1. Introduction to Medicinal Chemistry 1A. History 1B. Drugs and Drug Targets 1C. Drug Discovery Screening Techniques 2. Drug Targets 2A. Proteins 2B. Lipids 2C. Sugars 3. Farmacodinamics 3A. Drug-Target interactions 3B. Drug Mechanisms of Action with Receptors and Enzymes 4. Farmacokinetics 4A. ADME Properties 4B. Metabolism 5. Drug Discovery 5A. Hit and Lead 5B. Structure Activity Relationships 6. Drug Design 6A. The computer in Drug Design 6B. Introduction toLigand-Based Drug Design 6C. QSAR 6D. Introduction to 3-D QSAR 6E. Introduction to Structure-Based Drug Design 7. Practical Exercizes on General Med Chem 7A. How to draw molecules in 2-D and 3-D 7B. Analysis of three-dimensional Drug/Target interactions 7C. Ligand-Based Methods: basics approaches on how to build a QSAR model 7D. Ligand-Based Methods: basics approaches on how to build a 3-D QSAR model 7E. Structure-Based Methods: basics approaches on how to perform molecular docking of a small molecule in a macromolecule

- Foye. Principles of medicinal chemistry. - Patrick. An Introduction to Medicinal Chemistry. - Burger. Drug Discovery. - Wermuth. The Practice of Medicinal Chemistry. - Comprehensive Medicinal Chemistry II. - Lectures available from e-learning web platform. (https://elearning.uniroma1.it/course/view.php?id=4523)