Docente
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BERNARDINI GIOVANNI
(programma)
- Introduction to cells, organs and function of immune system
- Role of innate immunity in generating specific immune responses.
- The antigen-presenting cells to T lymphocytes (dendritic cells and macrophages).
- T cell maturation and activation
- B cell maturation and activation
- Epigenetic modifications in immune cells. Mechanisms and analysis. Role in maturation and differentiation to effector cells.
- Effector cell-mediated mechanisms. The role of helper T cells in determining the nature of the immune response.
- The activation of macrophages: phagocytosis and cytolysis
- Humoral immunity effector mechanisms.
- Molecules involved in immunity to infection and mechanisms of viral immune evasion
- Molecules involved in immunity to tumors and mechanisms of tumor immune evasion
- Molecular oncology in the diagnosis and development of targeted therapies
Learning results
This course is aimed at providing an overview of the most important cellular and molecular mechanisms involved in the regulation of the immune response in order to comprehend their specific role in the resistance against pathologies. More in detail, students will learn:
Student will acquire fundamental knowledge on
- how immune cells function and interplay to participate to immune responses
- how immune system protects us from pathogens and how mechanisms that inhibit immune responses lead to disease state.
- how interpretation of transcriptomic and proteomic data helps to elucidate mechanisms of development of the immune response.
At the end of the course, students will be able to explain how immune system works and to understand and explain data obtained from multiparametric analysis of immune cell function at transcriptional and post-transcriptional levels. The use of bioinformatics tools to clarify the molecular processes underlying pathologies and their use in diagnosis and treatment of diseases will be discussed.
A.K. Abbas, A.H. Lichtman, S. Pillai.
BASIC IMMUNOLOGY. Function and disorders of the Immune System
5TH edition, Masson.
C.A. Janeway, K. Murphy, P. Travers, M. Walport.
IMMUNOBIOLOGY, Piccin.
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