Catalogo dei Corsi di studio

Dr. Marco Cippitelli.

CURRICULUM VITAE ET STUDIORUM

Education and professional experience
1990. Graduated in Biological Science (summa cum laude), University of Rome "La Sapienza".
1992-1995. Visiting Scientist at the "Biological Carcinogenesis and Development Program, Molecular Immunology Section" (Laboratory of Experimental Immunology) National Cancer Institute (NCI) Frederick, Maryland, USA.
1996. PhD, University of Rome "La Sapienza".
1996-2000. Research Scientist at the Laboratory of Immunology (Dept. Experimental Medicine and Pathology) and Laboratory of Pathophysiology, CRS, Regina Elena, Rome.
2000-2007. Research Associate - General Pathology (Med-04), Dept. of Experimental Medicine
and Pathology, University of Rome "La Sapienza".
2007-2021. Associate Professor - General Pathology (Med-04), Dept. of Molecular Medicine, University of Rome "La Sapienza".
2022. Full Professor - General Pathology (Med-04), Dept. of Molecular Medicine, University of Rome "La Sapienza".
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Dr. Cippitelli is member of the Società Italiana di Immunologia, Immunologia Clinica ed Allergologia (S.I.I.C.A.) and referee of different international journals such as: Journal of Immunology, European Journal of Immunology, Immunology letters, Haematologica, Molecular Pharmacology, International Journal of Medical Sciences, Oncotarget, Annals of Hematology, Carcinogenesis, Molecular Cancer, Cancers, Cells, Cancer Immunology and Immunotherapy, Journal of Hematology and Oncology, Frontiers in Immunology, Faseb J, Plos One.

- Project reviewer by national (MIUR / PRIN) and international (Irish Research Council) agencies.

- Lead Investigator of research grants from Ministry of Education, University and Research (MIUR) and Ministry of Health (Ministero della Salute), Università degli Studi di Roma La Sapienza - Italy, CNR.

- Lecturer in Immunology and Immunopathology, General Pathology (Faculty of Pharmacy and Medicine University of Rome - La Sapienza, Italy).

- Supervisor of Graduate Students, PhD Students and Postdoctoral Fellows.

Dr. Cippitelli research activity has been mainly conducted in the field of transcriptional regulation and tumor immunology, aimed at understanding the mechanisms underlying the regulation of genes involved in NK cell antitumor effector functions.

Main areas of interest over the years:

1992/95: - Transcriptional events that regulate IFN-gamma, IL-2 and IL-4 genes in activated T cells. Analysis of the role of AP1/CREB-ATF, NF-AT, NF-kB transcription factors involved in these events. These studies have given important contributions to understand the intracellular pathways that regulate these genes in T cells.
1996/98: - Molecular mechanisms that modulate the transcription of the IFN-gamma and IL-12 genes, activated by the nuclear receptor vitamin D3 in T cells and monocytes/dendritic cells.
- Signaling pathways involved in the activation of the IFN-gamma gene, mediated by integrin receptors, in NK cells.
- The anti-apoptotic protein Bcl-2 as a molecule able to regulate NF-kB transcriptional activity and MMP-9 metallo-proteinase gene expression, in human breast carcinoma cells.

2000/2003: - Study of the molecular mechanisms that modulate the transcription and function of the FasL gene by different nuclear receptors and specific ligands in activated T cells: modulation mediated by Calcitriol (Vitamin D3)/VDR, and by activators of the PPAR-gamma.

2003/2005: - Molecular mechanisms regulated by hyperthermia, that enhance the transcription of the FasL gene in activated T cells.

2005/2007: - Study of the molecular mechanisms that modulate the transcription and function of the Rank-L and TRAIL genes by nuclear receptors and specific ligands in activated T cells: modulation mediated by activators of the PPAR-gamma.

2007/Present: Molecular mechanisms that regulate the transcription, expression and function of NK cell-activating ligands by different chemotherapeutics, in Multiple Myeloma cells.

- Heat shock protein-90 inhibitors and expression of MHC class I-related chain A and B ligands on multiple myeloma cells: upregulation of NK cell degranulation against MM.
- Immunoregulatory activity of IMiDs in Multiple Myeloma: mechanisms involved and focus on MEIS2/CRBN.
- Liver X Receptors as regulators of cholesterol metabolism and NK cell-activating ligands in Multiple Myeloma.
- Bromodomain and extra-terminal (BET) inhibitors and immunomodulation in Multiple Myeloma: focus on the role of cMYC-IRF4-miR-125b interplay.
- Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition.

2019/Present: - Study of the role mediated by the ribonuclease RNASET2 in the regulation of the immune innate response-mediated mechanisms against multiple myeloma.

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As project leader, has obtained research grants from different sources. Within these (selected):

2001/2003 - Ministry of Health Project. Identificazione di molecole coinvolte nello stress ossidativo quali bersagli per la terapia antitumorale . Coordinator: Dr. Gabriella Zupi, Istituto Regina Elena, CRS, Roma.
2001/2002 - CNR, Regolazione trascrizionale del ciclo cellulare: ruolo di Rb e dei segnali di co-regolazione . Program CNR-Agenzia 2000 , Coordinator: Prof. Alberto Gulino, University of Rome La Sapienza , Roma.
2003/2005 - Ministry of Health Project. Alterazioni fenotipiche e molecolari associate alla risposta a terapie ormonali in pazienti affette da carcinoma mammario . Coordinator: Dr.ssa Marcella Mottolese, Istituto Regina Elena, CRS, Roma.
2006/2008 - Ministry of the University, PRIN, Analysis of GITR gene expression in T lymphocytes and specific pharmacological modulation. Coordinator Prof. Carlo Riccardi, Univ. of Perugia, Italy.
2008/2010 - Ministry of the University, PRIN, Microenvironment and responses to therapy in Multiple Myeloma: alteration of pathologic osteoclastogenic potential. Coordinator Prof. Antonio Sica, Univ. of Piemonte Orintale "Amedeo Avogadro"-Vercelli, Italy.
2010/2013 - Ministry of the University, PRIN, "Multiple Myeloma Immune Microenvironment As Target To Understand And Overcome Mechanisms Of Clinical Relapse And Resistance". Coordinator Prof. Angelo Vacca, Univ. of BARI "ALDO MORO", Italy.
2017 - Ministry of the University, PRIN, "RNASET2 as new player in the modulation of the innate immune system in cancer and autoimmunity: potential diagnostic and therapeutic implications . Coordinator Prof. Douglas Noonan, Univ. of Insubria , Italy.
2019/2021 - Progetti di Ricerca Grandi Ateneo, Univ. La Sapienza, Rome, Italy. Harnessing NK cells by genetic and epigenetic rerouting to overcome Multiple Myeloma immune evasion .
2022 Progetti di Ricerca Medi Ateneo, Univ. La Sapienza, Rome, Italy. Inhibition of Neddylation as a strategy to boost NK cell responses against Multiple Myeloma .
2022 - Ministry of the University, PRIN, "Strategies to boost NK cell responses against cancer by regulation of NK cell-activating ligands, death receptors and effector activity . Coordinator Prof. Marco Cippitelli, Univ. La Sapienza, Rome, Italy.

Main Bibliometric Indicators:
H index: 36 (Scopus)
Citations: 4431 (Scopus)
ORCID ID: orcid.org/0000-0002-9620-538X
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Laboratory setting:
Dr. Cippitelli works at the Molecular Immunology and Immunopathology, Department of Molecular Medicine, University of Rome - La Sapienza.
The laboratory is fully equipped for cellular and molecular biology/immunology studies and shares with other labs in the Department high-tech equipments and core facilities (BD FACSCanto II and LSRF-Fortessa for cytofluorimetric analysis, Bio-Plex MAGIX multiplex reader, Incucyte® System for Live-Cell Imaging and Analysis, cell culture rooms, P3 room for retro/lentivirus handling, Xenogen III IVIS Lumina III and animal facility). We have also access to the facilities of the IIT Centre of Nanomedicine, https://www.iit.it/it/centers/clns-sapienza (located in the same building of our laboratory), equipped with FACSAria II cell sorter and confocal microscope (Olympus FV1200 laser scanning).
The DMM ranked among the Departments of Excellence, as defined by the Italian Ministry of Instruction, University and Research (MIUR). http://dmm.uniroma1.it/en.