Catalogo dei Corsi di studio

Luca Romanelli

Esperienza professionale
2001-presente: Ricercatore, Università di Roma Sapienza
2006 presente: Clinical Pharmacology Expert EMA, European Medicine Agency
2005 -2013: Consulente regolatorio, AMSA srl IBSA corporation
1999 2001: Collaboratore tecnico-scientifico, Ministero della Sanità, Dipartimento per la Valutazione dei Medicinali e la Farmacovigilanza

Dal 2001 docente di discipline farmacologiche e tossicologiche (SSD BIO14) per corsi di laurea, laurea magistrale, specializzazione, master dell'Università Sapienza.

Istruzione e formazione
1999-2002 Specializzazione in Farmacologia, indirizzo tossicologico
1989-1992 Dottorato di Ricerca in Scienze Farmaceutiche
1981-1988 Laurea in Chimica e Tecnologia Farmaceutiche
1974-1979 Maturità classica

Pubblicazioni selezionate
VALERI P., ROMANELLI L., DE PAOLIS L. and MARTINELLI B. Ocular distribution of aspirin and salicylate following systemic administration of aspirin. J. Pharm. Pharmacol., 40: 823-824, 1988
ROMANELLI L., VALERI P., MORRONE L.A. and PIMPINELLA G. Ocular disposition of acetaminophen and its metabolites following intravenous administration in rabbits. J. Ocular Pharmacol., 7: 339-350, 1991
VALERI P., MORRONE L.A. and ROMANELLI L. Manifestations of acute opiate withdrawal contracture in rabbit jejunum after u-,k- and d-receptor agonist exposure. Br. J. Pharmacol., 106: 39-44, 1992
VALERI P., MORRONE L.A., ROMANELLI L. and AMICO M.C. Effect of non-steroidal anti-inflammatory drugs on withdrawal responses in guinea-pig ileum after a brief exposure to morphine. J. Pharmacol. Exp. Ther., 264: 1028-1032, 1993.
ROMANELLI L., VALERI P., MORRONE L.A., PIMPINELLA G., GRAZIANI G. and TITA B. Ocular absorption and distribution of bendazac after topical administration to rabbits with different vehicles. Life Sci., 54: 877-885, 1994
VALERI P., ROMANELLI L., MORRONE L.A., AMICO M.C. and MATTIOLI F. Mu and Kappa opioid system interactions in the expression of acute opioid dependence in isolated guinea-pig ileum. Neuropharmacology, 35: 377-84, 1996
PESSOTTO, P., LIBERATI, R., PETRELLA, O., ROMANELLI, L. and HULSMANN, W.C. In experimental diabetes the fall of lens carnitine levels is an initial important and selective event. Exp. Eye Res., 64: 185-201, 1997
ROMANELLI, L., AMICO, M.C., MATTIOLI, F., MORRONE, L.A. and VALERI, P. Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum. Br. J. Pharmacol., 127: 909-918, 1999
ROMANELLI L., AMICO M.C., MATTIOLI F., MEMOLI A., SAVINI G., MULLER A. Effects of insulin-induced hypoglycemia and normoglycemic hyperinsulinemia on the retinal uptake and ocular metabolism of glucose in rabbits. Metabolism Clinical and Experimental 53: 1274-1284, 2004
ROMANELLI L., PALMERY M., TUCCI P., AMICO M.C., MORRONE L.A., VALERI P. Involvement of the cannabinoid CB1 receptor in the opioid inhibition of the response to CCK-8 and acute withdrawal response. Neurotoxicology, 26:819-827, 2005
MARINI P, ROMANELLI L, VALERI D, TUCCI P, VALERI P, PALMERY M. Acute withdrawal induced by adenosine A1-receptor activation in isolated guinea-pig ileum: role of opioid receptors and effect of cholecystokinin. J Pharm. Pharmacol. 62: 622-32, 2010
MARINI P, ROMANELLI L, VALERI D, CASCIO MG, TUCCI P, VALERI P, PALMERY M. The NOP receptor involvement in both withdrawal- and CCK-8-induced contracture response of guinea-pig isolated ileum after acute activation of -opioid receptor. Peptides 38(2):418-26, 2012
POMPONIO G, SAVARY C, PARMENTIER C, BOIS F, GUILLOUZO A, ROMANELLI L, RICHERT L, DI CONSIGLIO E, TESTAI E. In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments. Toxicol In Vitro 30(1 Pt A):36-51, 2015
POMPONIO G, ZURICH MG, SCHULTZ L, WEISS DG, ROMANELLI L, GRAMOWSKI-VOSS A, DI CONSIGLIO E, TESTAI E. Amiodarone biokinetics, the formation of its major oxidative metabolite and neurotoxicity after acute and repeated exposure of brain cell cultures. Toxicol In Vitro 30(1 Pt A):192-202, 2015
ROMANELLI L, MHILLAJ E, CUOMO V. The importance of reporting unexpected drug failure. J Pharmacovigil 4: 1, 2016
ROMANELLI L, EVANDRI MG. Permitted daily dose exposure for diisopropyl ether as a residual solvent in pharmaceuticals. Toxicol. Res., 34(2):111-125, 2018