubMed PMID: 15652192.

135: Firuzi O, Mladenka P, Petrucci R, Marrosu G, Saso L. Hypochlorite scavenging
activity of flavonoids. J Pharm Pharmacol. 2004 Jun;56(6):801-7. PubMed PMID:
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136: Ruiz C, Falcocchio S, Xoxi E, Pastor FI, Diaz P, Saso L. Activation and
inhibition of Candida rugosa and Bacillus-related lipases by saturated fatty
acids, evaluated by a new colorimetric microassay. Biochim Biophys Acta. 2004 Jun
11;1672(3):184-91. PubMed PMID: 15182938.

137: Firuzi O, Giansanti L, Vento R, Seibert C, Petrucci R, Marrosu G, Agostino
R, Saso L. Hypochlorite scavenging activity of hydroxycinnamic acids evaluated by
a rapid microplate method based on the measurement of chloramines. J Pharm
Pharmacol. 2003 Jul;55(7):1021-7. PubMed PMID: 12906760.

138: Grippa E, Gatto MT, Caiola M, Persio D, Tita B, Saso L. Effect of lonidamine
on alpha2-macroglobulin, hemopexin and alpha1-antitrypsin in the rat testis and
epididymis. Res Commun Mol Pathol Pharmacol. 2001;110(3-4):169-82. PubMed PMID:
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139: Bonanni G, Saso L. [Evaluation of the adherence to the asthma guidelines by
the administration of a questionnaire in community pharmacies]. Minerva Med. 2003
Feb;94(1):29-40. Italian. PubMed PMID: 12719700.

140: Saso L. [Effects of drug abuse on sexual response]. Ann Ist Super Sanita.
2002;38(3):289-96. Review. Italian. PubMed PMID: 12645180.

141: Gatto MT, Firuzi O, Agostino R, Grippa E, Borsò A, Spinelli F, Pavan L,
Petrolati M, Petrucci R, Marrosu G, Saso L. Development of a new assay for the
screening of hypochlorous acid scavengers based on reversed-phase
high-performance liquid chromatography. Biomed Chromatogr. 2002 Sep;16(6):404-11.
PubMed PMID: 12228898.

142: Leone MG, Abdel HH, Gennaro G, Amici S, Conte D, Romanelli F, Latini M,
Isidori A, Saso L, Silvestrini B. Changes of lipocalin type prostaglandin
D-synthase in the seminal plasma of subfertile man. Res Commun Mol Pathol
Pharmacol. 2001 Jul-Aug;110(1-2):17-25. PubMed PMID: 12090353.

143: Bolle P, Evandri MG, Saso L. The controversial efficacy of vitamin E for
human male infertility. Contraception. 2002 Apr;65(4):313-5. Review. PubMed PMID:
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144: Leone MG, Haq HA, Saso L. Lipocalin type prostaglandin D-synthase: which
role in male fertility? Contraception. 2002 Apr;65(4):293-5. Review. PubMed PMID:
12020781.

145: Gatto MT, Tita B, Artico M, Saso L. Recent studies on lonidamine, the lead
compound of the antispermatogenic indazol-carboxylic acids. Contraception. 2002
Apr;65(4):277-8. Review. PubMed PMID: 12020777.

146: Cheng CY, Mo My, Grima J, Saso L, Tita B, Mruk D, Silvestrini B. Indazole
carboxylic acids in male contraception. Contraception. 2002 Apr;65(4):265-8.
Review. PubMed PMID: 12020774.

147: Gatto MT, Falcocchio S, Grippa E, Mazzanti G, Battinelli L, Nicolosi G,
Lambusta D, Saso L. Antimicrobial and anti-lipase activity of quercetin and its
C2-C16 3-O-acyl-esters. Bioorg Med Chem. 2002 Feb;10(2):269-72. PubMed PMID:
11741775.

148: Tita B, Leone MG, Casini ML, Corubolo C, Bordi F, Guidolin D, Fumagalli E,
Romanelli L, Mattioli F, Fehér J, Saso L. Corneal toxicity of xylazine and
clonidine, in combination with ketamine, in the rat. Ophthalmic Res. 2001
Nov-Dec;33(6):345-52. PubMed PMID: 11721188.

149: Vitalone A, Bordi F, Baldazzi C, Mazzanti G, Saso L, Tita B.
Anti-proliferative effect on a prostatic epithelial cell line (PZ-HPV-7) by
Epilobium angustifolium L. Farmaco. 2001 May-Jul;56(5-7):483-9. PubMed PMID:
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150: Tita B, Abdel-Haq H, Vitalone A, Mazzanti G, Saso L. Analgesic properties of
Epilobium angustifolium, evaluated by the hot plate test and the writhing test.
Farmaco. 2001 May-Jul;56(5-7):341-3. PubMed PMID: 11482754.

151: Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, Saso L, Leone
MG, Palmery M, Mruk D. Two new male contraceptives exert their effects by
depleting germ cells prematurely from the testis. Biol Reprod. 2001
Aug;65(2):449-61. PubMed PMID: 11466213.

152: Befani O, Grippa E, Saso L, Turini P, Mondovì B. Inhibition of monoamine
oxidase by metronidazole. Inflamm Res. 2001 Apr;50 Suppl 2:S136-7. PubMed PMID:
11411591.

153: Saso L, Valentini G, Casini ML, Grippa E, Gatto MT, Leone MG, Silvestrini B.
Inhibition of heat-induced denaturation of albumin by nonsteroidal
antiinflammatory drugs (NSAIDs): pharmacological implications. Arch Pharm Res.
2001 Apr;24(2):150-8. PubMed PMID: 11339635.

154: Saso L, Grippa E, Gatto MT, Silvestrini B. Inhibition of calcium oxalate
precipitation by bile salts. Int J Urol. 2001 Mar;8(3):124-7. PubMed PMID:
11260337.

155: Riccieri V, Spadaro A, Saso L, Valentini G, Taccari E, Silvestrini B.
Immunohistologic markers of immune activation and changes of glycosylation of
serum proteins in primary Sjögren's syndrome. Clin Exp Rheumatol. 2001
Jan-Feb;19(1):53-8. PubMed PMID: 11247326.

156: Saso L, Silvestrini B. [Ethical issues of human experimentation with special
reference to informed consent]. Minerva Med. 2000 Oct;91(10):255-65. Italian.
PubMed PMID: 11236391.

157: Grippa E, Gatto MT, Leone MG, Tita B, Adbel-Haq H, Vitalone A, Silvestrini
B, Saso L. Analysis of lonidamine in rat serum and testis by high performance
liquid chromatography. Biomed Chromatogr. 2001 Feb;15(1):1-8. PubMed PMID:
11180293.

158: Saso L, Silvestrini B. Antidenaturant drugs for cataract and other
condensation diseases. Med Hypotheses. 2001 Jan;56(1):114-20. PubMed PMID:
11133267.

159: Abdel-Haq H, Cometa MF, Palmery M, Leone MG, Silvestrini B, Saso L. Relaxant
effects of Hydrastis canadensis L. and its major alkaloids on guinea pig isolated
trachea. Pharmacol Toxicol. 2000 Nov;87(5):218-22. PubMed PMID: 11129501.

160: Grippa E, Pavone F, Gatto MT, Petrucci R, Marrosu G, Silvestrini B, Saso L.
In vitro evaluation of antioxidant activity by electrophoresis and high
performance liquid chromatography. Biochim Biophys Acta. 2000 Dec
15;1524(2-3):171-7. PubMed PMID: 11113564.

161: Saso L, Tommasino P, Italiano G, Grippa E, Leone MG, Gatto MT, Silvestrini
B. Changes of acute-phase proteins in streptozotocin-induced diabetic rats.
Physiol Res. 2000;49(4):403-9. PubMed PMID: 11072799.

162: Saso L, Silvestrini B. [Nephrolithiasis]. Recenti Prog Med. 2000
Jul-Aug;91(7-8):388-95. Review. Italian. PubMed PMID: 10932926.

163: Mazzanti G, Mascellino MT, Battinelli L, Coluccia D, Manganaro M, Saso L.
Antimicrobial investigation of semipurified fractions of Ginkgo biloba leaves. J
Ethnopharmacol. 2000 Jul;71(1-2):83-8. PubMed PMID: 10904149.

164: Leone MG, Grippa E, Guidolin D, Tita B, Abdel-Haq H, Gatto MT, Bordi F,
Cheng CY, Silvestrini B, Saso L. Effects of lonidamine on testicular and
epididymal proteins in the rat. Reprod Toxicol. 2000 May-Jun;14(3):257-63. PubMed
PMID: 10838127.

165: Abdel-Haq H, Giacomelli S, Palmery M, Leone MG, Saso L, Silvestrini B.
Aflatoxins inhibit prolactin secretion by rat pituitary cells in culture. Drug
Chem Toxicol. 2000 May;23(2):381-6. PubMed PMID: 10826104.

166: Abdel-Haq H, Palmery M, Leone MG, Saso L, Silvestrini B. Stimulation of
guinea pig isolated atria by aflatoxins. Toxicol In Vitro. 2000 Jun;14(3):193-7.
PubMed PMID: 10806369.

167: Abdel-Haq H, Palmery M, Leone MG, Saso L, Silvestrini B. Relaxant effects of
aflatoxins on isolated guinea pig trachea. Toxicol Sci. 2000 May;55(1):162-70.
PubMed PMID: 10788571.

168: Grippa E, Santini L, Castellano G, Gatto MT, Leone MG, Saso L. Simultaneous
determination of hydrocortisone, dexamethasone, indomethacin, phenylbutazone and
oxyphenbutazone in equine serum by high-performance liquid chromatography. J
Chromatogr B Biomed Sci Appl. 2000 Jan 28;738(1):17-25. PubMed PMID: 10778922.

169: Saso L, Bonanni G, Grippa E, Gatto MT, Leone MG, Silvestrini B. Interaction
of hyaluronic acid with mucin, evaluated by gel permeation chromatography. Res
Commun Mol Pathol Pharmacol. 1999;104(3):277-84. PubMed PMID: 10741378.

170: Saso L, Grippa E, Gatto MT, Leone MG, Silvestrini B. Inhibition of
heat-induced aggregation of beta- and gamma-crystallin by alpha-crystallin
evaluated by gel permeation HPLC. Biochemistry (Mosc). 2000 Feb;65(2):208-12.
PubMed PMID: 10713549.

171: Saso L, Valentini G, Riccieri V, Spadaro A, Zoppini A, Silvestrini B.
Changes of glycosylation of serum proteins in Sjögren's syndrome: correlation
with interleukin-6 and soluble interleukin-2 receptor. IUBMB Life. 1999
Oct;48(4):385-90. PubMed PMID: 10632566.

172: Grippa E, Valla R, Battinelli L, Mazzanti G, Saso L, Silvestrini B.
Inhibition of Candida rugosa lipase by berberine and structurally related
alkaloids, evaluated by high-performance liquid chromatography. Biosci Biotechnol
Biochem. 1999 Sep;63(9):1557-62. PubMed PMID: 10540743.

173: Saso L, Valentini G, Mattei E, Panzironi C, Casini ML, Grippa E, Silvestrini
B. Stabilization of rat serum proteins following oral administration of fish oil.
Arch Pharm Res. 1999 Oct;22(5):485-90. PubMed PMID: 10549576.

174: Leone MG, Saso L, Cheng CY, Silvestrini B. Micropurification of beta- and
gamma-crystallins from rabbit aqueous humor. Int J Biol Macromol. 1999
Nov;26(2-3):167-71. PubMed PMID: 10517525.

175: Cazzolla N, Saso L, Grima J, Leone MG, Grippa E, Cheng CY, Silvestrini B.
Development of an enzyme-linked immunosorbent assay, using a monoclonal antibody
against alpha2-macroglobulin, for the diagnosis of systemic lupus erythematosus.
Clin Biochem. 1999 Jun;32(4):249-55. PubMed PMID: 10463816.

176: Saso L, Tommasino P, Grippa E, Leone MG, Silvestrini B. Micromethods for the
analysis of tear proteins in pharmacological studies. Res Commun Mol Pathol
Pharmacol. 1999 Feb;103(2):149-65. PubMed PMID: 10461682.

177: Saso L, Leone MG, Mo MY, Grippa E, Cheng CY, Silvestrini B. Differential
changes in alpha2-macroglobulin and hemopexin in brain and liver in response to
acute inflammation. Biochemistry (Mosc). 1999 Jul;64(7):839-44. PubMed PMID:
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178: Saso L, Valentini G, Leone MG, Grippa E, Guglielmi R, Paris L, Cantore G,
Silvestrini B. Changes in concanavalin A-reactive proteins in neurological
disorders. J Clin Lab Anal. 1999;13(4):158-65. PubMed PMID: 10414595.

179: Saso L, Valentini G, Leone MG, Grippa E, Silvestrini B. Development of an in
vitro assay for the screening of substances capable of dissolving calcium oxalate
crystals. Urol Int. 1998;61(4):210-4. PubMed PMID: 10364751.

180: Saso L, Valentini G, Casini ML, Mattei E, Braghiroli L, Mazzanti G,
Panzironi C, Grippa E, Silvestrini B. Inhibition of protein denaturation by fatty
acids, bile salts and other natural substances: a new hypothesis for the
mechanism of action of fish oil in rheumatic diseases. Jpn J Pharmacol. 1999
Jan;79(1):89-99. PubMed PMID: 10082322.

181: Saso L, Valentini G, Grippa E, Leone MG, Silvestrini B. Effect of selected
substances on heat-induced aggregation of albumin, IgG and lysozyme. Res Commun
Mol Pathol Pharmacol. 1998 Oct;102(1):15-28. PubMed PMID: 9920343.

182: Saso L, Valentini G, Giardino AM, Spadaro A, Riccieri V, Zoppini A,
Silvestrini B. Changes of glycosylation of serum proteins in psoriatic arthritis,
studied by enzyme-linked lectin assay (ELLA), using concanavalin A. Biochem Mol
Biol Int. 1998 Dec;46(5):867-75. PubMed PMID: 9861440.

183: Saso L, Leone MG, Sorrentino C, Giacomelli S, Silvestrini B, Grima J, Li JC,
Samy E, Mruk D, Cheng CY. Quantification of prostaglandin D synthetase in
cerebrospinal fluid: a potential marker for brain tumor. Biochem Mol Biol Int.
1998 Nov;46(4):643-56. PubMed PMID: 9844724.

184: Saso L, Casini ML, Valentini G, Mattei E, Panzironi C, Silvestrini B.
Development of an HPLC assay to study the effect of endogenous and exogenous
substances on heat-induced aggregation of human serum albumin. Clin Chem Lab Med.
1998 Mar;36(3):155-62. PubMed PMID: 9589803.

185: Saso L, Valentini G, Casini ML, Mattei E, Panzironi C, Silvestrini B.
Development of a turbidimetric assay to study the effect of urinary components on
calcium oxalate precipitation. Urol Int. 1998;60(1):47-52. PubMed PMID: 9519421.

186: Li AH, Zwain IH, Pineau C, Cazzolla N, Saso L, Silvestrini B, Bardin CW,
Cheng CY. Response of alpha 2-macroglobulin messenger ribonucleic acid expression
to acute inflammation in the testis is different from the response in the liver
and brain. Biol Reprod. 1994 Jun;50(6):1287-96. PubMed PMID: 7521677.

187: Leone MG, Saso L, Del Vecchio A, Mo MY, Silvestrini B, Cheng CY.
Micropurification of two human cerebrospinal fluid proteins by high performance
electrophoresis chromatography. J Neurochem. 1993 Aug;61(2):533-40. PubMed PMID:
8336140.

188: Saso L, Silvestrini B, Cheng CY. The use of high-performance electrophoresis
chromatography for the micropurification of cerebrospinal fluid proteins in the
rat. Anal Biochem. 1993 Aug 1;212(2):315-24. PubMed PMID: 8214572.

189: Saso L, Silvestrini B, Guglielmotti A, Lahita R, Cheng CY. Abnormal
glycosylation of alpha 2-macroglobulin, a non-acute-phase protein in patients
with autoimmune diseases. Inflammation. 1993 Aug;17(4):465-79. PubMed PMID:
7691738.

190: Saso L, Silvestrini B, Lahita R, Cheng CY. Changes of immunoreactivity in
alpha 1-antitrypsin in patients with autoimmune diseases. Inflammation. 1993
Jun;17(3):383-400. PubMed PMID: 7687239.

191: Guglielmotti A, Silvestrini B, Saso L, Zwain I, Cheng CY. Chronic
inflammatory response in the rat can be blocked by bindarit. Biochem Mol Biol
Int. 1993 Mar;29(4):747-56. PubMed PMID: 7683947.

192: Zwain IH, Grima J, Stahler MS, Saso L, Cailleau J, Verhoeven G, Bardin CW,
Cheng CY. Regulation of Sertoli cell alpha 2-macroglobulin and clusterin (SGP-2)
secretion by peritubular myoid cells. Biol Reprod. 1993 Jan;48(1):180-7. PubMed
PMID: 7678201.

193: Saso L, Silvestrini B, Zwain I, Guglielmotti A, Luparini MR, Cioli V, Cheng
CY. Abnormal glycosylation of hemopexin in arthritic rats can be blocked by
bindarit. J Rheumatol. 1992 Dec;19(12):1859-67. PubMed PMID: 1284132.

194: Schlegel PN, Matthews GJ, Cichon Z, Aulitzky WK, Cheng CY, Chen CL, Saso L,
Goldstein M, Jänne OA, Bardin CW, et al. Clusterin production in the obstructed
rabbit kidney: correlations with loss of renal function. J Am Soc Nephrol. 1992
Nov;3(5):1163-71. PubMed PMID: 1482755.

195: Silvestrini B, Guglielmotti A, Saso L, Milanese C, Melanitou E, Grima J,
Cheng CY. Development of an enzyme-linked immunosorbent assay with a monoclonal
antibody prepared against alpha 1-antitrypsin for diagnostic screening of
inflammatory disorders. Clin Chem. 1990 Feb;36(2):277-82. PubMed PMID: 1689223.

196: Silvestrini B, Guglielmotti A, Saso L, Cheng CY. Changes in concanavalin
A-reactive proteins in inflammatory disorders. Clin Chem. 1989
Nov;35(11):2207-11. PubMed PMID: 2479495.